MADCAM1 and ITGB7

Number of citations: 0 (PubMedID 9233649)
Data Source: BioGRID (pull down), HPRD (in vitro)

		MADCAM1	ITGB7
Name		mucosal vascular addressin cell adhesion molecule 1	integrin subunit beta 7
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Integrin Alpha4-beta7 Complex Receptor Complex Extracellular Exosome
	Molecular Function	Integrin Binding Involved In Cell-matrix Adhesion	Virus Receptor Activity Integrin Binding Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Positive Regulation Of Leukocyte Migration Immune Response Cell Adhesion Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Heterotypic Cell-cell Adhesion Receptor Clustering Leukocyte Tethering Or Rolling Positive Regulation Of Lymphocyte Migration	Immune Response In Gut-associated Lymphoid Tissue Cell-matrix Adhesion Involved In Ameboidal Cell Migration Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Receptor Clustering Symbiont Entry Into Host Cell Leukocyte Migration Leukocyte Tethering Or Rolling T Cell Migration Cell-cell Adhesion
Pathways		None	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions
Drugs		None	R1295 Vedolizumab Etrolizumab
GWAS		No GWAS studies recorded	Obesity-related traits ( 23251661 ) Type 1 diabetes ( 34127860 )
Interacting Genes		3 interacting genes: CD44 ITGA4 ITGB7	15 interacting genes: CDH1 DAB1 DOK1 EED FLNA FN1 ITGA4 ITGAE MADCAM1 PRKCB PRKCD RACK1 TLN1 TNS2 VCAM1
Entrez ID		8174	3695
HPRD ID		00035	00948
Ensembl ID		ENSG00000099866	ENSG00000139626
Uniprot IDs		Q13477	P26010
PDB IDs		1BQS 1GSM 4HBQ 4HC1 4HCR 4HD9	2BRQ 3V4P 3V4V 8ZJF
GO Terms Enriched among Interactors		Cell-matrix Adhesion Involved In Ameboidal Cell Migration Integrin Alpha4-beta7 Complex Leukocyte Cell-cell Adhesion Immune Response In Gut-associated Lymphoid Tissue Cell-matrix Adhesion Cell-substrate Adhesion Leukocyte Tethering Or Rolling Leukocyte Adhesion To Vascular Endothelial Cell Integrin Complex Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Receptor Clustering Focal Adhesion Cell-cell Adhesion Neuron Projection Extension Clathrin-dependent Extracellular Exosome Endocytosis Negative Regulation Of Protein Homodimerization Activity Cell Adhesion Molecule Binding Mannosyltransferase Complex Integrin-mediated Signaling Pathway Positive Regulation Of Monocyte Aggregation Cell Surface Regulation Of Signal Transduction By P53 Class Mediator Macrophage Migration Inhibitory Factor Receptor Complex Developmental Cell Growth Alpha-1,6-mannosyltransferase Activity Immune System Process Developmental Growth Involved In Morphogenesis Integrin Binding Cell Surface Receptor Signaling Pathway Monocyte Aggregation Integrin Alpha4-beta1 Complex Axonogenesis Intracellular Protein-containing Complex GPI Mannosyltransferase Activity Extracellular Exosome Cell Adhesion Positive Regulation Of Vesicle Transport Along Microtubule Cell Migration C-X3-C Chemokine Binding Leukocyte Migration LRR Domain Binding Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Diapedesis Cell-cell Adhesion Mediated By Integrin Cell Motility Neuron Projection Morphogenesis Positive Regulation Of Leukocyte Cell-cell Adhesion Cell Projection Morphogenesis	Cell-cell Adhesion Cell Adhesion Integrin-mediated Signaling Pathway Cell-matrix Adhesion Regulation Of Cell Adhesion Cell-substrate Adhesion Leukocyte Tethering Or Rolling Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Transport Cell Surface Receptor Signaling Pathway Heterotypic Cell-cell Adhesion Protein Kinase C Signaling Positive Regulation Of Protein Import Into Nucleus Cellular Response To Oxygen-containing Compound Positive Regulation Of Establishment Of Protein Localization Integrin Binding Cell Migration Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Receptor Clustering Cell-cell Adhesion Mediated By Integrin Leukocyte Cell-cell Adhesion Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport B Cell Activation Cell Motility Perinuclear Region Of Cytoplasm Extracellular Exosome Regulation Of Protein Transport Integrin Activation Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Protein Localization Regulation Of Cellular Response To Insulin Stimulus Enzyme Activator Activity Positive Regulation Of Intracellular Protein Transport Cell Adhesion Molecule Binding Positive Regulation Of Protein Localization To Nucleus Regulation Of Establishment Of Protein Localization Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Cell Migration Plasma Membrane Protein Activation Cascade Positive Regulation Of Cell Motility Protein Localization To Membrane Cadherin Binding Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Cell Motility