TEKT1 and PRKAG1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TEKT1	PRKAG1
Name		tektin 1	protein kinase AMP-activated non-catalytic subunit gamma 1
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Microtubule Axonemal Microtubule Cilium Microtubule Cytoskeleton Motile Cilium Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex
	Molecular Function	Protein Binding	Nucleotide Binding AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding CAMP-dependent Protein Kinase Regulator Activity AMP Binding Protein Kinase Regulator Activity Protein Kinase Binding ADP Binding Protein-containing Complex Binding
	Biological Process	Flagellated Sperm Motility Cilium Assembly Cilium Movement Involved In Cell Motility	Regulation Of Glycolytic Process Protein Phosphorylation Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Signal Transduction Spermatogenesis Cellular Response To Nutrient Levels Cellular Response To Glucose Starvation Regulation Of Carbon Utilization Positive Regulation Of Gluconeogenesis Import Into Nucleus Regulation Of Cell Cycle
Pathways		None	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs		None	Adenosine phosphate Acetylsalicylic acid Fostamatinib
GWAS		Mild influenza (H1N1) infection ( 26379185 )	Adult body size ( 32376654 ) Bipolar disorder ( 31043756 ) Body mass index ( 29273807 ) HDL cholesterol ( 30275531 ) Pulse pressure ( 27618447 ) Red cell distribution width ( 32888494 ) Systolic blood pressure ( 27618447 30578418 )
Novel Interactors		None recorded	2 novel interactors: SHMT2 TUBA1C
Interacting Genes		26 interacting genes: BYSL C1orf74 CCHCR1 CFAP206 CHD2 EFHC1 HGS HNRNPH2 KLHL38 KRT75 L3MBTL2 LGALS14 MID2 NCAPD3 NME7 NTAQ1 NUP54 PRKAG1 RUNX1T1 SDCBP TEKT4 TSGA10IP UBASH3A UNC45A USHBP1 VCL	31 interacting genes: ACACA AP1S3 C1orf94 CBS CRBN EIF3G KCNN4 KEAP1 KLHL20 KRTAP1-1 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP4-12 KRTAP4-2 KRTAP9-2 KRTAP9-8 MEOX1 MEOX2 PAICS PAX6 PLEKHF2 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG2 PRKDC TEKT1 TNFAIP1
Entrez ID		83659	5571
HPRD ID		10611	04118
Ensembl ID		ENSG00000167858	ENSG00000181929
Uniprot IDs		Q969V4	F8VYY9 P54619
PDB IDs		7UNG 8J07	2UV4 2UV5 2UV6 2UV7 4CFE 4CFF 4RER 4REW 4ZHX 5EZV 5ISO 6B1U 6B2E 6C9F 6C9G 6C9H 6C9J 7JHG 7JHH 7JIJ 7M74 7MYJ 8BIK
GO Terms Enriched among Interactors		Histone H4K20me1 Reader Activity Axonemal A Tubule Inner Sheath Axonemal Microtubule Cilium Movement Positive Regulation Of Exosomal Secretion Motile Cilium Regulation Of Exosomal Secretion	Keratin Filament Nucleotide-activated Protein Kinase Complex Intermediate Filament AMP-activated Protein Kinase Activity Carboxylic Acid Biosynthetic Process Cytosol Fatty Acid Biosynthetic Process Small Molecule Biosynthetic Process Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Cellular Response To Prostaglandin E Stimulus Cellular Response To Prostaglandin Stimulus Fatty Acid Metabolic Process Response To Prostaglandin E Protein Localization To Lipid Droplet Monocarboxylic Acid Metabolic Process Somite Specification Carboxylic Acid Metabolic Process Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process Organic Acid Metabolic Process Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Sterol Biosynthetic Process Cellular Response To Glucose Starvation Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Nutrient Levels Regulation Of Glycolytic Process Phosphatidylethanolamine Biosynthetic Process Cul3-RING Ubiquitin Ligase Complex Regulation Of Protein Deacetylation Regulation Of Stress Granule Assembly Protein Homotetramerization HMG Box Domain Binding Regulation Of Carbohydrate Catabolic Process Response To Nutrient Levels L-serine Metabolic Process Hair Cycle Segment Specification Somite Development Regulation Of ATP Metabolic Process Lipid Biosynthetic Process Fatty Acid Homeostasis Hepatocyte Apoptotic Process Protein Homooligomerization Regulation Of Purine Nucleotide Metabolic Process Steroid Biosynthetic Process Protein Tetramerization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Phosphatidylcholine Biosynthetic Process