HPS6 and TTC19

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		HPS6	TTC19
Name		HPS6 biogenesis of lysosomal organelles complex 2 subunit 3	tetratricopeptide repeat domain 19
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Endoplasmic Reticulum Cytosol Membrane BLOC-2 Complex Early Endosome Membrane	Mitochondrion Mitochondrial Inner Membrane Centrosome Membrane Midbody
	Molecular Function	Protein Binding GTP-dependent Protein Binding Small GTPase Binding	Protein Binding
	Biological Process	Lipid Metabolic Process Blood Coagulation Protein Secretion Lysosome Localization Pigmentation Lipid Homeostasis Platelet Dense Granule Organization Protein Localization To Membrane Melanosome Assembly	Mitotic Cytokinesis Mitochondrial Respiratory Chain Complex III Assembly Cell Division
Pathways		None	Complex III assembly
Diseases		Hermansky-Pudlak syndrome (HPS)	Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Household income (MTAG) ( 31844048 ) Intelligence (MTAG) ( 29326435 )	No GWAS studies recorded
Interacting Genes		11 interacting genes: CREB1 EP300 HPS5 MARK4 MNAT1 OSGEP PIK3CB PUM3 SUMO2 TTC19 UBC	44 interacting genes: AGXT APRT ATXN1 CCDC33 CHMP4A CIMIP1 COA6 CYSLTR2 DMRT3 EIF4ENIF1 FAM136A FAM217B FH FTO GORASP2 GPANK1 HOXD12 HPS6 IHO1 L3MBTL3 LDB2 MLN MXRA8 NAB2 NME4 POU6F2 PRR35 RBP1 REL RUSC1 RXFP3 SH2D4A SHISA6 SLC67A1-AS SMG9 SPRED1 TBX2 TCAP UBA1 UPF3B USP20 USP54 WASHC1 ZNF688
Entrez ID		79803	54902
HPRD ID		08471	07899
Ensembl ID		ENSG00000166189	ENSG00000011295
Uniprot IDs		Q86YV9	Q6DKK2
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Protein Tag Activity Nucleoplasm Chemotaxis To Arachidonate Transcription Coactivator Binding Tau Protein Binding Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Midbody Positive Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Transforming Growth Factor Beta3 Production Secretory Granule Organization Locomotion Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity BLOC-2 Complex TRNA N(6)-L-threonylcarbamoyladenine Synthase Activity	None