USP9X and GPSM1

Number of citations: 43 (PubMedID 20305814)
Data Source: BioGRID (pull down)

		USP9X	GPSM1
Name		ubiquitin specific peptidase 9 X-linked	G protein signaling modulator 1
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Cilium Membrane Growth Cone Cell Projection	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Cell Cortex Membrane Protein-containing Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K63-linked Deubiquitinase Activity Co-SMAD Binding Deubiquitinase Activity Molecular Sequestering Activity K11-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity	G-protein Alpha-subunit Binding GDP-dissociation Inhibitor Activity Protein Binding GTPase Regulator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration DNA Alkylation Repair Proteolysis Chromosome Segregation Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Intracellular Protein Localization Cell Migration Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Ubiquitination Protein Deubiquitination BMP Signaling Pathway Regulation Of Protein Stability Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Monoubiquitinated Protein Deubiquitination Regulation Of Circadian Rhythm Rhythmic Process Axon Extension Protein Stabilization Cell Division Cilium Assembly Cytosolic Ciliogenesis Protein K63-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cilium Assembly Positive Regulation Of TORC2 Signaling Amyloid Fibril Formation	Establishment Of Mitotic Spindle Orientation Nervous System Development Positive Regulation Of Macroautophagy Cell Differentiation Negative Regulation Of GTPase Activity Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes RHOU GTPase cycle RHOV GTPase cycle Peroxisomal protein import Peroxisomal protein import Amyloid fiber formation	G alpha (i) signalling events
GWAS		Migraine ( 27322543 )	Acute insulin response (insulin secretion adjusted) ( 28490609 ) Birth weight ( 31043758 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 ) Insulinogenic index ( 23263489 ) Joint damage in rheumatoid arthritis ( 26498133 ) Myocardial infarction ( 33532862 ) Offspring birth weight ( 31043758 ) Type 2 diabetes ( 23945395 32499647 31118516 30718926 30297969 29632382 28869590 26818947 ) Type 2 diabetes (adjusted for BMI) ( 29632382 ) Ulcerative colitis ( 28067908 ) White blood cell count ( 29403010 )
Interacting Genes		32 interacting genes: AFDN ALDH1A3 BCL9 CDC123 CTNNB1 DCX DDX3X DVL2 ERG GPSM1 MAP3K5 MCL1 NEAT1 NRP1 PEF1 PEX5 PSD4 PTEN RICTOR RNF115 RSPH1 SGTA SMAD2 SMAD4 SMN2 SMURF1 STIL SUMO2 TDRD3 TIAM1 UBC VHL	28 interacting genes: BHLHE40 CCDC158 CTDSP1 DAZAP2 DCAF11 DMRT3 FAM161B FAM83A FAM90A1 FXR2 GCM2 GLIS2 GNAI1 GNAI3 HMG20A INSC KANK2 MAP1LC3A OSTM1 RIBC1 SEPTIN1 TASOR2 TEKT4 TRIP13 USHBP1 USP9X VEZF1 ZBED1
Entrez ID		8239	26086
HPRD ID		02091	17075
Ensembl ID		ENSG00000124486	ENSG00000160360
Uniprot IDs		A0A994J4R6 A0A994J6S4 Q6P468 Q86X58 Q93008	A0A087WVF5 A0A0A0MSK4 Q86YR5
PDB IDs		5VBD 5WCH 7YXX 7YXY	Not available
GO Terms Enriched among Interactors		Cytoplasm Cytosol I-SMAD Binding Embryonic Axis Specification Positive Regulation Of Metabolic Process Developmental Process SMAD Binding Regulation Of Epithelial To Mesenchymal Transition Cellular Developmental Process Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Tissue Morphogenesis Cell Differentiation Activin Responsive Factor Complex Wnt Signaling Pathway Positive Regulation Of RNA Metabolic Process Axis Specification Positive Regulation Of Macromolecule Metabolic Process R-SMAD Binding Morphogenesis Of An Epithelium Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cranial Ganglion Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Protein Modification By Small Protein Conjugation Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Component Assembly SMAD Protein Complex Positive Regulation Of Catabolic Process Heteromeric SMAD Protein Complex Gastrulation Positive Regulation Of Growth Regulation Of Growth Non-canonical Wnt Signaling Pathway Positive Regulation Of Signal Transduction Sympathetic Ganglion Development Positive Regulation Of Developmental Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Embryonic Morphogenesis Post-translational Protein Modification Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Heart Development Embryonic Foregut Morphogenesis Regulation Of Axonogenesis Neuron Migration	None