RMI1 and PFDN1

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		RMI1	PFDN1
Name		RecQ mediated genome instability 1	prefoldin subunit 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body RecQ Family Helicase-topoisomerase III Complex	Cytoplasm Prefoldin Complex Protein-containing Complex
	Molecular Function	Nucleotide Binding Protein Binding	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Homologous Recombination Response To Dietary Excess Reduction Of Food Intake In Response To Dietary Excess DNA Replication Response To Glucose Multicellular Organism Growth Glucose Homeostasis Resolution Of DNA Recombination Intermediates	Protein Folding Negative Regulation Of Amyloid Fibril Formation
Pathways		HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2	Prefoldin mediated transfer of substrate to CCT/TriC
GWAS		Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Childhood body mass index ( 33045005 ) Hip circumference adjusted for BMI ( 34021172 ) Menarche (age at onset) ( 25231870 27182965 ) Molar-incisor hypomineralization ( 23918034 ) Response to statin therapy ( 20339536 ) Risk-taking tendency (4-domain principal component model) ( 30643258 ) Smoking initiation ( 30617275 ) Smoking status (ever vs never smokers) ( 30643258 ) Triglycerides ( 30275531 )	Alzheimer's disease ( 28183528 ) Alzheimer's disease in APOE e4- carriers ( 25778476 ) Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Reaction time ( 29844566 )
Interacting Genes		5 interacting genes: FANCM HSPA13 NR1H2 PFDN1 UBE3A	55 interacting genes: ACTA1 ACTB ALB BRK1 CCDC85A CEBPA CEP126 CHGA DCTN1 DEFA1 DMAP1 EDRF1 EIF3C EIF4A2 EOMES ESS2 EXT2 EZH2 FAM20C GET3 GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 YEATS4 ZNF235
Entrez ID		80010	5201
HPRD ID		09867	05357
Ensembl ID		ENSG00000178966	ENSG00000113068
Uniprot IDs		Q9H9A7	O60925
PDB IDs		3MXN 3NBH 3NBI 4CGY 4CHT 4DAY 7XUV	6NR8 6NR9 6NRB 6NRC 6NRD 7WU7
GO Terms Enriched among Interactors		Regulation Of Protein Metabolic Process Protein Folding Chaperone Positive Regulation Of Post-translational Protein Modification Sperm Entry Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Protein Ubiquitination Positive Regulation Of Golgi Lumen Acidification Positive Regulation Of Secretion Of Lysosomal Enzymes Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Hormone-mediated Signaling Pathway Regulation Of Golgi Lumen Acidification Regulation Of High-density Lipoprotein Particle Assembly Protein Folding Prefoldin Complex Positive Regulation Of Protein Localization To Lysosome Regulation Of Protein Ubiquitination Positive Regulation Of Cellular PH Reduction Regulation Of Post-translational Protein Modification Intracellular Receptor Signaling Pathway Apolipoprotein A-I Receptor Binding Negative Regulation Of Type II Interferon-mediated Signaling Pathway Negative Regulation Of Pinocytosis Double-strand Break Repair Via Synthesis-dependent Strand Annealing Four-way Junction Helicase Activity FANCM-MHF Complex Positive Regulation Of Protein Monoubiquitination Regulation Of Protein Monoubiquitination Prostate Gland Growth Negative Regulation Of Cholesterol Storage Progesterone Receptor Signaling Pathway Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Digestive System Process Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Response To Type II Interferon Negative Regulation Of Macrophage Derived Foam Cell Differentiation 3'-5' DNA Helicase Activity Fanconi Anaemia Nuclear Complex Negative Regulation Of Amyloid Fibril Formation Phosphatidylcholine Acyl-chain Remodeling ATP Hydrolysis Activity Positive Regulation Of Protein Modification Process Regulation Of Proteolysis Nuclear Retinoid X Receptor Binding Resolution Of Meiotic Recombination Intermediates Four-way Junction DNA Binding Regulation Of Amyloid Fibril Formation Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Protein Localization Androgen Receptor Signaling Pathway	Positive Regulation Of Microtubule Nucleation Structural Constituent Of Cytoskeleton Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Microtubule Nucleation Nuclear Matrix Positive Regulation Of DNA Recombination NuA4 Histone Acetyltransferase Complex Regulation Of Cell Cycle Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of Double-strand Break Repair Intracellular Protein Localization Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Glutamate Receptor Binding Regulation Of Cellular Component Organization