KLRC4 and ULBP1

Number of citations: 0 (PubMedID 11777960)
Data Source: HPRD (in vitro, in vivo)

		KLRC4	ULBP1
Name		killer cell lectin like receptor C4	UL16 binding protein 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	External Side Of Plasma Membrane Membrane	Extracellular Space Endoplasmic Reticulum Cytosol Plasma Membrane External Side Of Plasma Membrane Membrane Side Of Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity	Protein Binding Natural Killer Cell Lectin-like Receptor Binding Receptor Ligand Activity
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity	Positive Regulation Of T Cell Mediated Cytotoxicity Immune System Process Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune Response Signal Transduction Natural Killer Cell Activation Natural Killer Cell Mediated Cytotoxicity
Pathways		None	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
GWAS		Behcet's disease ( 23291587 ) Psoriasis ( 28537254 )	Radiation response ( 20923822 )
Interacting Genes		4 interacting genes: MICB RAE1 TYROBP ULBP1	2 interacting genes: KLRC4 RAET1G
Entrez ID		8302	80329
HPRD ID		16008	09297
Ensembl ID		ENSG00000183542	ENSG00000111981
Uniprot IDs		O43908	Q9BZM6
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Natural Killer Cell Lectin-like Receptor Binding Lymphocyte Activation Natural Killer Cell Mediated Immunity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Leukocyte Activation Positive Regulation Of Immune Response Cell Activation Regulation Of Leukocyte Mediated Cytotoxicity Lymphocyte Mediated Immunity Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway Leukocyte Mediated Immunity Negative Regulation Of Defense Response To Virus By Host Regulation Of Immune Response Positive Regulation Of Immune System Process Cell Killing Positive Regulation Of Osteoclast Development Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Macrophage Fusion Microglial Cell Activation Involved In Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response Positive Regulation Of Immune Effector Process Negative Regulation Of Transforming Growth Factor Beta1 Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery T Cell Activation T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Regulation Of Osteoclast Development External Side Of Plasma Membrane Immune Response-activating Signaling Pathway Neutrophil Activation Involved In Immune Response Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Transforming Growth Factor Beta Production Regulation Of Immune System Process Immune Effector Process Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune Response-regulating Signaling Pathway Activation Of Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Negative Regulation Of Defense Response To Virus Negative Regulation Of B Cell Proliferation Immune System Process Gamma-delta T Cell Activation Macrophage Activation Involved In Immune Response Regulation Of Superoxide Anion Generation Cellular Response To Lectin Positive Regulation Of Superoxide Anion Generation Stimulatory C-type Lectin Receptor Signaling Pathway	Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Lymphocyte Mediated Immunity Regulation Of Lymphocyte Mediated Immunity Nuclear Matrix Anchoring At Nuclear Membrane Positive Regulation Of Immune Effector Process Nuclear Matrix Organization Positive Regulation Of Innate Immune Response Cytoskeleton-nuclear Membrane Anchor Activity External Side Of Plasma Membrane Natural Killer Cell Lectin-like Receptor Binding Positive Regulation Of Natural Killer Cell Cytokine Production Meiotic Nuclear Membrane Microtubule Tethering Complex Regulation Of Innate Immune Response Regulation Of Natural Killer Cell Cytokine Production Positive Regulation Of Defense Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Lamin Binding Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Positive Regulation Of Immune Response Maintenance Of Protein Location In Nucleus Antigen Processing And Presentation Of Endogenous Antigen Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Nuclear Outer Membrane Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Defense Response Natural Killer Cell Mediated Cytotoxicity Maintenance Of Protein Localization In Organelle Natural Killer Cell Mediated Immunity Regulation Of T Cell Mediated Cytotoxicity Regulation Of Immune Response Regulation Of Natural Killer Cell Mediated Cytotoxicity Maintenance Of Protein Location In Cell Sarcomere Positive Regulation Of Immune System Process Maintenance Of Protein Location Antigen Processing And Presentation Of Peptide Antigen Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Mediated Immunity Maintenance Of Location In Cell Leukocyte Mediated Cytotoxicity Maintenance Of Location Positive Regulation Of Cytokine Production Involved In Immune Response