HHIPL2 and ALOX5

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid, two hybrid)

		HHIPL2	ALOX5
Name		HHIP like 2	arachidonate 5-lipoxygenase
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Extracellular Region Extracellular Space Nucleus Nuclear Envelope Nuclear Envelope Lumen Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Matrix Nuclear Membrane Secretory Granule Lumen Perinuclear Region Of Cytoplasm Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding	Arachidonate 5-lipoxygenase Activity Arachidonate 12(S)-lipoxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Hydrolase Activity Arachidonate 8(S)-lipoxygenase Activity Metal Ion Binding Dioxygenase Activity
	Biological Process	None	Long-chain Fatty Acid Metabolic Process Negative Regulation Of Endothelial Cell Proliferation Leukocyte Chemotaxis Involved In Inflammatory Response Leukocyte Migration Involved In Inflammatory Response Leukotriene Production Involved In Inflammatory Response Lipid Metabolic Process Icosanoid Metabolic Process Leukotriene Metabolic Process Response To Stress Inflammatory Response Humoral Immune Response Negative Regulation Of Angiogenesis Arachidonate Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Positive Regulation Of Bone Mineralization Lipid Oxidation Dendritic Cell Migration Glucose Homeostasis Long-chain Fatty Acid Biosynthetic Process Regulation Of Fat Cell Differentiation Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Regulation Of Insulin Secretion Negative Regulation Of Vascular Wound Healing Negative Regulation Of Wound Healing Regulation Of Inflammatory Response To Wounding Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cellular Response To Oxidative Stress Leukotriene A4 Biosynthetic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Lipoxin Biosynthetic Process
Pathways		None	Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Biosynthesis of Lipoxins (LX) Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Interleukin-18 signaling Biosynthesis of D-series resolvins Biosynthesis of maresins Biosynthesis of E-series 18(S)-resolvins Biosynthesis of aspirin-triggered D-series resolvins Biosynthesis of E-series 18(R)-resolvins Biosynthesis of DPAn-3-derived protectins and resolvins Biosynthesis of DPAn-3-derived maresins Biosynthesis of DPAn-3-derived 13-series resolvins Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
Drugs		None	Icosapent Vitamin E Masoprocol Aminosalicylic acid Mesalazine Montelukast Diethylcarbamazine Zileuton Sulfasalazine Meclofenamic acid Balsalazide Minocycline Hyperforin Resveratrol Licofelone MLN-977 Morniflumate Diacerein Fostamatinib Rhein alpha-Tocopherol succinate D-alpha-Tocopherol acetate
GWAS		Tonsillectomy ( 27182965 28928442 )	Alanine aminotransferase levels ( 33547301 ) Cholesterol, total ( 24097068 ) HDL cholesterol ( 24097068 ) HDL cholesterol levels ( 28334899 ) Immature fraction of reticulocytes ( 32888494 ) Mean corpuscular hemoglobin ( 20139978 32888494 ) Mean corpuscular volume ( 20139978 ) Total cholesterol levels ( 28334899 )
Interacting Genes		2 interacting genes: ALOX5 CFTR	27 interacting genes: ACTB ALOX5AP ALPL APP C10orf67 CCDC174 CEP57L1 CEP63 COTL1 DICER1 GATC GRB2 HHIPL2 HSD17B1 LCN1 LTC4S MAD1L1 MAPKAPK2 MEOX1 MEOX2 MTDH NUTM1 OOEP REL SYCE1 TBC1D7 TGFBRAP1
Entrez ID		79802	240
HPRD ID		08587	01065
Ensembl ID		ENSG00000143512	ENSG00000012779
Uniprot IDs		Q6UWX4	P09917
PDB IDs		Not available	3O8Y 3V92 3V98 3V99 6N2W 6NCF 7TTJ 7TTK 7TTL
GO Terms Enriched among Interactors		Regulation Of Hormone Secretion Regulation Of Insulin Secretion Leukotriene A4 Metabolic Process Regulation Of Protein Secretion Regulation Of Peptide Hormone Secretion Arachidonate Metabolite Production Involved In Inflammatory Response Leukotriene Production Involved In Inflammatory Response Leukotriene A4 Biosynthetic Process Arachidonate 5-lipoxygenase Activity Arachidonate 8(S)-lipoxygenase Activity Lipoxin Biosynthetic Process Arachidonate 12(S)-lipoxygenase Activity Positive Regulation Of Biomineral Tissue Development Small Molecule Metabolic Process Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Nitric-oxide Synthase Complex Nitrate Reductase Activity Oxidoreductase Activity, Acting On Other Nitrogenous Compounds As Donors Detoxification Of Nitrogen Compound Cellular Detoxification Of Nitrogen Compound Nitrate Metabolic Process Molybdenum Ion Binding Nitrite Reductase Activity Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Epoxide Metabolic Process Transepithelial Water Transport Molybdopterin Cofactor Binding Nitrite Reductase (NO-forming) Activity Positive Regulation Of Tooth Mineralization Negative Regulation Of Vascular Wound Healing Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Leukocyte Chemotaxis Involved In Inflammatory Response Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis Lipoxygenase Pathway ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Nuclear Envelope Lumen Regulation Of Protein Transport Small Molecule Biosynthetic Process	Leukotriene Metabolic Process Leukotriene-C4 Synthase Activity Somite Specification Embryonic Pattern Specification