ARHGEF5 and TRIM54

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid, two hybrid)

		ARHGEF5	TRIM54
Name		Rho guanine nucleotide exchange factor 5	tripartite motif containing 54
Structure		No pdb structure
GO Annotations	Cellular Component	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Projection Anchoring Junction Cell Periphery	Cytoplasm Cytoskeleton Microtubule Microtubule Associated Complex Z Disc
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Lipid Binding	Protein Binding Microtubule Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Myeloid Dendritic Cell Chemotaxis Actin Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of GTPase Activity Positive Regulation Of JUN Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Hematopoietic Stem Cell Homeostasis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Podosome Assembly Positive Regulation Of Protein Import	Microtubule-based Process Negative Regulation Of Microtubule Depolymerization Signal Transduction Cell Differentiation Innate Immune Response
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle	None
GWAS		Breast cancer ( 23535729 ) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226 ) Gut microbiota relative abundance (Parabacteroides) ( 33208821 ) Post bronchodilator FEV1/FVC ratio ( 26634245 )	Mean corpuscular hemoglobin ( 32888494 )
Interacting Genes		28 interacting genes: APP ATP13A1 CALCOCO2 CCNE1 CHPF COG6 EFHC2 EPM2AIP1 FKBP8 HSF2BP HSPBAP1 LMO2 LRATD1 MB21D2 MID2 NR4A1 PICK1 PLCG1 PLEKHG4 POLR1C RHOA SEPHS2 SLAIN1 TBC1D13 TCF4 TRIM27 TRIM54 ZRANB1	318 interacting genes: AAMDC ABHD17C ADCY4 AGFG1 AIRIM AK2 AK3 ANKRD11 ANKRD45 ARFIP2 ARHGAP29 ARHGEF5 ARHGEF6 ARMC7 ATXN3 ATXN3L ATXN7 BBX BMF BSCL2 BYSL C14orf39 C1orf216 C1orf35 C1QTNF2 C2orf49 C8orf74 CALM3 CARD9 CATSPERT CAVIN2 CBX8 CCDC102B CCDC146 CCDC17 CCDC187 CCDC26 CCDC28A CCDC87 CCHCR1 CCNC CDC37 CDK18 CDKAL1 CDKN1A CENPX CEP57L1 CEP68 CFAP100 CFAP206 CFAP53 CHCHD2 CHD2 CHD3 CKM CLPP CMIP CNGA3 CRADD CSNK2B CTNNA3 CWF19L2 CYTH4 DAXX DCAF8 DCLRE1B DCUN1D1 DDX6 DEUP1 DNAL4 DNASE1L1 DPYSL4 DRC4 DRG2 DTNB DTX2 DUSP16 DVL3 DYNC2I2 DYNLL1 EHHADH EIF4E2 ELMO1 ELOA ENKD1 EPHB2 EPM2AIP1 EXOC7 EXOC8 EXOSC5 EXTL2 FAM110A FAM124A FAM124B FAM161A FAM50B FAM90A1 FAM9A FARS2 FBF1 FBXO16 FBXW2 FLNC FMNL1 G2E3 GEM GIMAP2 GLP2R GMCL1 GNG13 GNL3L GTF2I GTF2IRD2 GTF2IRD2B HAUS1 HBG1 HDAC10 HGS HMMR HOXB5 HSF2 HSPB1 HYAL2 IL18RAP IL36A IL4I1 ING3 INPP5J IQUB ITGAE ITPKB JOSD1 KANK2 KAT14 KDM1A KIF9 KIFC3 KLHL38 KLHL42 KPNA2 KRT1 KRT3 KRT4 KRT6A KRT6B KRT6C KRT75 KRT76 KRT78 KRT79 KRT8 KRTAP11-1 KRTAP9-2 LENG1 LIN37 LINC00887 LMO1 LMO2 LMO3 LMO4 LNX1 LSM2 MAD2L2 MAOB MAPK3 MBD3 MCM7 MEAF6 MFAP1 MGARP MICAL2 MID2 MNS1 MRTFA MSH5 MYLK2 MYO15B MYO5B NEK6 NGLY1 NTAQ1 NUP54 NUP58 OFCC1 OSGIN1 OSTF1 OTUB1 OTUB2 PABPC3 PAIP2 PARVG PCDHGB1 PCDHGC3 PCSK7 PDZK1IP1 PICK1 PIK3R3 PIWIL1 PLEKHM1 PLK4 PPIG PPP1R18 PRF1 PRKAB2 PRKG1 PRMT5 PRPF18 PRR35 PSMA1 PYGM RAB35 RABGEF1 RAD23A RAPSN RASSF10 RBM15B RBM41 RCOR3 RELT RIMS3 RNF4 RSRC2 RUNX1T1 SCNM1 SDCBP SEC14L4 SELE SEMA4C SENP3 SH2D1B SHC3 SLC13A2 SLITRK3 SMARCD1 SMARCE1 SNF8 SOX14 SPG21 SPRING1 SSX2IP STAM STRC STXBP4 STYXL1 SYCE3 SYTL5 TBC1D22B TCAF1 TCAP TCEA2 TCEANC TCHP TEAD4 TEPSIN THAP4 THOC1 TJAP1 TLE6 TLR10 TMEM30A TNFAIP1 TNR TRIM55 TRIM63 TRIM69 TRIML2 TSG101 TSHZ3 TSPEAR TSSK3 TTC23 TTC9C TTN UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2I UBE2N UBE2U UBE2V2 UBL4A UCHL1 UCHL3 UCHL5 USHBP1 USP15 USP18 USP2 USP21 USP33 USP35 USP4 USP5 USP7 USP8 UTP14C VAMP4 VCAM1 VCP VPS28 VPS9D1 XAF1 YEATS4 YOD1 ZBTB16 ZFHX3 ZGPAT ZNF180 ZNF182 ZNF250 ZNF267 ZNF366 ZNF417 ZNF572 ZNF587 ZNF667-AS1
Entrez ID		7984	57159
HPRD ID		02932	05928
Ensembl ID		ENSG00000050327	ENSG00000138100
Uniprot IDs		Q12774	Q9BYV2
PDB IDs		Not available	3Q1D
GO Terms Enriched among Interactors		Regulation Of Supramolecular Fiber Organization Cytoplasm	Cysteine-type Deubiquitinase Activity Protein Binding Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity Keratin Filament Post-translational Protein Modification Ubiquitin Binding Cytosol Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Protein Modification Process Intermediate Filament-based Process Protein K48-linked Deubiquitination Keratinization Organelle Organization Cytoplasm Intermediate Filament Ubiquitin Conjugating Enzyme Activity Centrosome Positive Regulation Of Exosomal Secretion Deubiquitinase Activity Cytoskeleton Organization Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway K48-linked Deubiquitinase Activity Ubiquitin-dependent Protein Catabolic Process Membrane Fission Regulation Of Exosomal Secretion Modification-dependent Protein Catabolic Process Nucleoplasm Negative Regulation Of TORC1 Signaling Regulation Of DNA Repair Peptidase Activity Nucleus Proteolysis Microtubule-based Process Regulation Of DNA Metabolic Process Positive Regulation Of DNA Repair Regulation Of Cellular Response To Stress Proteolysis Involved In Protein Catabolic Process Protein K63-linked Deubiquitination Regulation Of Double-strand Break Repair Endosome Transport Via Multivesicular Body Sorting Pathway Regulation Of Extracellular Exosome Assembly DeNEDDylase Activity Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Cytoskeleton Microtubule-based Movement Endosome Organization