ITM2C and STT3A

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid)

		ITM2C	STT3A
Name		integral membrane protein 2C	STT3 oligosaccharyltransferase complex catalytic subunit A
Structure		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Golgi Apparatus Plasma Membrane Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex Membrane Oligosaccharyltransferase Complex A
	Molecular Function	Amyloid-beta Binding Protein Binding ATP Binding	Oligosaccharyl Transferase Activity Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Neuron Projection Development Neuron Differentiation Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Glycosylation Protein N-linked Glycosylation Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification
Pathways		None	Asparagine N-linked glycosylation Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PD-L1(CD274) glycosylation and translocation to plasma membrane
GWAS		Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 )	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885 ) Breast cancer (survival) ( 25890600 ) Schizophrenia ( 21926974 )
Interacting Genes		12 interacting genes: BACE1 CCL4L2 CFTR CXCL9 FNDC9 FURIN MTNR1B OLFM4 RNF7 SLC22A2 STT3A UPK2	7 interacting genes: CSDE1 HJURP IRAK2 ITM2C SARM1 STING1 USP40
Entrez ID		81618	3703
HPRD ID		17167	03086
Ensembl ID		ENSG00000135916	ENSG00000134910
Uniprot IDs		B8ZZM6 Q9NQX7	P46977
PDB IDs		Not available	6S7O 8B6L 8PN9
GO Terms Enriched among Interactors		None	Signaling Adaptor Activity NADP+ Nucleosidase Activity Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Extrinsic Component Of Synaptic Membrane NAD+ Nucleosidase Activity Cyclic-di-GMP Binding STING Complex Regulation Of Innate Immune Response Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway NAD+ Catabolic Process 2',3'-cyclic GMP-AMP Binding