FAM184A and VPS52

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		FAM184A	VPS52
Name		family with sequence similarity 184 member A	VPS52 subunit of GARP complex
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Extracellular Space Cytoplasm Cytosol Cytoskeleton Centriolar Satellite Ciliary Basal Body	GARP Complex Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Presynapse Postsynapse EARP Complex
	Molecular Function	Protein Binding	Protein Binding Syntaxin Binding
	Biological Process	None	Protein Targeting Golgi To Vacuole Transport Lysosomal Transport Ectodermal Cell Differentiation Protein Transport Endocytic Recycling Retrograde Transport, Endosome To Golgi Embryonic Ectodermal Digestive Tract Development Vesicle-mediated Cholesterol Transport
Pathways		None	Retrograde transport at the Trans-Golgi-Network
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678 ) Parkinson's disease progression (composite) ( 33111402 ) Parkinson's disease progression (motor) ( 33111402 ) Schizophrenia ( 30285260 )	Autism spectrum disorder or schizophrenia ( 28540026 ) Body mass index ( 26426971 )
Interacting Genes		11 interacting genes: AMOTL2 APP BRAP BRCA1 GOLGA2 LRRK1 LRRK2 MAP3K1 MTDH PPP1R13B VPS52	101 interacting genes: AAMP AIRIM ARNT2 ATP6V1D BYSL C1orf216 CABP5 CACNA1A CATSPERT CCDC102B CCDC13 CCDC146 CCDC185 CCDC187 CCDC33 CCDC57 CCHCR1 CDC20B CDC5L CDK18 CEP19 CFAP206 CWF19L2 DCX DDX6 DNAJC11 DTNB EPM2AIP1 FAM110A FAM161A FAM161B FAM184A FAM50B GEM GFM2 GOLGA1 GORASP2 GPKOW HAUS1 HDAC4 HEATR1 HGS HOXB5 JAKMIP2 KANK2 KIAA1217 KIF5B KIF9 KIFC3 KLC3 KLHL42 LMO4 LNX1 MAGEL2 MAPK3 METTL13 MFAP1 MRPL1 MRPL11 NDC80 NFKBIB NOP2 NR2C2AP OTUD6A PIMREG PKN3 PPP1R18 PRKAA1 PRKAA2 RAB4A RAB4B RABEP2 RUNX1T1 SCNM1 SH2D4A SMARCE1 STX11 TAB2 TBC1D1 TBC1D22B TCEANC TCP11L1 TEAD4 THAP11 TPM3 TRAF4 TRAF6 TSSK3 TSTD2 TXLNB TXN2 USP2 VEZF1 VPS28 VPS53 WASHC3 WTAP ZC2HC1C ZMAT2 ZNF417 ZNF587
Entrez ID		79632	6293
HPRD ID		09856	09142
Ensembl ID		ENSG00000111879	ENSG00000223501
Uniprot IDs		H7BY63 Q6P9G8 Q8NB25	A0A1U9X8S4 B3KMF7 B4DS44 Q4VXZ2 Q8N1B4
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Intracellular Signal Transduction Cellular Response To Manganese Ion Golgi-associated Vesicle Recycling Endosome Regulation Of Reactive Oxygen Species Metabolic Process Cellular Response To Catecholamine Stimulus Signal Transduction Response To Catecholamine Response To Manganese Ion MAP Kinase Kinase Kinase Activity Amyloid-beta Complex Regulation Of Canonical Wnt Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Postsynapse Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Cytoplasm Modulation Of Excitatory Postsynaptic Potential Identical Protein Binding Centrosome Cycle Syntaxin Binding MAPK Cascade Embryonic Ectodermal Digestive Tract Development Nuclear Membrane Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Tubulin Binding Myeloid Cell Development Acetylcholine Receptor Activator Activity Regulation Of Wnt Signaling Pathway Endosome Cell Surface Receptor Signaling Pathway Lipoprotein Particle Positive Regulation Of Protein Import Histone H2AK127 Ubiquitin Ligase Activity P53 Binding Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding PTB Domain Binding	Protein Binding Cytoskeleton Organelle Assembly Centrosome Microtubule Binding Microtubule-based Process Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Organelle Organization Organelle Disassembly Ciliary Basal Body Kinesin Complex Protein Localization To Lipid Droplet Protein Localization To Vacuole Microtubule Cytoskeleton Organization Protein Localization To Lysosome Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Insulin-responsive Compartment Centriole