BEND5 and VPS25

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		BEND5	VPS25
Name		BEN domain containing 5	vacuolar protein sorting 25 homolog
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus	ESCRT II Complex Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Endosome Membrane Membrane Extracellular Exosome
	Molecular Function	DNA Binding Protein Binding	Structural Molecule Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of DNA-templated Transcription	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Membrane Fission
Pathways		None	Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		31 interacting genes: APP BUD31 CFTR CTNNBIP1 DDR1 EIF3D ERBB3 FAM161A FXR1 GFI1B GORASP2 GRAP2 HOXA1 LCE1B LMO3 NTAQ1 PIMREG PRKAB2 PTGR2 RTP5 SMARCD1 TSC1 TSPOAP1 UBE2I USP2 USP20 USP7 VPS25 ZGPAT ZNF417 ZNF688	24 interacting genes: APIP ASPG B9D2 BEND5 BPIFA1 CHMP6 CRLF3 EIF4G3 GPR35 LTB4R2 PICK1 REL RHOXF2 SDCBP2 SEPTIN14 SNCA SNF8 SPG21 SPRY2 SYCE1 TADA2A TRIM27 UBC VPS36
Entrez ID		79656	84313
HPRD ID		07756	14396
Ensembl ID		ENSG00000162373	ENSG00000131475
Uniprot IDs		A0A0S2Z5N0 Q7L4P6	Q9BRG1
PDB IDs		Not available	2ZME 3CUQ 3HTU
GO Terms Enriched among Interactors		Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Long-term Synaptic Potentiation Cysteine-type Endopeptidase Activity Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Signaling Receptor Activity	Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization ESCRT II Complex Multivesicular Body Assembly Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Lipid Binding Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosome Organization Regulation Of Exosomal Secretion Negative Regulation Of Autophagy Endosomal Transport