MED28 and MED30

Number of citations: 106 (PubMedID 35271311)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology), HPRD (two hybrid, in vitro, in vivo)

		MED28	MED30
Name		mediator complex subunit 28	mediator complex subunit 30
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Membrane Mediator Complex Cortical Actin Cytoskeleton Core Mediator Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Mediator Complex Core Mediator Complex
	Molecular Function	Actin Binding Protein Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Nuclear Vitamin D Receptor Binding Nuclear Thyroid Hormone Receptor Binding Ubiquitin Protein Ligase Activity
	Biological Process	Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance RNA Polymerase II Preinitiation Complex Assembly Negative Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Transcription Initiation By RNA Polymerase II	Protein Ubiquitination Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance Positive Regulation Of DNA-templated Transcription RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
GWAS		No GWAS studies recorded	Common carotid intima-media thickness ( 29206233 ) Common carotid intima-media thickness in HIV infection ( 29206233 ) Dimensional psychopathology (Arousal) ( 29496196 ) Facial attractiveness (female raters) ( 30946739 ) Fasting blood glucose ( 29212154 ) Kawasaki disease ( 22446961 ) Leprosy ( 27976721 ) Midgestational total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095 ) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Urate levels in obese individuals ( 25811787 ) Vestibular neuritis ( 30079052 )
Interacting Genes		18 interacting genes: CBY2 CEBPA FYN GRB2 KLHL12 LCK MAGEA11 MED30 MED8 MED9 MIIP NF2 PRMT6 PUF60 SRC SUOX TCP11 USHBP1	17 interacting genes: APP DOCK8 HGS IFT20 KRTAP10-9 MED17 MED22 MED27 MED28 MED4 MED8 MED9 MTA2 NAP1L2 NME7 PCBD2 SS18L1
Entrez ID		80306	90390
HPRD ID		14381	11631
Ensembl ID		ENSG00000118579	ENSG00000164758
Uniprot IDs		Q9H204	Q96HR3
PDB IDs		7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH	7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
GO Terms Enriched among Interactors		Phospholipase Activator Activity T Cell Costimulation Positive Regulation Of DNA-templated Transcription Initiation Phospholipase Binding Regulation Of DNA-templated Transcription Initiation Core Mediator Complex Ephrin Receptor Binding CD8 Receptor Binding Fc-gamma Receptor Signaling Pathway Mediator Complex Non-membrane Spanning Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation RNA Polymerase II Preinitiation Complex Assembly Regulation Of Protein Localization To Nucleus Fc Receptor Signaling Pathway Positive Regulation Of Transcription Elongation By RNA Polymerase II CD4 Receptor Binding Transcription Preinitiation Complex Assembly Protein-containing Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Cell Activation T Cell Receptor Binding Scaffold Protein Binding Regulation Of Transcription Initiation By RNA Polymerase II Identical Protein Binding Activation Of Immune Response Protein-containing Complex Organization Interleukin-6-mediated Signaling Pathway Phosphatidylinositol 3-kinase Binding Protein Phosphatase Binding Regulation Of Transcription Elongation By RNA Polymerase II Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of T Cell Activation Angiotensin-activated Signaling Pathway Regulation Of DNA-templated Transcription Elongation Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Regulation Of Cell-cell Adhesion Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Leukocyte Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Protein Import Into Mitochondrial Matrix Response To Xenobiotic Stimulus Disordered Domain Specific Binding	Core Mediator Complex Mediator Complex RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Elongation By RNA Polymerase II Protein-DNA Complex Assembly Regulation Of DNA-templated Transcription Elongation Transcription Coregulator Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Cellular Component Assembly Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein-containing Complex Assembly Protein-containing Complex Organization Positive Regulation Of Macromolecule Metabolic Process Transcription Coactivator Activity Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Somatic Stem Cell Population Maintenance Regulation Of RNA Metabolic Process Nuclear Vitamin D Receptor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin Ligase Complex Stem Cell Population Maintenance Maintenance Of Cell Number Regulation Of Gene Expression Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Nuclear Thyroid Hormone Receptor Binding Regulation Of Primary Metabolic Process Positive Regulation Of T Cell Migration Transport Along Microtubule Amyloid-beta Complex Growth Cone Lamellipodium Cytoskeleton-dependent Intracellular Transport Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway