PDHX and PDHB

Number of citations: 0 (PubMedID 7864652)
Data Source: HPRD (in vivo)

		PDHX	PDHB
Name		pyruvate dehydrogenase complex component X	pyruvate dehydrogenase E1 subunit beta
Structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Pyruvate Dehydrogenase Complex	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex
	Molecular Function	Dihydrolipoyllysine-residue Acetyltransferase Activity Protein Binding Acyltransferase Activity	Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding Oxidoreductase Activity Metal Ion Binding
	Biological Process	Pyruvate Decarboxylation To Acetyl-CoA	Glucose Metabolic Process Pyruvate Decarboxylation To Acetyl-CoA Tricarboxylic Acid Cycle Purine-containing Compound Biosynthetic Process
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid PDH complex synthesizes acetyl-CoA from PYR	Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid Mitochondrial protein degradation PDH complex synthesizes acetyl-CoA from PYR
Drugs		None	Pyruvic acid NADH
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome	Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Bone mineral density (hip) ( 30172743 ) Heel bone mineral density ( 30598549 ) Systemic lupus erythematosus ( 28714469 ) Type 2 diabetes ( 30297969 ) Uterine fibroids ( 30194396 31649266 )	Apolipoprotein B levels ( 32203549 ) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107 ) IgG levels ( 28628107 ) LDL cholesterol levels ( 32203549 ) Refractive error ( 32231278 ) Systemic lupus erythematosus ( 26502338 28714469 ) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926 ) vWF levels ( 30586737 )
Interacting Genes		11 interacting genes: ACTN1 AGTRAP CIDEB DLAT DLD EP300 EWSR1 HSD17B10 OGT PDHB PDK2	18 interacting genes: ADORA2A AKT1 ANXA7 CDKN1A FCER1A GNB2 GRB7 HSD17B10 ITGB1 PDHA1 PDHA2 PDHX PFDN1 RAP1B RBM11 RCC1 TRIM63 TSC22D1
Entrez ID		8050	5162
HPRD ID		02002	01530
Ensembl ID		ENSG00000110435	ENSG00000168291
Uniprot IDs		A0A8C8MSB2 O00330	A0A384MDR8 P11177
PDB IDs		1ZY8 2DNC 2F5Z 2F60 6H60	1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI 6CER 6CFO
GO Terms Enriched among Interactors		Pyruvate Dehydrogenase Complex Pyruvate Decarboxylation To Acetyl-CoA Acetyl-CoA Biosynthetic Process Pyruvate Metabolic Process Acetyl-CoA Metabolic Process Glucose Metabolic Process Hexose Metabolic Process Mitochondrial Matrix Monosaccharide Metabolic Process Regulation Of Gluconeogenesis Monocarboxylic Acid Metabolic Process Acyl-CoA Metabolic Process Sulfur Compound Biosynthetic Process Regulation Of Glucose Metabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Acetyltransferase Activity Branched-chain Amino Acid Catabolic Process Carbohydrate Metabolic Process Amide Biosynthetic Process Platelet Formation Small Molecule Metabolic Process Histone Acetyltransferase Complex Branched-chain Amino Acid Metabolic Process Purine-containing Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Tricarboxylic Acid Cycle Response To Nutrient Levels Mitochondrion Cellular Response To Nutrient Nucleoside Phosphate Metabolic Process Carboxylic Acid Catabolic Process Purine-containing Compound Biosynthetic Process Nucleobase-containing Small Molecule Metabolic Process Sulfur Compound Metabolic Process Dihydrolipoyl Dehydrogenase (NADH) Activity 2-oxoglutarate Decarboxylation To Succinyl-CoA Acetyltransferase Complex Peptidyl-lysine Propionylation Regulation Of Glycolytic Process Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Cellular Response To Nutrient Levels Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Histone Crotonyltransferase Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity	Pyruvate Decarboxylation To Acetyl-CoA Pyruvate Dehydrogenase Complex Acetyl-CoA Biosynthetic Process Pyruvate Dehydrogenase (acetyl-transferring) Activity Acetyl-CoA Metabolic Process Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, Disulfide As Acceptor Protein-containing Complex Binding Pyruvate Metabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Fibroblast Migration Acyl-CoA Metabolic Process Sulfur Compound Biosynthetic Process Positive Regulation Of Amino Acid Transport Cell Migration Involved In Sprouting Angiogenesis Glucose Metabolic Process Cellular Response To Low-density Lipoprotein Particle Stimulus Tricarboxylic Acid Cycle Amide Biosynthetic Process Cellular Response To Lipoprotein Particle Stimulus Regulation Of Fibroblast Migration Carboxylic Acid Metabolic Process TRNA Methylation Organic Acid Metabolic Process Monosaccharide Metabolic Process Hexose Metabolic Process Blood Vessel Endothelial Cell Migration Regulation Of TRNA Methylation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition High-affinity IgE Receptor Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Mitochondrial Matrix Myoblast Fate Specification Integrin Alpha7-beta1 Complex Cellular Defense Response Protein Kinase Binding Monocarboxylic Acid Metabolic Process Excitatory Postsynaptic Potential Cellular Response To Amino Acid Starvation Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Localization To Lysosome PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Type I Hypersensitivity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity