RPP21 and RPP40

Number of citations: 37 (PubMedID 15096576)
Data Source: HPRD (in vitro)

		RPP21	RPP40
Name		ribonuclease P subunit p21	ribonuclease P/MRP subunit p40
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolar Ribonuclease P Complex Nucleolus Multimeric Ribonuclease P Complex Endoribonuclease Complex Ribonucleoprotein Complex	Ribonuclease MRP Complex Nucleus Nucleoplasm Nucleolar Ribonuclease P Complex Nucleolus Ribonuclease P Complex Multimeric Ribonuclease P Complex
	Molecular Function	RNA Binding Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding Metal Ion Binding	Ribonuclease MRP Activity RNA Binding Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding
	Biological Process	TRNA 5'-leader Removal RNA Processing TRNA Processing Response To Xenobiotic Stimulus	Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA 5'-leader Removal RRNA Processing TRNA Processing
Pathways		tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol	tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol
GWAS		Anxiety ( 33859377 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Cutaneous lupus erythematosus ( 25827949 ) Lung cancer ( 31577861 ) Moderate to vigorous physical activity levels ( 29899525 ) Neurociticism ( 29500382 ) Neuroticism ( 29255261 ) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848 ) Type 1 diabetes (age at diagnosis) ( 33179336 )	No GWAS studies recorded
Interacting Genes		3 interacting genes: RPP30 RPP38 RPP40	8 interacting genes: MEOX2 POP1 POP7 PTEN RPP14 RPP21 RPP30 RPP38
Entrez ID		79897	10799
HPRD ID		15275	09361
Ensembl ID		ENSG00000241370	ENSG00000124787
Uniprot IDs		A0A1U9X8H3 Q9H633	A0A087X1N3 O75818
PDB IDs		6AHR 6AHU	6AHR 6AHU 6AHV
GO Terms Enriched among Interactors		Nucleolar Ribonuclease P Complex Ribonuclease MRP Complex Ribonuclease P RNA Binding Multimeric Ribonuclease P Complex Ribonuclease P Activity TRNA 5'-leader Removal TRNA 5'-end Processing TRNA Processing TRNA Metabolic Process RRNA Processing RRNA Metabolic Process RNA Metabolic Process Nucleic Acid Metabolic Process Ribonuclease MRP Activity Nucleobase-containing Compound Metabolic Process RNA Processing Nucleolus Ribonuclease P Complex Interleukin-17A-mediated Signaling Pathway CD40 Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway CD40 Receptor Complex TRIF-dependent Toll-like Receptor Signaling Pathway Protein Kinase B Binding Interleukin-33-mediated Signaling Pathway T-helper 1 Type Immune Response Interleukin-17-mediated Signaling Pathway RNA Binding Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Positive Regulation Of JUN Kinase Activity Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Ubiquitin-ubiquitin Ligase Activity Bone Remodeling Endonucleolytic Cleavage Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Myeloid Dendritic Cell Differentiation Stimulatory C-type Lectin Receptor Signaling Pathway Protein Branched Polyubiquitination Cellular Response To Lectin Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Bone Resorption Positive Regulation Of T Cell Cytokine Production Regulation Of Receptor Localization To Synapse Interleukin-1-mediated Signaling Pathway Positive Regulation Of Osteoclast Differentiation Regulation Of Protein Localization To Synapse Endolysosomal Toll-like Receptor Signaling Pathway	Ribonuclease P RNA Binding Multimeric Ribonuclease P Complex Ribonuclease P Activity TRNA 5'-leader Removal TRNA 5'-end Processing Nucleolar Ribonuclease P Complex Ribonuclease MRP Complex TRNA Processing TRNA Metabolic Process RNA Processing Nucleolus Endoribonuclease Complex RNA Metabolic Process RNA Binding Nucleic Acid Metabolic Process RRNA Processing RRNA Metabolic Process Nucleoplasm Nucleobase-containing Compound Metabolic Process Nucleus Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Macromolecule Metabolic Process Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Ribonuclease P Complex Somite Specification Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Phosphatidylinositol Phosphate Phosphatase Activity Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Peptidyl-serine Phosphorylation Postsynaptic Density Assembly Neuron-neuron Synaptic Transmission Negative Regulation Of Cell Size Anaphase-promoting Complex Binding Forebrain Morphogenesis Presynaptic Membrane Assembly Presynaptic Membrane Organization Postsynaptic Specialization Assembly Schmidt-Lanterman Incisure Negative Regulation Of Excitatory Postsynaptic Potential TRNA Decay Locomotor Rhythm Cellular Response To Electrical Stimulus Ubiquitin Ligase Activator Activity