HOOK3 and VPS16

Number of citations: 36 (PubMedID 18799622)
Data Source: HPRD (in vivo)

		HOOK3	VPS16
Name		hook microtubule tethering protein 3	VPS16 core subunit of CORVET and HOPS complexes
Structure
GO Annotations	Cellular Component	Pericentriolar Material Cytoplasm Golgi Apparatus Cis-Golgi Network Centrosome Cytoskeleton Microtubule HOPS Complex Centriolar Satellite FHF Complex	Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Endosome Membrane Membrane Clathrin-coated Vesicle Axon HOPS Complex Cytoplasmic Vesicle Late Endosome Membrane CORVET Complex Neuronal Cell Body Recycling Endosome Presynapse Vesicle Tethering Complex
	Molecular Function	Protein Binding Microtubule Binding Dynactin Binding Identical Protein Binding Dynein Light Chain Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Actin Binding Protein Binding Actin Filament Binding
	Biological Process	Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Interkinetic Nuclear Migration Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Microtubule Anchoring At Centrosome Early Endosome To Late Endosome Transport Negative Regulation Of Neurogenesis Golgi Localization Protein Localization To Centrosome Neuronal Stem Cell Population Maintenance Protein Localization To Perinuclear Region Of Cytoplasm	Intracellular Protein Transport Autophagy Vacuole Organization Endosome To Lysosome Transport Protein Transport Endosomal Transport Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Vacuole Fusion, Non-autophagic Autophagosome Maturation
Pathways		None	SARS-CoV-2 modulates autophagy
GWAS		Zinc levels ( 26025379 )	Lymphocyte percentage of white cells ( 32888494 ) Metabolite levels ( 23823483 )
Interacting Genes		11 interacting genes: AKTIP CTIF EIF4ENIF1 HOOK1 HOOK2 KRT13 MAPT MEOX2 PNMA5 VPS16 VPS41	18 interacting genes: AKTIP EXOC8 FBXO7 GNG13 HOOK1 HOOK2 HOOK3 MON1B RAB7A RILP STX1A STX7 UBC UVRAG VPS11 VPS18 VPS33A ZNF417
Entrez ID		84376	64601
HPRD ID		09699	12259
Ensembl ID		ENSG00000168172	ENSG00000215305
Uniprot IDs		Q86VS8	Q9H269
PDB IDs		5J8E 6B9H 8QAT 9KNS 9KO8	4BX9
GO Terms Enriched among Interactors		HOPS Complex Endosome To Lysosome Transport FHF Complex Lysosomal Transport Protein Localization To Perinuclear Region Of Cytoplasm Vacuolar Transport Early Endosome To Late Endosome Transport Vesicle Organization Vacuole Organization Intracellular Transport Cytoplasmic Microtubule Organization Lysosome Organization Microtubule Binding Endosome Organization Endosomal Transport Cellular Localization Establishment Of Localization In Cell Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Protein Transport Organelle Organization Establishment Of Protein Localization Dynein Light Intermediate Chain Binding Supramolecular Fiber Organization Cytoskeleton-dependent Intracellular Transport Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Microtubule Cytoskeleton Intracellular Protein Localization Vesicle-mediated Transport Neurofibrillary Tangle Assembly Clathrin-coated Vesicle Lysosomal HOPS Complex Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Vacuole Fusion, Non-autophagic Indoleamine 2,3-dioxygenase Activity Cytoplasmic Ribonucleoprotein Granule Microtubule Tryptophan 2,3-dioxygenase Activity Vesicle Fusion Actin Binding Organelle Membrane Fusion PML Body Vesicle Tethering Complex Regulation Of Translation Regulation Of Protein Metabolic Process Main Axon Negative Regulation Of Mitochondrial Fission	Endosome To Lysosome Transport HOPS Complex Vesicle Organization Vacuolar Transport Lysosomal Transport Endosome Organization Early Endosome To Late Endosome Transport Vesicle-mediated Transport Establishment Of Protein Localization Protein Transport Late Endosome FHF Complex Protein Localization To Perinuclear Region Of Cytoplasm Cellular Localization Intracellular Transport Organelle Localization Membrane Docking Vacuole Organization Vesicle Fusion Organelle Membrane Fusion Intracellular Protein Localization Establishment Of Localization In Cell Organelle Fusion Vesicle Docking Lysosome Organization Membrane Fusion Organelle Localization By Membrane Tethering Dynein Light Intermediate Chain Binding CORVET Complex Organelle Organization Vesicle Docking Involved In Exocytosis Membrane Organization Endosomal Transport Lysosome Autophagy Late Endosome Membrane Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Intracellular Protein Transport Autophagosome Lysosomal Membrane Endosome Endosome Membrane Cytoplasmic Vesicle Early Endosome Syntaxin Binding Chloride Channel Inhibitor Activity SNARE Binding Cytoplasmic Microtubule Organization Protein Modification By Small Protein Conjugation