CAPNS1 and LRRCC1

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid)

		CAPNS1	LRRCC1
Name		calpain small subunit 1	leucine rich repeat and coiled-coil centrosomal protein 1
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Exosome Calpain Complex	Cytoplasm Centrosome Centriole Cytoskeleton
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Metal Ion Binding	None
	Biological Process	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy	Cell Division
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	None
Drugs		PD150606	None
GWAS		No GWAS studies recorded	Metabolite levels ( 23823483 )
Interacting Genes		21 interacting genes: AGTRAP ARHGEF6 ARR3 ATP5MF CAPN1 CAPN2 CAST CDC42 CDK4 DRG1 F2RL1 GET4 GNB2 IL2RG KCTD7 LRRCC1 PPARGC1A RAB1A STAT3 TERF1 TRAF5	4 interacting genes: C14orf119 CAPNS1 FADD NRIP1
Entrez ID		826	85444
HPRD ID		00240	11160
Ensembl ID		ENSG00000126247	ENSG00000133739
Uniprot IDs		A0A0C4DGQ5 P04632	B4DTJ0 Q9C099
PDB IDs		1KFU 1KFX 4PHJ 4PHK 4PHM 4WQ2 4WQ3 5D69 6QLB	Not available
GO Terms Enriched among Interactors		Calpain Complex Calcium-dependent Cysteine-type Endopeptidase Activity Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Endocytosis Thioesterase Binding Positive Regulation Of Phagocytosis Positive Regulation Of Interleukin-8 Production Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Cytosol Pseudopodium Regulation Of Interleukin-8 Production Cytoplasm Positive Regulation Of Cellular Component Organization Regulation Of Phagocytosis GTPase Activity Regulation Of Endocytosis LncRNA Binding Regulation Of Interleukin-6 Production Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Establishment Of Endothelial Barrier Positive Regulation Of Interleukin-10 Production Endothelial Cell Development Positive Regulation Of Renin Secretion Into Blood Stream Signal Transduction Involved In Regulation Of Gene Expression Temperature Homeostasis Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly	Calpain Complex Ovarian Follicle Rupture Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Ripoptosome Positive Regulation Of T Cell Extravasation Death Effector Domain Binding Receptor Serine/threonine Kinase Binding Negative Regulation Of Activation-induced Cell Death Of T Cells Regulation Of Activation-induced Cell Death Of T Cells Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation CD95 Death-inducing Signaling Complex Death-inducing Signaling Complex Assembly Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Death-inducing Signaling Complex Tumor Necrosis Factor Receptor Superfamily Binding Necroptotic Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Calcium-dependent Cysteine-type Endopeptidase Activity Nuclear Retinoid X Receptor Binding Ovulation Nuclear Glucocorticoid Receptor Binding Nuclear Retinoic Acid Receptor Binding Positive Regulation Of Macrophage Differentiation Positive Regulation Of Cellular Extravasation Death Receptor Binding Behavioral Response To Cocaine Motor Neuron Apoptotic Process Caspase Binding Positive Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Necroptotic Process Lymph Node Development Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Programmed Necrotic Cell Death