SHARPIN and ITGA1

Number of citations: 59 (PubMedID 21947080)
Data Source: BioGRID (affinity chromatography technology, pull down)

		SHARPIN	ITGA1
Name		SHANK associated RH domain interactor	integrin subunit alpha 1
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Synapse LUBAC Complex	Acrosomal Vesicle Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin Alpha1-beta1 Complex Perikaryon Basal Part Of Cell Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein-macromolecule Adaptor Activity Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Metal Ion Binding	Signaling Receptor Binding Protein Binding Collagen Binding Phosphatase Activator Activity Protein Phosphatase Binding Signaling Receptor Activity Metal Ion Binding Collagen Binding Involved In Cell-matrix Adhesion
	Biological Process	Mitochondrion Organization Epidermis Development Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Apoptotic Nuclear Changes Keratinization Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Inflammatory Response Protein Linear Polyubiquitination Regulation Of CD40 Signaling Pathway	Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Negative Regulation Of Cell Population Proliferation Neutrophil Chemotaxis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vasodilation Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Apoptotic Process Cellular Extravasation Neuron Projection Morphogenesis Cell Chemotaxis Cell-cell Adhesion
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Neurexins and neuroligins	Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Other semaphorin interactions Smooth Muscle Contraction CHL1 interactions Platelet Adhesion to exposed collagen
GWAS		Asthma ( 31959851 32296059 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Neutrophil percentage of granulocytes ( 27863252 ) Serum metabolite levels ( 23093944 ) Sum eosinophil basophil counts ( 27863252 )	Acne (severe) ( 24927181 ) Alanine aminotransferase levels ( 33547301 ) Alzheimer's disease biomarkers ( 23419831 ) Apolipoprotein B levels ( 32203549 ) Attention deficit hyperactivity disorder ( 28809852 ) Chronic obstructive pulmonary disease ( 30804561 ) Coronary artery disease ( 26708285 ) FEV1 ( 30804560 ) Gamma glutamyl transferase levels ( 33339817 29403010 ) Heel bone mineral density ( 30598549 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 ) LDL cholesterol ( 30275531 ) LDL cholesterol levels ( 32203549 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514 ) Low density lipoprotein cholesterol levels ( 32154731 ) Lung function (FEV1/FVC) ( 30804560 28166213 ) Metabolite levels ( 23823483 ) Myocardial infarction ( 26708285 ) Peak expiratory flow ( 30804560 ) Pulmonary function ( 21946350 ) Pulmonary function (smoking interaction) ( 23284291 ) Pulse pressure ( 30578418 30224653 ) Red blood cell count ( 32888494 ) Response to platinum-based agents ( 22020760 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Serum alkaline phosphatase levels ( 33547301 ) Serum thyroid-stimulating hormone levels ( 25436638 ) Serum total protein levels ( 29403010 ) Total cholesterol levels ( 30275531 ) Type 2 diabetes ( 30297969 29926116 30718926 32499647 30130595 ) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408 )
Interacting Genes		30 interacting genes: ACTR2 ACTR3 FMR1 FXR1 ITGA1 ITGA2B ITGA5 ITGAD ITGAL ITGAM ITGB2 KRTAP6-2 KRTAP7-1 PPIL3 PTEN RBCK1 RNF26 RNF31 SHANK1 SHANK2 SHANK3 TIAM1 TNF TRAF1 TRIP13 TXN2 UBC USP54 YOD1 ZBTB32	10 interacting genes: AUP1 BIN1 COL13A1 COL8A1 ITGB1 LAMA1 MATN1 PTPN2 SHARPIN TLN1
Entrez ID		81858	3672
HPRD ID		15463	01892
Ensembl ID		ENSG00000179526	ENSG00000213949
Uniprot IDs		Q6PJD5 Q9H0F6	P56199
PDB IDs		4EMO 5X0W 8K6P	1PT6 1QC5 1QCY 2L8S 2M32 4A0Q 5HGJ
GO Terms Enriched among Interactors		Integrin Complex Cell-matrix Adhesion Cell-substrate Adhesion Integrin-mediated Signaling Pathway Synaptic Receptor Adaptor Activity Cellular Extravasation Dendritic Spine Positive Regulation Of Long-term Neuronal Synaptic Plasticity Heterotypic Cell-cell Adhesion Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Nervous System Process Leukocyte Cell-cell Adhesion Integrin AlphaL-beta2 Complex Integrin AlphaM-beta2 Complex Social Behavior Dendritic Spine Morphogenesis Postsynaptic Density Organization Signaling Receptor Activity Vocalization Behavior Regulation Of Translation At Presynapse, Modulating Synaptic Transmission ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Meiotic Chromosome Movement Towards Spindle Pole Cell Adhesion Cell Surface Postsynaptic Specialization Organization Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Long-term Neuronal Synaptic Plasticity Cognition Modulation Of Chemical Synaptic Transmission Negative Regulation Of Dopamine Metabolic Process Microglial Cell Activation LUBAC Complex Ionotropic Glutamate Receptor Binding Neuron Projection Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Leukocyte Activation Involved In Inflammatory Response External Side Of Plasma Membrane RNA Strand Annealing Activity Negative Regulation Of Catecholamine Metabolic Process Regulation Of Neurogenesis Positive Regulation Of Neurogenesis Positive Regulation Of Dendritic Spine Development Positive Regulation Of DNA-binding Transcription Factor Activity Postsynaptic Membrane Signal Transduction Intracellular Membraneless Organelle Regulation Of Neutrophil Degranulation	Cell Differentiation Extracellular Matrix Basement Membrane Cell Adhesion Integrin Binding Lipid Tube Assembly Regulation Of Multicellular Organismal Development Cellular Developmental Process Negative Regulation Of Cardiac Muscle Cell Contraction Lipid Tube Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Regulation Of Cell Adhesion Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen Trimer Collagen Type VIII Trimer Anatomical Structure Morphogenesis Collagen Type XIII Trimer Myoblast Fate Specification Integrin Alpha6-beta1 Complex Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Integrin Alpha8-beta1 Complex Integrin Alpha1-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alpha7-beta1 Complex Integrin Alphav-beta1 Complex Integrin Alpha11-beta1 Complex Cardiac Cell Fate Specification Integrin Alpha3-beta1 Complex Integrin Alpha9-beta1 Complex Growth Plate Cartilage Chondrocyte Morphogenesis Negative Regulation Of Interleukin-4-mediated Signaling Pathway Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Interleukin-2-mediated Signaling Pathway Protease Binding Developmental Process Ubiquitin Binding Lipophagy Cell-matrix Adhesion Ruffle Integrin-mediated Signaling Pathway Integrin Alpha4-beta1 Complex Integrin Alpha2-beta1 Complex Ruffle Membrane Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Laminin-1 Complex Laminin-3 Complex