KLRC4 and TYROBP

Number of citations: 0 (PubMedID 12426564)
Data Source: HPRD (in vivo)

		KLRC4	TYROBP
Name		killer cell lectin like receptor C4	transmembrane immune signaling adaptor TYROBP
Structure		No pdb structure
GO Annotations	Cellular Component	External Side Of Plasma Membrane Membrane	Plasma Membrane Cell Surface Membrane Secretory Granule Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity	Signaling Receptor Binding Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Molecular Adaptor Activity
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity	Negative Regulation Of Cytokine Production Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway Stimulatory C-type Lectin Receptor Signaling Pathway Natural Killer Cell Mediated Immunity Immune Effector Process Myeloid Leukocyte Activation Macrophage Activation Involved In Immune Response Microglial Cell Activation Involved In Immune Response Neutrophil Activation Involved In Immune Response T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Immune System Process Positive Regulation Of Immune System Process Defense Response Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Gene Expression Actin Cytoskeleton Organization Osteoclast Differentiation Negative Regulation Of B Cell Proliferation Forebrain Development Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Negative Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Macrophage Fusion Intracellular Signal Transduction Apoptotic Cell Clearance Response To Axon Injury Protein Stabilization Regulation Of Biological Quality Semaphorin-plexin Signaling Pathway Amyloid-beta Clearance Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Microglial Cell Mediated Cytotoxicity Cellular Response To Amyloid-beta Positive Regulation Of Protein Localization To Cell Surface Regulation Of Osteoclast Development Positive Regulation Of Osteoclast Development
Pathways		None	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 interactions DAP12 signaling DAP12 signaling Signal regulatory protein family interactions Other semaphorin interactions Neutrophil degranulation
Diseases		None	Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); Nasu-Hakola disease
GWAS		Behcet's disease ( 23291587 ) Psoriasis ( 28537254 )	No GWAS studies recorded
Interacting Genes		4 interacting genes: MICB RAE1 TYROBP ULBP1	15 interacting genes: CD300E CLEC5A KIR3DS1 KLRC3 KLRC4 KLRK1 NCR2 SIGLEC14 SIRPB1 SLC35B4 SYK TMEM86A TREM1 TREM2 ZAP70
Entrez ID		8302	7305
HPRD ID		16008	04996
Ensembl ID		ENSG00000183542	ENSG00000011600
Uniprot IDs		O43908	O43914 X6RGC9
PDB IDs		Not available	2L34 2L35 4WO1 4WOL 7Q5W
GO Terms Enriched among Interactors		Natural Killer Cell Lectin-like Receptor Binding Lymphocyte Activation Natural Killer Cell Mediated Immunity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Leukocyte Activation Positive Regulation Of Immune Response Cell Activation Regulation Of Leukocyte Mediated Cytotoxicity Lymphocyte Mediated Immunity Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway Leukocyte Mediated Immunity Negative Regulation Of Defense Response To Virus By Host Regulation Of Immune Response Positive Regulation Of Immune System Process Cell Killing Positive Regulation Of Osteoclast Development Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Macrophage Fusion Microglial Cell Activation Involved In Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response Positive Regulation Of Immune Effector Process Negative Regulation Of Transforming Growth Factor Beta1 Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery T Cell Activation T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Regulation Of Osteoclast Development External Side Of Plasma Membrane Immune Response-activating Signaling Pathway Neutrophil Activation Involved In Immune Response Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Transforming Growth Factor Beta Production Regulation Of Immune System Process Immune Effector Process Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune Response-regulating Signaling Pathway Activation Of Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Negative Regulation Of Defense Response To Virus Negative Regulation Of B Cell Proliferation Immune System Process Gamma-delta T Cell Activation Macrophage Activation Involved In Immune Response Regulation Of Superoxide Anion Generation Cellular Response To Lectin Positive Regulation Of Superoxide Anion Generation Stimulatory C-type Lectin Receptor Signaling Pathway	Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Transmembrane Signaling Receptor Activity Regulation Of Immune Response Immune System Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Membrane Regulation Of Innate Immune Response Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Beta Selection Positive Regulation Of Immune Effector Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Lymphocyte Mediated Immunity Immune Response-activating Signaling Pathway Positive Regulation Of Immune System Process Cellular Defense Response Regulation Of Cell Activation Signal Transduction Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Immune Response Carbohydrate Binding Innate Immune Response-activating Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of Calcium-mediated Signaling Regulation Of Natural Killer Cell Mediated Immunity Plasma Membrane Activation Of Immune Response Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Leukocyte Mediated Cytotoxicity Activation Of Innate Immune Response Positive Regulation Of Cell Killing Immune Response Scaffold Protein Binding Positive Regulation Of Defense Response Lymphocyte Activation Regulation Of Defense Response Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Defense Response Regulation Of Calcium-mediated Signaling Signaling Receptor Activity Regulation Of Leukocyte Mediated Cytotoxicity Leukocyte Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Phagocytosis Adaptive Immune Response