C11orf68 and SH3GL3

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		C11orf68	SH3GL3
Name		chromosome 11 open reading frame 68	SH3 domain containing GRB2 like 3, endophilin A3
Structure
GO Annotations	Cellular Component	None	Acrosomal Vesicle Cytoplasm Endosome Early Endosome Membrane Early Endosome Membrane Presynapse Postsynaptic Endosome Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	RNA Binding Protein Binding	Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	None	Endocytosis Signal Transduction Central Nervous System Development Positive Regulation Of Neuron Differentiation Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Clathrin-dependent Endocytosis
Pathways		None	EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell NGF-stimulated transcription
GWAS		Acne (severe) ( 24927181 ) Asthma ( 31959851 )	A body shape index ( 34021172 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) ( 30920136 ) FEV1 ( 30804560 ) Gynecologic disease (multivariate analysis) ( 31488892 ) Height ( 18391951 28552196 25282103 20397748 18391950 ) Hip circumference adjusted for BMI ( 28552196 34021172 ) Hip index ( 34021172 ) Lung function (FEV1/FVC) ( 28166213 30804560 ) Proteinuria and chronic kidney disease ( 26420894 ) Smoking initiation ( 33082346 ) Spine bone size ( 31053729 ) Waist circumference adjusted for body mass index ( 34021172 ) Working memory ( 31598132 )
Interacting Genes		14 interacting genes: CSDE1 EIF4H KCNE3 KLF15 MEOX2 MTCL1 NONO PHETA1 REL SDCBP SH3GL3 TRAPPC2L ZNF341 ZNF512B	52 interacting genes: ADRB1 ANTKMT ARHGDIA ARHGEF6 ATXN2 C11orf68 C4orf17 CALCOCO1 CBLC CD101 CRIP1 DNAJC5 DNM1 DPPA4 DPYSL4 EGFL6 EGFR EMD FASLG FBXO32 GABBR2 GOLT1B HTT LRRK2 NDUFB9 PDCD6IP PIAS4 PTPRO QTRT1 RABAC1 RBM48 RER1 RNF8 RPL35A SEPTIN8 SH3D19 SH3GL1 SH3GL2 SH3KBP1 SHANK3 SHC3 SNRPN SNX24 SYNJ1 TERF1 TLE5 TMEM120B TNNT1 TOE1 VIM WASL WDR33
Entrez ID		83638	6457
HPRD ID		12553	04528
Ensembl ID		ENSG00000175573	ENSG00000140600
Uniprot IDs		Q9H3H3	Q99963
PDB IDs		1ZTP 2Q4K	2EW3 2Z0V
GO Terms Enriched among Interactors		None	Presynapse Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of CAMKK-AMPK Signaling Cascade Presynaptic Cytosol Central Nervous System Development Cytoplasmic Side Of Mitochondrial Outer Membrane Cytoplasm Negative Regulation Of ERBB Signaling Pathway Cytoplasmic Vesicle Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Vocal Learning Observational Learning Synapse