URM1 and ASCC2

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		URM1	ASCC2
Name		ubiquitin related modifier 1	activating signal cointegrator 1 complex subunit 2
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Nuclear Speck Cytosolic Ribosome RQC-trigger Complex DNA Repair Complex
	Molecular Function	Protein Binding Protein Tag Activity Sulfur Carrier Activity	Protein Binding Ubiquitin Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	TRNA Wobble Uridine Modification TRNA Processing Protein Urmylation TRNA Thio-modification	DNA Replication DNA Repair DNA Alkylation Repair Regulation Of DNA-templated Transcription DNA Damage Response Ribosome Disassembly Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process
Pathways		tRNA modification in the nucleus and cytosol	ALKBH3 mediated reversal of alkylation damage ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
GWAS		Body mass index ( 26426971 )	Bipolar disorder or attention deficit hyperactivity disorder ( 27890468 ) Crohn's disease ( 28067908 ) Hemoglobin levels ( 32327693 ) IgA levels ( 28628107 ) Immature fraction of reticulocytes ( 27863252 ) Inflammatory bowel disease ( 28067908 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Refractive error ( 32231278 ) Spleen volume ( 34128465 ) Telomere length ( 24478790 ) Tonsillectomy ( 27941131 ) Type 2 diabetes ( 30297969 ) Type 2 diabetes (adjusted for BMI) ( 29632382 )
Interacting Genes		3 interacting genes: ASCC2 CDK11B TBL3	41 interacting genes: ASS1 CKAP4 CUTC DEAF1 EEF1D ELAC2 FAF1 FBP1 FUNDC2 GADD45A GFER GNL3 GTF3C1 IGSF9 IMMT KATNAL1 KDM1A LPL MAP3K1 MED31 MYH9 OLA1 PCBD2 PIK3CD PIN4 PJA1 POLA2 POLDIP2 PRPF18 RADIL RNF11 RPA1 RPLP1 SASH1 SMURF1 SNRPB SNW1 TBC1D17 TRIP4 UBC URM1
Entrez ID		81605	84164
HPRD ID		12976	16515
Ensembl ID		ENSG00000167118	ENSG00000100325
Uniprot IDs		Q9BTM9	Q9H1I8
PDB IDs		Not available	2DI0 6YXQ
GO Terms Enriched among Interactors		Endonucleolytic Cleavage To Generate Mature 5'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage In 5'-ETS Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) 90S Preribosome U3 SnoRNA Binding Ribosome-associated Ubiquitin-dependent Protein Catabolic Process DNA Alkylation Repair RQC-trigger Complex DNA Repair Complex Endonucleolytic Cleavage Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Cyclin-dependent Protein Serine/threonine Kinase Activity K63-linked Polyubiquitin Modification-dependent Protein Binding	Macromolecule Metabolic Process Nucleoplasm