ST7 and MYOT

Number of citations: 0 (PubMedID 12809483)
Data Source: BioGRID (two hybrid)

		ST7	MYOT
Name		suppression of tumorigenicity 7	myotilin
Structure		No pdb structure
GO Annotations	Cellular Component	Membrane	Cytoplasm Cytoskeleton Plasma Membrane Actin Cytoskeleton Membrane Z Disc Axon Sarcolemma Neuronal Cell Body
	Molecular Function	Protein Binding	Actin Binding Protein Binding Axon Guidance Receptor Activity Structural Constituent Of Muscle Alpha-actinin Binding
	Biological Process	Extracellular Matrix Organization Regulation Of Cell Differentiation	Muscle Contraction Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Synapse Organization
Diseases		None	Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Limb-girdle muscular dystrophy (LGMD) Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Intraocular pressure ( 30591961 ) Response to alcohol consumption (flushing response) ( 29460428 ) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Atrial fibrillation ( 30061737 ) Heart rate ( 23583979 ) Severe malaria ( 29381699 ) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699 )
Interacting Genes		9 interacting genes: ACTN2 CUL4A CUL4B DCAF4 MYOT NFKBIA RACK1 SNAPIN ZFYVE9	17 interacting genes: ACTN1 ACTN2 ACTN3 APP AXIN1 DOCK9 FLNA FLNC GPRASP2 LRP12 NME7 PDLIM3 PFDN5 ST7 TFG TRIM55 TRIM63
Entrez ID		7982	9499
HPRD ID		09015	04981
Ensembl ID		ENSG00000004866	ENSG00000120729
Uniprot IDs		B7Z4L1 B7Z4U3 E7EPD9 E7EPW5 G3XAH9 H7BXS2 Q9NRC1 X5DRA0	A0A0C4DFM5 B4DT68 Q9UBF9
PDB IDs		Not available	2KDG 2KKQ
GO Terms Enriched among Interactors		Cul4-RING E3 Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Regulation Of Cellular Localization Positive Regulation Of Protein Catabolic Process Protein Ubiquitination Structural Constituent Of Muscle Regulation Of Intracellular Transport Protein Modification By Small Protein Conjugation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Actin Filament Uncapping Ubiquitin Protein Ligase Binding Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Late Endosome To Lysosome Transport Post-translational Protein Modification Titin Z Domain Binding Negative Regulation Of Transport Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To UV Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process IRE1-RACK1-PP2A Complex Negative Regulation Of Translational Frameshifting Phospholipase C-activating Angiotensin-activated Signaling Pathway I-kappaB/NF-kappaB Complex Positive Regulation Of Cell Cycle Phase Transition Cellular Response To Light Stimulus Ribosome Biogenesis Positive Regulation Of Mitotic Cell Cycle Microspike Assembly Z Disc Positive Regulation Of Intracellular Transport FATZ Binding Regulation Of Vesicle-mediated Transport Mitotic Cell Cycle Phase Transition Positive Regulation Of Catabolic Process Base-excision Repair, AP Site Formation Via Deaminated Base Removal Negative Regulation Of Translational Elongation Terminal Button Organization Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Response To UV Cell Cycle Phase Transition Cul4B-RING E3 Ubiquitin Ligase Complex Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Golgi To Plasma Membrane Protein Transport BH3 Domain Binding	Z Disc Integrin Binding Cytoskeletal Protein Binding Pseudopodium Actin Cytoskeleton Organization Actin Filament Binding Actin Binding Actin Filament Actin Filament-based Process Muscle Cell Development Focal Adhesion Assembly Actin Cytoskeleton Cell-substrate Junction Assembly Transmembrane Transporter Binding Cell-substrate Junction Organization Skeletal Muscle Atrophy Structural Constituent Of Muscle Cell Development Cortical Actin Cytoskeleton Cellular Component Assembly Regulation Of Glycolytic Process Skeletal Muscle Adaptation Striated Muscle Atrophy Sarcomere Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Platelet Alpha Granule Lumen Muscle Atrophy Regulation Of Carbohydrate Catabolic Process Focal Adhesion G Protein-coupled Receptor Binding Regulation Of ATP Metabolic Process Titin Binding Regulation Of Purine Nucleotide Metabolic Process Supramolecular Fiber Organization Identical Protein Binding Regulation Of Amyloid Fibril Formation Cytosol Negative Regulation Of Glycolytic Process Protein Serine/threonine Kinase Binding Organelle Organization Negative Regulation Of ATP Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Potassium Ion Transport Cytoplasm Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Wnt Signaling Pathway Sarcomere Organization Dendritic Shaft