CDCA3 and BCL11A

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		CDCA3	BCL11A
Name		cell division cycle associated 3	BCL11 transcription factor A
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Adherens Junction	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Matrix SWI/SNF Complex Paraspeckles Postsynapse
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Regulatory Region Nucleic Acid Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coregulator Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Ubiquitination Cell Division	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Protein Sumoylation Negative Regulation Of Axon Extension Negative Regulation Of Protein Homooligomerization Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Collateral Sprouting Positive Regulation Of Collateral Sprouting Regulation Of Dendrite Development Negative Regulation Of Dendrite Extension Negative Regulation Of Neuron Remodeling Cellular Response To L-glutamate Negative Regulation Of Dendrite Development Negative Regulation Of Branching Morphogenesis Of A Nerve
Pathways		None	ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
GWAS		No GWAS studies recorded	Acne (severe) ( 30542056 24927181 ) Adult body size ( 32376654 ) Age at first sexual intercourse ( 34211149 ) Attention deficit hyperactivity disorder ( 22012869 ) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027 ) Beta thalassemia/hemoglobin E disease ( 20183929 ) Body size at age 10 ( 32376654 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Childhood absence epilepsy ( 30531953 ) Chronotype ( 30696823 ) Cognitive ability ( 29186694 ) Cognitive ability (MTAG) ( 29186694 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Endometrial cancer ( 30093612 ) Endometrial cancer (endometrioid histology) ( 30093612 ) Epilepsy ( 30531953 ) F-cell distribution ( 17767159 ) F-cell distribution in sickle cell anaemia ( 21326311 ) Face memory ( 31596458 ) Falling risk ( 32999390 ) Fetal hemoglobin levels ( 18245381 20018918 ) Fetal hemoglobin levels in sickle cell anemia ( 25372704 ) General cognitive ability ( 29844566 ) General risk tolerance (MTAG) ( 30643258 ) Generalized epilepsy ( 30531953 ) Heart rate response to exercise ( 29769521 ) Heart rate response to recovery post exercise ( 29769521 ) Heel bone mineral density ( 30598549 ) Hemoglobin A2 levels in sickle cell anemia ( 25042611 ) Hemoglobin levels ( 26366553 ) High fetal hemoglobin in sickle cell disease ( 27022141 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 ) Household income (MTAG) ( 31844048 ) Hypersomnia (HLA-DQB1*06:02 negative) ( 23646285 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Intelligence (MTAG) ( 29326435 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 32888494 19862010 28017375 27863252 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Menarche (age at onset) ( 25231870 ) Methadone dose in opioid dependence ( 28115739 ) Monocyte early outgrowth colony forming units ( 21493818 ) Morning person ( 30696823 ) Number of sexual partners ( 30643258 ) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965 ) Prostate-specific antigen levels ( 30410027 28139693 ) Red blood cell count ( 27863252 32888494 ) Red blood cell traits ( 23222517 ) Red cell distribution width ( 28957414 27863252 32888494 ) Refractive error ( 32231278 ) Resting heart rate ( 27798624 ) Risk-taking tendency (4-domain principal component model) ( 30643258 ) Sickle cell anemia (haemolysis) ( 23406172 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Smoking status (ever vs never smokers) ( 30643258 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Type 1 diabetes ( 34012112 ) Type 2 diabetes ( 28869590 30297969 29358691 30718926 20581827 22885922 32499647 24509480 ) Urinary albumin-to-creatinine ratio in diabetes ( 31511532 ) Walking pace ( 33128006 )
Interacting Genes		10 interacting genes: APP BCL11A CTDSP1 CTDSP2 CUL1 SKP1 TRAF1 TRAF2 UBC WEE1	25 interacting genes: ACTC1 APP BCL6 CDCA3 CDK4 CDK6 EZH2 FXR2 GMCL2 LMO1 MORF4L2 NCK2 NFAM1 NR2E3 NR2F1 NR2F2 NR2F6 PIN1 SIN3A SIRT1 SUZ12 TSC1 UBE2I YME1L1 ZBTB24
Entrez ID		83461	53335
HPRD ID		09670	05949
Ensembl ID		ENSG00000111665	ENSG00000119866
Uniprot IDs		F5GX58 F8WDL1 J3KMY0 Q99618	A0A2R8Y2E8 A0A2U3TZJ5 B4DT16 D9YZV9 D9YZW0 Q9H165
PDB IDs		Not available	5VTB 6KI6 6U9Q 8DTN 8DTU 8THO 8TLO 9B4P 9BV0
GO Terms Enriched among Interactors		Protein Modification Process Ubiquitin Ligase Complex Scaffold Activity Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Thioesterase Binding Protein Metabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Post-translational Protein Modification Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Programmed Cell Death Molecular Function Activator Activity Cell Death Positive Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Tumor Necrosis Factor Receptor Binding Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Mitotic Cell Cycle Nucleoplasm Negative Regulation Of Cell Cycle Phase Transition Protein Ubiquitination Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Epithelial Cell Apoptotic Process Protein Monoubiquitination Protein Polyubiquitination SCF Ubiquitin Ligase Complex SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Tumor Necrosis Factor-mediated Signaling Pathway TORC2 Complex Disassembly Negative Regulation Of Cell Cycle Process Negative Regulation Of Branching Morphogenesis Of A Nerve Negative Regulation Of Neuron Remodeling TORC1 Signaling Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Programmed Cell Death Regulation Of Mitotic Cell Cycle Phase Transition Phosphatase Activity	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Cell Differentiation Regulation Of Macromolecule Metabolic Process Cellular Developmental Process Developmental Process Regulation Of Mitotic Cell Cycle Chromatin Silencing Complex Regulation Of Cell Population Proliferation Nuclear Receptor Activity Facultative Heterochromatin Formation Regulation Of Cell Cycle Regulation Of Primary Metabolic Process ESC/E(Z) Complex Heterochromatin Formation Epigenetic Regulation Of Gene Expression Sequence-specific DNA Binding Negative Regulation Of Gene Expression, Epigenetic RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Cellular Senescence Mononuclear Cell Differentiation Regulation Of Cell Motility Regulation Of Locomotion Leukocyte Activation HLH Domain Binding Leukocyte Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Lymphocyte Differentiation Positive Regulation Of Response To Endoplasmic Reticulum Stress Cell Activation Cellular Response To Stress