CENPU and MLF1

Number of citations: 0 (PubMedID 15116101)
Data Source: HPRD (two hybrid, in vitro)

		CENPU	MLF1
Name		centromere protein U	myeloid leukemia factor 1
Structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Inner Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Centriolar Satellite	Nucleus Cytoplasm Cytoskeleton Cilium Ciliary Basal Body Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	DNA Binding Protein Binding Protein Domain Specific Binding
	Biological Process	Chromosome Segregation Chordate Embryonic Development	Myeloid Progenitor Cell Differentiation DNA-templated Transcription Regulation Of DNA-templated Transcription Cell Differentiation Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle G1/S Phase Transition
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	None
GWAS		No GWAS studies recorded	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143 ) Depression ( 29700475 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Major depressive disorder ( 27479909 ) PR interval ( 32439900 ) Sporadic neuroblastoma ( 28545128 ) Systolic blood pressure ( 30224653 )
Interacting Genes		20 interacting genes: CENPQ E2F6 EIF4G1 GIT1 LAMC1 MLF1 NDUFS2 NUP62 OGT PGRMC1 PLK1 PLK2 PLK3 PLXNB2 ROBO2 SPTBN4 TFIP11 TUBB2B UPF2 XRCC6	9 interacting genes: CENPU COP1 COPS3 DNAJB6 GRIK5 MAGEA11 MEOX2 NRBP1 YWHAZ
Entrez ID		79682	4291
HPRD ID		14722	03239
Ensembl ID		ENSG00000151725	ENSG00000178053
Uniprot IDs		Q71F23	A0A0S2Z4A4 A0A0S2Z4U8 A0A140VKD2 A0A494C175 A0A499FJ64 B2RD48 C9JNE5 C9K0D4 P58340 Q2TLE4
PDB IDs		7PB8 7PKN 7QOO 7R5S 7R5V 7XHN 7XHO 7YWX 7YYH 8K4D	3UAL 3UBW 6Y8E
GO Terms Enriched among Interactors		Regulation Of Cellular Component Organization Spindle Pole Regulation Of Cytokinesis Positive Regulation Of Protein Localization Regulation Of Cell Cycle Process Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Protein Localization To Cell Periphery Regulation Of Cell Division Regulation Of Protein Localization Centrosome Separation Regulation Of Protein-containing Complex Assembly Cytoskeleton Regulation Of Cell Cycle Negative Regulation Of Cellular Component Organization Negative Regulation Of Synapse Organization Cell Junction Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Mitotic Spindle Organization Synapse Organization Organelle Organization Regulation Of Microtubule-based Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Translation In Response To Stress Regulation Of Synapse Organization Regulation Of Centriole Replication Negative Regulation Of Macromolecule Biosynthetic Process Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Telomeric DNA Binding Negative Regulation Of Protein-containing Complex Assembly Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Spindle Organization Regulation Of Protein Catabolic Process Centrosome Cell Cycle Phase Transition Kinetochore Regulation Of Synapse Assembly Negative Regulation Of Catabolic Process Positive Regulation Of Translation Regulation Of Microtubule Cytoskeleton Organization Mitotic Spindle Pole Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Chaperone-mediated Autophagy Regulation Of Protein Metabolic Process Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly	None