WDR82 and PPP1R10

Number of citations: 59 (PubMedID 20516061)
Data Source: BioGRID (affinity chromatography technology, pull down)

		WDR82	PPP1R10
Name		WD repeat domain 82	protein phosphatase 1 regulatory subunit 10
Structure		No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Histone Methyltransferase Complex Set1C/COMPASS Complex PTW/PP1 Phosphatase Complex	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Nuclear Body PTW/PP1 Phosphatase Complex
	Molecular Function	Chromatin Binding Protein Binding LncRNA Binding	DNA Binding RNA Binding Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase 1 Binding Zinc Ion Binding Protein Phosphatase Regulator Activity Metal Ion Binding Enzyme-substrate Adaptor Activity
	Biological Process	RNA Polymerase II Promoter Clearance DNA-templated Transcription Termination Gene Expression Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II Nuclear RNA Surveillance LncRNA Catabolic Process Negative Regulation Of LncRNA Transcription	RNA Polymerase II Promoter Clearance Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Protein Import Into Nucleus Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Telomere Maintenance Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Transcription Elongation By RNA Polymerase II Protein Stabilization Negative Regulation Of Mitotic DNA Damage Checkpoint Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled
Pathways		Formation of WDR5-containing histone-modifying complexes Nuclear RNA decay	None
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 ) Bipolar disorder ( 21926972 ) General cognitive ability ( 29844566 ) Schizophrenia ( 23974872 ) Urate levels ( 31578528 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Autism spectrum disorder or schizophrenia ( 28540026 ) Mean corpuscular volume ( 27863252 ) Schizophrenia ( 30285260 )
Interacting Genes		9 interacting genes: CEBPA EP300 NAGK OSGEP PPP1CA PPP1R10 SETD1B TOX4 TP53	7 interacting genes: APP HNRNPK MDM2 PPP1CA PRKACA UBC WDR82
Entrez ID		80335	5514
HPRD ID		15183	04797
Ensembl ID		ENSG00000164091	ENSG00000204569
Uniprot IDs		Q6UXN9	Q2L6I0 Q96QC0
PDB IDs		Not available	6ZV2 8SW5
GO Terms Enriched among Interactors		RNA Polymerase II Promoter Clearance PTW/PP1 Phosphatase Complex Nucleobase-containing Compound Biosynthetic Process RNA Metabolic Process Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled DNA-templated Transcription Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Carbohydrate Catabolic Process Protein Stabilization Positive Regulation Of DNA-templated Transcription, Elongation Nucleic Acid Metabolic Process Chromatin DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Generation Of Precursor Metabolites And Energy STAT Family Protein Binding Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Glucose Metabolic Process Lung Development Regulation Of DNA-templated Transcription Elongation Macromolecule Biosynthetic Process Regulation Of Protein Stability Carbohydrate Metabolic Process Circadian Rhythm Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Transcription Elongation By RNA Polymerase II Protein Phosphatase 1 Binding Negative Regulation Of Stem Cell Proliferation Positive Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription, Elongation Chromosome, Telomeric Region Photoperiodism Entrainment Of Circadian Clock Chromatin RNA Polymerase II-specific DNA-binding Transcription Factor Binding T Cell Lineage Commitment Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein-containing Complex Disassembly Transcription Regulator Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Macromolecule Metabolic Process Chromosome Somitogenesis	Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Promoter Clearance PTW/PP1 Phosphatase Complex Regulation Of Apoptotic Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Response To Lead Ion Negative Regulation Of Macromolecule Biosynthetic Process Transition Metal Ion Binding Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Protein Export From Nucleus Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription, Elongation Amyloid Fibril Formation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Postsynaptic Modulation Of Chemical Synaptic Transmission Protein Domain Specific Binding Postsynapse Positive Regulation Of Biosynthetic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Metabolic Process Regulation Of Blood Circulation Positive Regulation Of Protein Transport Ribonucleoprotein Complex Binding Regulation Of Protein Export From Nucleus Macromolecule Metabolic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Metal Ion Response To Light Stimulus Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Calcium-mediated Signaling Regulation Of Glycolytic Process Regulation Of Small Molecule Metabolic Process Regulation Of Endocytosis Ubiquitin Protein Ligase Binding Regulation Of Protein Processing Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Maturation Positive Regulation Of DNA-templated Transcription, Elongation Amyloid-beta Complex Positive Regulation Of Metabolic Process Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion