H2BC21 and RNF20

Number of citations: 66 (PubMedID 24837678)
Data Source: BioGRID (enzymatic study)

		H2BC21	RNF20
Name		H2B clustered histone 21	ring finger protein 20
Structure
GO Annotations	Cellular Component	Nucleosome Extracellular Space Nucleus Nucleoplasm Chromosome Cytosol Extracellular Exosome	Ubiquitin Ligase Complex Nucleus Nucleoplasm Nucleolus HULC Complex
	Molecular Function	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	P53 Binding Chromatin Binding Transcription Coactivator Activity MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Histone H2B C-terminal K Residue Ubiquitin Ligase Activity
	Biological Process	Innate Immune Response In Mucosa Nucleosome Assembly Antibacterial Humoral Response Defense Response To Bacterium Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Protein Polyubiquitination Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Protein Ubiquitination Negative Regulation Of Cell Migration Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription	E3 ubiquitin ligases ubiquitinate target proteins RHOBTB1 GTPase cycle
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		73 interacting genes: AIRE AKT1 ANP32A AP2M1 ARID1B ATF2 ATXN7L3 BRD7 CDK9 CREBBP DNMT3L DYRK2 EP300 GADD45A GATAD2A GATAD2B GZMA HDAC2 HIPK2 HIRA HIRIP3 HSPD1 IL33 IL7R KAT2A KAT2B KPNA1 LALBA LOX MAP4K4 MDM2 MSL1 MSL2 NAP1L4 NCL NEIL3 NPM1 PARP10 PARP9 PBRM1 PELP1 PRMT6 PTMA RAG1 RCC1 RNF168 RNF20 RNF8 RPS6KA5 SAP30 SART3 SIRT7 SMU1 SPANXN2 STK38 STK4 TAF1A TAF1B TBL1X TBL1XR1 TGM2 TNPO1 TRAF6 TSPY1 UBC UBE2A USP12 USP15 USP22 USP46 USP49 USP8 VRK1	41 interacting genes: AIRIM AMOTL2 ATM BAG4 CDC73 DIS3L EEF1D FBH1 FGFR4 H2AC18 H2AC20 H2AC4 H2BC21 H2BC3 H3C14 H4C14 HSF1 HTT ITSN2 KIF11 MSL1 NCBP1 PA2G4 PAF1 PRPF8 RAD51 RB1CC1 RBPMS RPA1 RPA2 SUMO2 TACC3 TRIM14 UBE2A UBE2B UBE2D2 UBE2E1 UBE2L3 USHBP1 XRCC3 ZDHHC17
Entrez ID		8349	56254
HPRD ID		03494	07410
Ensembl ID		ENSG00000184678	ENSG00000155827
Uniprot IDs		Q16778	Q5VTR2
PDB IDs		4NFT 6A7U 6KBB 6M4D 6M4G 6M4H 7BXT 7EA8 7U0G 7U0I 7U0J 8DK5 8EVG 8EVH 8EVI 8EVJ 8H1T 8SPS 8SPU 8SYP 8UQ8 8UQ9 8UQA 8UQB 8UQC 8UQD 8UQE 8YJF	5TRB 8GUI 8GUJ 8IEJ
GO Terms Enriched among Interactors		Chromatin Organization Chromatin Remodeling Histone Binding Nucleoplasm Nucleus Protein Modification Process Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Damage Response Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Cellular Response To Stress Post-translational Protein Modification Regulation Of DNA Metabolic Process Regulation Of DNA Repair Negative Regulation Of Macromolecule Metabolic Process Transferase Activity Nucleic Acid Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Epigenetic Regulation Of Gene Expression Cellular Response To Stress Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Positive Regulation Of Transcription By RNA Polymerase II Transcription Coactivator Activity Regulation Of Signal Transduction By P53 Class Mediator Histone H3K18 Acetyltransferase Activity	Structural Constituent Of Chromatin Chromosome, Telomeric Region Nucleus Nucleosome Ubiquitin Conjugating Enzyme Activity Nucleoplasm Chromosome Chromatin Organization Telomere Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Protein Heterodimerization Activity Chromatin Remodeling DNA Repair Telomere Maintenance Protein Localization To Chromosome PML Body Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process Regulation Of Metabolic Process Ubiquitin-like Protein Transferase Activity Double-strand Break Repair Chromosome Organization DNA Recombination Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Cellular Response To Ionizing Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Cellular Response To Gamma Radiation Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Cell Cycle Process DNA Metabolic Process Protein Polyubiquitination DNA Binding Positive Regulation Of MRNA 3'-end Processing HULC Complex Nuclear Division MRNA 3'-end Processing DNA Damage Response Endodermal Cell Fate Commitment Protein-DNA Complex Assembly Site Of Double-strand Break Regulation Of Macromolecule Metabolic Process Cdc73/Paf1 Complex Protein K11-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of DNA Metabolic Process Post-translational Protein Modification Meiotic Telomere Clustering