DYNLRB1 and MPHOSPH6

Number of citations: 47 (PubMedID 15231747)
Data Source: HPRD (two hybrid)

		DYNLRB1	MPHOSPH6
Name		dynein light chain roadblock-type 1	M-phase phosphoprotein 6
Structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytoskeleton Cytoplasmic Dynein Complex Microtubule Cilium Membrane Dynein Complex Ciliary Tip	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Microtubule Motor Activity Protein Binding Identical Protein Binding Dynein Intermediate Chain Binding	RNA Binding Protein Binding
	Biological Process	Microtubule-based Movement Visual Behavior Positive Regulation Of Intracellular Transport	Maturation Of 5.8S RRNA RRNA Processing
Pathways		Intraflagellar transport	Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
GWAS		Alanine aminotransferase levels ( 33547301 ) Bipolar disorder ( 31043756 ) Colorectal cancer or advanced adenoma ( 30510241 ) Fish- and plant-related diet ( 32066663 ) Oily fish consumption ( 32066663 ) Pork consumption ( 32066663 ) Pulse pressure ( 30224653 )	Leukocyte telomere length ( 31171785 32109421 ) Lung adenocarcinoma ( 28604730 ) Nevus count or cutaneous melanoma ( 32341527 ) Obesity-related traits ( 23251661 ) Parkinson's disease motor subtype (tremor dominant vs postural instability/gait difficulty) ( 33987465 ) Seasonality and depression ( 30217971 )
Interacting Genes		10 interacting genes: CEBPA CPEB1 CRCP DYNC1I1 DYNC1I2 HSPH1 MAGEA2 MAGEA2B MPHOSPH6 PALS2	28 interacting genes: AATF APLP1 ARHGAP18 CRYAA DNM2 DYNLRB1 EIF3G ERG28 EXOSC10 EXOSC3 EXOSC5 FTL GDF9 HSPB1 KNSTRN LRIF1 MTREX NUPR1 PARN RBM48 RPS20 SMARCA4 SNX9 THOP1 TLE1 TP53 UNC119 ZHX1
Entrez ID		83658	10200
HPRD ID		06203	16111
Ensembl ID		ENSG00000125971	ENSG00000135698
Uniprot IDs		B4DFR2 Q9NP97	H3BNT4 Q99547
PDB IDs		1Z09 2B95 2E8J 2HZ5 6F1T 6F1Z 6F38 6F3A 6RLB 6SC2 7Z8F 8J07 8PR1 8PTK 8RGG 8RGH	6D6Q 6D6R 6H25
GO Terms Enriched among Interactors		Negative Regulation Of Protein Acetylation Dynein Light Chain Binding Negative Regulation Of Protein Sumoylation Dynein Heavy Chain Binding Positive Regulation Of Ubiquitin-protein Transferase Activity Histone Deacetylase Binding Cytoplasmic Dynein Complex Regulation Of Protein Sumoylation Regulation Of Ubiquitin-protein Transferase Activity DNA-binding Transcription Factor Binding Dynein Complex RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Microtubule Motor Activity Cellular Senescence DNA Polymerase III Complex Microtubule Response To Vitamin B2 C/EBP Complex RNA Polymerase Complex Negative Regulation Of Post-translational Protein Modification Signal Transduction By P53 Class Mediator CHOP-C/EBP Complex Positive Regulation Of Protein Ubiquitination PML Body White Fat Cell Proliferation Calcitonin Gene-related Peptide Receptor Activity Positive Regulation Of Post-translational Protein Modification Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Positive Regulation Of MHC Class I Biosynthetic Process Response To Phenylpropanoid Negative Regulation Of Protein Metabolic Process Regulation Of MHC Class I Biosynthetic Process Transcription Initiation At RNA Polymerase III Promoter	Poly(A)-dependent SnoRNA 3'-end Processing Sno(s)RNA Metabolic Process Exosome (RNase Complex) Nuclear Exosome (RNase Complex) 3'-5'-RNA Exonuclease Activity Nucleolar Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity SnRNA Metabolic Process MRNA Metabolic Process RNA 3'-end Processing RNA Catabolic Process RNA Binding Nuclear-transcribed MRNA Catabolic Process SnRNA Catabolic Process Nuclear RNA Surveillance CUT Catabolic Process RNA Surveillance Regulation Of Female Gonad Development Regulation Of Telomere Maintenance Via Telomerase RRNA Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process MRNA Catabolic Process U4 SnRNA 3'-end Processing Identical Protein Binding Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Macromolecule Biosynthetic Process Nucleolus RRNA 3'-end Processing Euchromatin TRNA Decay Nuclear MRNA Surveillance Nucleoplasm Negative Regulation Of Biosynthetic Process Regulation Of Telomerase RNA Localization To Cajal Body MDM2/MDM4 Family Protein Binding DNA Deamination Negative Regulation Of Metabolic Process Nucleobase-containing Compound Catabolic Process Response To Heat Regulation Of DNA Biosynthetic Process RRNA Processing Negative Regulation Of Gene Expression Maturation Of 5.8S RRNA Regulation Of Cell Growth Negative Regulation Of Macromolecule Metabolic Process Regulation Of Fibroblast Apoptotic Process