CAAP1 and XRCC4

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		CAAP1	XRCC4
Name		caspase activity and apoptosis inhibitor 1	X-ray repair cross complementing 4
Structure		No pdb structure
GO Annotations	Cellular Component	None	Condensed Chromosome Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Site Of Double-strand Break Nonhomologous End Joining Complex
	Molecular Function	None	DNA Binding Protein Binding Ligase Activity Enzyme Binding Identical Protein Binding FHA Domain Binding
	Biological Process	Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process	DNA Repair Base-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Response To X-ray Immunoglobulin V(D)J Recombination Positive Regulation Of Ligase Activity Cellular Response To Lithium Ion Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Protein Localization To Site Of Double-strand Break
Pathways		None	2-LTR circle formation SUMOylation of DNA damage response and repair proteins Nonhomologous End-Joining (NHEJ)
Drugs		None	S-(Dimethylarsenic)Cysteine
GWAS		Adverse response to drug ( 30420678 ) Attention function in attention deficit hyperactive disorder ( 26174813 ) Brain volume in infants (grey matter) ( 28763065 ) Loneliness ( 27629369 )	Clozapine-induced agranulocytosis ( 25187353 ) Diisocyanate-induced asthma ( 25918132 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Heel bone mineral density ( 30598549 ) Osteoarthritis biomarkers ( 25057126 ) Squamous cell lung carcinoma ( 28604730 ) Type 2 diabetes ( 25760438 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 ) White matter integrity (fractional anisotropy) ( 29752348 ) White matter integrity (mean diffusivity) ( 29752348 )
Interacting Genes		5 interacting genes: APP KAT7 OGT PTN XRCC4	23 interacting genes: ACTN1 AHNAK APLF APTX ASTE1 BIN1 CAAP1 CALM1 CHD3 CSNK2A1 GSC2 GZMB HAUS2 IFFO1 KRT27 LIG4 MAGEA6 NBN NHEJ1 OGT PNKP PRKDC VIM
Entrez ID		79886	7518
HPRD ID		12981	15951
Ensembl ID		ENSG00000120159	ENSG00000152422
Uniprot IDs		A0A3B3ISJ3 Q9H8G2	Q13426 Q7Z763
PDB IDs		Not available	1FU1 1IK9 3II6 3MUD 3Q4F 3RWR 3SR2 3W03 4XA4 5CHX 5CJ0 5CJ4 5E50 5WJ7 5WLZ 6ABO 7LSY 7LT3 7M3P 7NFC 7NFE 8BH3 8BHV 8BHY 8BOT 8EZA 8EZB
GO Terms Enriched among Interactors		Negative Regulation Of Long-term Synaptic Potentiation Molecular Function Activator Activity Response To Auditory Stimulus Histone Acetyltransferase Complex Positive Regulation Of Gene Expression, Epigenetic Regulation Of Cellular Component Organization Regulation Of Glycolytic Process Regulation Of Long-term Synaptic Potentiation Dendrite Development Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Response To Stress Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Developmental Process Regulation Of Cellular Response To Stress Regulation Of Stem Cell Population Maintenance FHA Domain Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Histone H3K23 Acetyltransferase Activity Histone H3K4 Acetyltransferase Activity Positive Regulation Of Leukocyte Chemotaxis Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Integrin Binding Positive Regulation Of Chemotaxis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Protein-containing Complex Learning Lipoprotein Particle Memory Regulation Of Protein Localization To Nucleus Positive Regulation Of Leukocyte Migration Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Heparin Binding Immune System Process Regulation Of Generation Of Precursor Metabolites And Energy Dendrite Regeneration	Double-strand Break Repair Via Nonhomologous End Joining Double-strand Break Repair DNA Repair DNA Metabolic Process DNA Damage Response DNA-dependent Protein Kinase-DNA Ligase 4 Complex Somatic Recombination Of Immunoglobulin Gene Segments Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Site Of Double-strand Break Protein Localization To Chromosome Somatic Cell DNA Recombination Single Strand Break Repair Somatic Diversification Of Immunoglobulins DNA Recombination Polynucleotide 3'-phosphatase Activity V(D)J Recombination DNA Ligase IV Complex Protein Localization To Site Of Double-strand Break Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Cellular Response To Stress Organelle Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Double-strand Break Repair Double-strand Break Repair Via Alternative Nonhomologous End Joining Nucleus Double-strand Break Repair Via Classical Nonhomologous End Joining Damaged DNA Binding Lymphoid Progenitor Cell Differentiation B Cell Activation Double-stranded RNA Binding Nucleic Acid Metabolic Process Protein Localization To Organelle Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Regulation Of DNA Repair Response To Stress Positive Regulation Of Double-strand Break Repair DNA Damage Checkpoint Signaling Telomere Maintenance Positive Regulation Of Chromosome Organization Sin3-type Complex PML Body Regulation Of DNA Metabolic Process DNA Endonuclease Activity Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response DNA Repair-dependent Chromatin Remodeling