DIAPH3 and CDC42

Number of citations: 0 (PubMedID 31871319)
Data Source: BioGRID (affinity chromatography technology, pull down)

		DIAPH3	CDC42
Name		diaphanous related formin 3	cell division cycle 42
Structure
GO Annotations	Cellular Component	ESCRT I Complex Spindle Pole Nucleus Cytoplasm Microtubule Organizing Center Cytosol Actin Filament Filamentous Actin Cleavage Furrow Actin Filament Bundle Ribbon Synapse Stereocilia Tip-link Density	Golgi Membrane Storage Vacuole Cytoplasm Endoplasmic Reticulum Membrane Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Golgi Transport Complex Filopodium Dendrite Midbody Cell Leading Edge Leading Edge Membrane Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule Cell Projection Neuron Projection Neuronal Cell Body Apical Part Of Cell Phagocytic Vesicle Spindle Midzone Extracellular Exosome Cell Periphery Mitotic Spindle Postsynapse Glutamatergic Synapse
	Molecular Function	Actin Binding Microtubule Binding Cytoskeletal Protein Binding Small GTPase Binding Protein Homodimerization Activity Cadherin Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Protein Kinase Binding GTP-dependent Protein Binding Thioesterase Binding GBD Domain Binding Apolipoprotein A-I Receptor Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Microtubule Cytoskeleton Organization In Utero Embryonic Development Cytoskeleton Organization Actin Filament Organization Negative Regulation Of Microtubule Depolymerization Chromosome Segregation Integrin-mediated Signaling Pathway Sensory Perception Of Sound Gene Expression Endosomal Transport Establishment Of Cell Polarity Cell Projection Organization Actin Cytoskeleton Organization Actin Filament Polymerization Neuron Differentiation Erythrocyte Differentiation Macrophage Differentiation Protein-containing Complex Remodeling Erythrocyte Enucleation Actin Nucleation Microtubule Polymerization Actin Filament Bundle Assembly Actin Crosslink Formation Inner Ear Receptor Cell Differentiation Head Development Autophagosome-lysosome Fusion Podosome Assembly	Heart Process Cardiac Conduction System Development Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Endocytosis Phagocytosis, Engulfment Actin Filament Organization Golgi Organization Regulation Of Mitotic Nuclear Division Nuclear Migration Establishment Or Maintenance Of Cell Polarity Signal Transduction Integrin-mediated Signaling Pathway Small GTPase-mediated Signal Transduction Nervous System Development Intracellular Protein Localization Anatomical Structure Morphogenesis Regulation Of Lamellipodium Assembly Positive Regulation Of Lamellipodium Assembly Substantia Nigra Development Establishment Of Cell Polarity Actin Cytoskeleton Organization Cell Differentiation Macrophage Differentiation Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cytokinesis Regulation Of Actin Cytoskeleton Organization Cell Junction Assembly Adherens Junction Organization Embryonic Heart Tube Development Establishment Or Maintenance Of Apical/basal Cell Polarity Dendritic Cell Migration Neuropilin Signaling Pathway Positive Regulation Of MAPK Cascade Host-mediated Perturbation Of Viral Process Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Positive Regulation Of Pinocytosis Neuron Fate Determination Positive Regulation Of Cellular Component Organization Regulation Of Filopodium Assembly Positive Regulation Of Filopodium Assembly Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Nucleus Localization Establishment Of Localization In Cell Establishment Of Golgi Localization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Attachment Of Spindle Microtubules To Kinetochore Heart Contraction Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Dendritic Spine Morphogenesis Cellular Response To Type II Interferon Organelle Transport Along Microtubule Endothelin Receptor Signaling Pathway Involved In Heart Process Regulation Of Postsynapse Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		RHO GTPases Activate Formins RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle	GPVI-mediated activation cascade EGFR downregulation Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation CD28 dependent Vav1 pathway EPHB-mediated forward signaling EPHB-mediated forward signaling DCC mediated attractive signaling Inactivation of CDC42 and RAC1 VEGFA-VEGFR2 Pathway Myogenesis Myogenesis RHO GTPases activate KTN1 RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAPK6/MAPK4 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation G beta:gamma signalling through CDC42 CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production
Drugs		None	Aminophosphonic acid-guanylate ester Guanosine-5'-Diphosphate
GWAS		Age at first sexual intercourse ( 27089180 34211149 ) Body mass index ( 28892062 ) Breast milk fatty acid composition (infant genotype effect) ( 29514873 ) Breast milk fatty acid composition (maternal genotype effect) ( 29514873 ) Chronotype ( 30696823 ) General risk tolerance (MTAG) ( 30643258 ) Gut microbiota (functional units) ( 27694959 ) HOMA-B (corrected for HOMA-IR) ( 30369944 ) Metabolite levels ( 23823483 ) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095 ) Number of sexual partners ( 30643258 ) Smoking initiation ( 33082346 ) Smoking status (ever vs never smokers) ( 30643258 )	Colorectal cancer ( 25990418 ) Daytime sleep phenotypes ( 27126917 ) Extremely high intelligence ( 29520040 ) Gestational age at birth (maternal effect) ( 28877031 ) Gynecologic disease ( 31488892 ) Gynecologic disease (multivariate analysis) ( 31488892 ) Hip circumference adjusted for BMI ( 34021172 ) Immune response to smallpox vaccine (IL-6) ( 22610502 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Metabolite levels ( 23823483 ) Uterine fibroids ( 30194396 31249589 31488892 31649266 ) Uterine fibroids (MTAG) ( 31488892 )
Interacting Genes		6 interacting genes: CDC42 NCKIPSD PDCD6 RAC1 RHOA SMAD9	383 interacting genes: A2M AARS1 ACADM ACO1 ACO2 ACOT7 ACTR3 ADRM1 AGAP1 AGAP2 AHSG AKR1B1 ALDH18A1 ANAPC13 ANXA11 ANXA2 AP3D1 APEX1 APOH ARAP1 ARAP2 ARG1 ARHGAP1 ARHGAP10 ARHGAP11B ARHGAP17 ARHGAP20 ARHGAP22 ARHGAP26 ARHGAP27 ARHGAP31 ARHGAP32 ARHGAP35 ARHGAP39 ARHGAP40 ARHGAP44 ARHGDIA ARHGDIB ARHGDIG ARHGEF10 ARHGEF11 ARHGEF15 ARHGEF25 ARHGEF26 ARHGEF4 ARHGEF6 ARHGEF7 ARHGEF9 ARRB1 ARRB2 ATP5F1C ATP5IF1 ATP5MF ATP5PD ATP6V1A BAIAP2 BCAP31 BCCIP BCL2L13 BCR BIRC2 BLMH BNIP2 BRD10 BTF3 BZW2 CALML5 CAPNS1 CAPZB CARHSP1 CASP14 CASP3 CASP7 CBLL1 CBX3 CCN1 CDC42BPA CDC42BPB CDC42BPG CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 CDC42EP5 CDC42SE1 CDC5L CDH1 CDKN2A CEBPA CFHR4 CGN CMPK1 CNBP CNOT1 COL1A1 COMT COPA COPE COPG1 CPN1 CRIP2 CSE1L CSN2 CSPG4 CTNNA1 DEF6 DEK DHFR DIAPH1 DIAPH2 DIAPH3 DNMBP DOCK7 DOCK8 DOCK9 DPYSL2 DSG1 DSP ECHS1 EDC4 EDF1 EEF1E1 EEF1G EHD2 EHD4 EIF2AK2 EIF3D EIF3F EIF5 EIF5B EPHA2 EPRS1 ERCC3 ERG28 ERICH6 ERRFI1 ETFA FAM13B FGD1 FGD2 FGD3 FGD4 FKBP10 FKBP1A FKBP3 FLNA FLNC FMN2 FMNL2 FNBP1 FNBP1L FNDC3B FTH1 G6PD GALNT2 GART GDI1 GIT2 GLS GMIP GNB1 GRB2 GRWD1 GSR GSTM5 H1-10 H1-5 H2BC13 HADH HADHB HDAC7 HDLBP HERC2 HLA-G HMGN1 HNRNPAB HNRNPUL2 HSD17B10 HYOU1 IARS1 IGF2BP1 IPO5 IQGAP1 IQGAP2 ITSN1 JPT2 KARS1 KAT5 KHDRBS1 KPNA2 KTN1 KYNU LARS1 LCK LGALS1 LGALS7 LONP1 LRIF1 LRP2 LYZ MAP2K3 MAP3K10 MAP3K11 MAP3K19 MAP3K4 MAP4 MAPRE1 MARCKSL1 MARK4 MASTL MATR3 MCF2L MCM3AP MCM6 MCM7 MDH1 MDK METAP2 MRM1 MRPL49 MSH2 MT-CO1 MTDH MUC12 MYO1C MYO6 MYO9A NAA15 NASP NCAPD2 NCF2 NEK6 NIBAN2 NOP2 NPLOC4 NQO1 NUDT21 NUP155 OCRL OLA1 OPHN1 P3H1 PABPC4 PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PALLD PARD3 PARD6A PARD6B PARD6G PAXX PCM1 PCNP PDCD5 PDE6C PDE6D PGD PGGT1B PHAX PHB2 PHPT1 PICALM PIK3R1 PLD1 PLEKHG1 PLEKHG2 PLEKHG3 PLEKHG4 PLEKHG4B PMS1 PPP2R1A PRDX3 PREX2 PRKCA PRKCG PRKCI PRKCZ PSAT1 PSIP1 PSMB1 PSMC5 PSMC6 PSMD11 PSMD12 PSMD3 PSME3 PXDN RAC2 RAP1GDS1 RARS1 RASGRF2 RBM8A RHOJ RIOK3 RO60 RPL22 RPL23 RPS15 RPS21 RPS6KB1 RRM1 S100A9 SDHA SEPTIN2 SERPINB1 SERPINB2 SERPINB3 SF1 SF3A2 SH3BGRL3 SH3D19 SLC16A3 SMC2 SNCA SNRNP70 SPATA13 SRGAP1 SRM SRP72 SRSF1 SSB SSX2IP ST13 STARD8 STAT1 STAU1 STMN2 SYNE1 TBC1D3F TBCA TCEAL3 TIAM1 TMED10 TMED9 TMOD3 TMX1 TNFRSF10B TNK2 TOR1AIP1 TP53 TPD52L2 TPM1 TRAF2 TRIM28 TRIM45 TRIM60 TRIO TRIP10 TRRAP TSFM TTC12 TUBB3 TXNL1 TYMS U2AF2 UBC UBE2L3 UBR1 UGDH UNC119 USP6 VARS1 VASP VAV1 VRK2 WAS WASF1 WASF2 WASL WIPF1 XIAP XPO1 YARS1 YWHAH ZNF175 ZNF234 ZNF415 ZNF420 ZNF622
Entrez ID		81624	998
HPRD ID		10884	00309
Ensembl ID		ENSG00000139734	ENSG00000070831
Uniprot IDs		B4DPV3 Q9NSV4	P60953
PDB IDs		5UWP 6X2Y	1A4R 1AJE 1AM4 1AN0 1CEE 1CF4 1DOA 1E0A 1EES 1GRN 1GZS 1KI1 1KZ7 1KZG 1NF3 2ASE 2DFK 2KB0 2NGR 2ODB 2QRZ 2WM9 2WMN 2WMO 3GCG 3QBV 3VHL 4DID 4ITR 4JS0 4YC7 4YDH 5CJP 5FI1 5HZK 5UPK 5UPL 6AJ4 6AJL 6SIU 6SUP 6TKY 6TKZ 7S0Y 8I5F
GO Terms Enriched among Interactors		Postsynapse Positive Regulation Of Stress Fiber Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Synapse Organization G Protein Activity G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Stress Fiber Assembly Thioesterase Binding Regulation Of Postsynapse Organization Positive Regulation Of Cell Migration Establishment Or Maintenance Of Cell Polarity Establishment Of Epithelial Cell Apical/basal Polarity Glutamatergic Synapse Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cell Motility Cell-cell Junction Organization Positive Regulation Of Locomotion GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Positive Regulation Of Cytoskeleton Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Endothelial Cell Migration Polarized Epithelial Cell Differentiation Regulation Of Cell Projection Organization Positive Regulation Of Lamellipodium Assembly Regulation Of Cell-substrate Adhesion Establishment Of Epithelial Cell Polarity Cerebral Cortex Cell Migration Phagocytosis, Engulfment Positive Regulation Of Lamellipodium Organization Regulation Of Cell Junction Assembly Actin Filament Organization Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction Regulation Of Lamellipodium Assembly Wnt Signaling Pathway Telencephalon Cell Migration Intracellular Signaling Cassette Semaphorin-plexin Signaling Pathway Positive Regulation Of Cytokinesis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Substantia Nigra Development Regulation Of Postsynapse Assembly Substrate Adhesion-dependent Cell Spreading Forebrain Cell Migration	Cytosol Cytoplasm Regulation Of Small GTPase Mediated Signal Transduction GTPase Activator Activity Regulation Of Intracellular Signal Transduction Small GTPase Binding Guanyl-nucleotide Exchange Factor Activity Actin Filament-based Process Small GTPase-mediated Signal Transduction Actin Cytoskeleton Organization Intracellular Signaling Cassette Lamellipodium Intracellular Signal Transduction Regulation Of Signal Transduction Cytoskeleton Organization RNA Binding Regulation Of Signaling Regulation Of Cell Communication Rho Protein Signal Transduction Extracellular Exosome Organelle Organization Cadherin Binding Cell-cell Junction Regulation Of Actin Cytoskeleton Organization Cell Projection Organization Cell Cortex PAR Polarity Complex Biological_process Regulation Of Actin Filament-based Process Ruffle Actin Filament Organization Regulation Of Cytoskeleton Organization Regulation Of Cell Shape Regulation Of Cellular Component Organization Protein Serine Kinase Activity Supramolecular Fiber Organization Anchoring Junction Regulation Of Protein Metabolic Process Actin Cytoskeleton Cellular Component Assembly Regulation Of Programmed Cell Death Regulation Of Actin Filament Organization Actin Binding Cytoskeleton Positive Regulation Of Cellular Component Organization Regulation Of Supramolecular Fiber Organization Regulation Of Cell Morphogenesis Actin Filament Protein Serine/threonine Kinase Activity Regulation Of Rho Protein Signal Transduction