MAPKAP1 and ECI1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		MAPKAP1	ECI1
Name		MAPK associated protein 1	enoyl-CoA delta isomerase 1
Structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Cilium Membrane Early Endosome Membrane Late Endosome Membrane TORC2 Complex Perinuclear Region Of Cytoplasm Serine/threonine Protein Kinase Complex	Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Kinase Binding Small GTPase Binding Phosphatidylinositol-3,4-bisphosphate Binding Molecular Adaptor Activity Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding Enzyme-substrate Adaptor Activity	Catalytic Activity Delta(3)-delta(2)-enoyl-CoA Isomerase Activity Isomerase Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cytoskeleton Organization Insulin Receptor Signaling Pathway Substantia Nigra Development Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels Cellular Response To Insulin Stimulus TORC2 Signaling Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Insulin Receptor Signaling Pathway Protein Stabilization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cellular Response To Oxidative Stress	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation
Pathways		PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Mitochondrial protein degradation
Drugs		None	Octanoyl-Coenzyme A Benzamidine
GWAS		Body mass index ( 28892062 ) Diverticular disease ( 30177863 ) Fish- and plant-related diet ( 32066663 ) Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae) ( 33208821 ) Itch intensity from mosquito bite ( 28199695 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Medication use (calcium channel blockers) ( 31015401 ) Raw vegetable consumption ( 32066663 ) Resting heart rate ( 27798624 ) Sleep duration ( 30531941 ) Smoking status (ever vs never smokers) ( 30643258 )	Anthropometric traits (multi-trait analysis) ( 30166351 ) Serum alkaline phosphatase levels ( 33547301 )
Interacting Genes		12 interacting genes: ABCB1 AKT1 CDC42EP1 ECI1 MAPK8 MLST8 MTOR NRAS PRKCA SGK1 UBC YWHAG	3 interacting genes: APP MAPKAP1 POT1
Entrez ID		79109	1632
HPRD ID		17464	02628
Ensembl ID		ENSG00000119487	ENSG00000167969
Uniprot IDs		Q9BPZ7	A0A384NKJ3 P42126
PDB IDs		3VOQ 5ZCS 6ZWM 6ZWO 7LC1 7LC2 7PE7 7PE8 7PE9 7TZO 7VV8 7VV9 7VVB 7VVG	1SG4
GO Terms Enriched among Interactors		Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation TORC1 Signaling TOR Signaling Intracellular Signal Transduction Positive Regulation Of TOR Signaling Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Nutrient Levels Positive Regulation Of Cellular Component Biogenesis Intracellular Signaling Cassette Cellular Response To Nutrient Levels Response To Peptide Hormone Response To Hormone Cellular Response To Hormone Stimulus Protein Serine Kinase Activity Regulation Of TOR Signaling Positive Regulation Of Pentose-phosphate Shunt Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein Serine/threonine Kinase Activity Cellular Response To Osmotic Stress Positive Regulation Of Actin Filament Polymerization Regulation Of Biological Quality Negative Regulation Of Translation Cellular Response To Starvation TORC1 Complex Regulation Of Pentose-phosphate Shunt SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein-containing Complex Assembly Cellular Response To Oxygen-containing Compound Negative Regulation Of TORC1 Signaling Response To Ketone Positive Regulation Of TORC1 Signaling Response To Starvation Regulation Of NADP Metabolic Process Protein Kinase Activity Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Response To Osmotic Stress TORC2 Complex Response To Alcohol Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Polymerization Cellular Response To Chemical Stress Cellular Response To Stress Anoikis Negative Regulation Of TOR Signaling Post-transcriptional Regulation Of Gene Expression Mitochondrion Positive Regulation Of Endothelial Cell Proliferation Regulation Of TORC2 Signaling	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Early Endosome Membrane Amylin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Regulation Of Cellular Response To Stress Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Telomeric Loop Disassembly 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Telomeric D-loop Binding Telomere Assembly Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Single-stranded Telomeric DNA Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Early Endosome Regulation Of Toll Signaling Pathway Shelterin Complex Axon Choice Point Recognition Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Heparan Sulfate Binding