CAMK4 and CAMKK1

Number of citations: 0 (PubMedID 7615569)
Data Source: HPRD (in vitro)

		CAMK4	CAMKK1
Name		calcium/calmodulin dependent protein kinase IV	calcium/calmodulin dependent protein kinase kinase 1
Structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Adaptive Immune Response Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Protein Phosphorylation Inflammatory Response Signal Transduction Long-term Memory Regulation Of T Cell Differentiation In Thymus Intracellular Signal Transduction Myeloid Dendritic Cell Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of DNA-templated Transcription	Intracellular Signal Transduction
Pathways		CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB Transcriptional activation of mitochondrial biogenesis CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Loss of phosphorylation of MECP2 at T308 Regulation of MECP2 expression and activity Negative regulation of NMDA receptor-mediated neuronal transmission	CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs
Drugs		K-00546 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one	Fostamatinib
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011 ) Allergic rhinitis ( 30013184 ) Allergic sensitization ( 23817571 ) Allergy ( 27182965 ) Alzheimer's disease (cognitive decline) ( 23535033 ) Asthma ( 30929738 31959851 31619474 ) Asthma (childhood onset) ( 30929738 ) Asthma onset (childhood vs adult) ( 30929738 ) Autoimmune thyroid disease ( 32581359 ) Blood pressure ( 17903302 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Medication use (thyroid preparations) ( 31015401 ) Motor coordination ( 34177493 ) Periodontitis (PAL4Q3) ( 24024966 ) Self-reported allergy ( 23817569 ) Type 1 diabetes ( 34012112 )	Serum alkaline phosphatase levels ( 33339817 ) Smoking behavior ( 19247474 )
Interacting Genes		10 interacting genes: CABIN1 CAMKK1 CAMKK2 CREBBP GAPDH HDAC4 NEDD4 NOS1 NOTCH1 RELA	10 interacting genes: AKT1 APP CALM1 CAMK1 CAMK1D CAMK4 CFTR PRKAA1 SGK1 YWHAG
Entrez ID		814	84254
HPRD ID		07169	13000
Ensembl ID		ENSG00000152495	ENSG00000004660
Uniprot IDs		Q16566	J3KPJ3 Q8N5S9
PDB IDs		2W4O	6CCF 6CD6
GO Terms Enriched among Interactors		Peptidyl-cysteine S-nitrosylase Activity Chromatin DNA Binding Nucleus Nucleoplasm Cytosol Endocardial Cushion Development Negative Regulation Of Myotube Differentiation Response To Muramyl Dipeptide Calcium/calmodulin-dependent Protein Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Signal Transduction Response To UV Response To Stress Regulation Of Protein Sumoylation Negative Regulation Of Biosynthetic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Binding Regulation Of Gene Expression NADP Binding Calmodulin Binding Positive Regulation Of Glial Cell Differentiation Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Regulation Of Myotube Differentiation Rhythmic Process Transcription Coactivator Binding Negative Regulation Of Metabolic Process Immune System Process Positive Regulation Of Transcription By RNA Polymerase II Canonical NF-kappaB Signal Transduction Catabolic Process Mesenchyme Development Formation Of Structure Involved In A Symbiotic Process Cellular Response To Growth Factor Stimulus Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Venous Endothelial Cell Differentiation	Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Regulation Of Transport Calcium/calmodulin-dependent Protein Kinase Activity Protein K6-linked Ubiquitination Kinase Activity Intracellular Signal Transduction ATP Binding Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Positive Regulation Of Transport Positive Regulation Of Protein Localization Cellular Response To Oxygen-containing Compound Calmodulin Binding Regulation Of Protein Localization Cellular Response To Amino Acid Starvation Regulation Of Developmental Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Ketone Negative Regulation Of TORC1 Signaling Response To Amino Acid Starvation Positive Regulation Of TORC1 Signaling TORC1 Signaling Chloride Channel Regulator Activity Regulation Of Vesicle-mediated Transport Positive Regulation Of Immune System Process Regulation Of Phosphorus Metabolic Process Nucleotide Binding Response To Alcohol Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell TOR Signaling Positive Regulation Of TOR Signaling Regulation Of Cell Activation Negative Regulation Of TOR Signaling Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of Phosphate Metabolic Process Regulation Of TORC1 Signaling Positive Regulation Of Establishment Of Protein Localization Regulation Of Multicellular Organismal Process Response To Metal Ion Regulation Of Translational Initiation Signal Transduction Negative Regulation Of Immune Response To Tumor Cell Cellular Response To Hormone Stimulus Protein Phosphorylation Protein-containing Complex Regulation Of T Cell Mediated Immune Response To Tumor Cell Response To Stress Memory