BBLN and FGD4

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		BBLN	FGD4
Name		bublin coiled coil protein	FYVE, RhoGEF and PH domain containing 4
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Kinetochore Microtubule Cytoskeleton Intermediate Filament Cell Junction Anchoring Junction Subapical Part Of Cell	Ruffle Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Lamellipodium Filopodium Cell Projection
	Molecular Function	Protein Binding Molecular Adaptor Activity	Actin Binding Guanyl-nucleotide Exchange Factor Activity Zinc Ion Binding Small GTPase Binding Metal Ion Binding
	Biological Process	Apoptotic Process Gene Expression Osteoclast Differentiation Intermediate Filament Bundle Assembly Bone Resorption Bone Development Multinuclear Osteoclast Differentiation Apoptotic Signaling Pathway	Cytoskeleton Organization Regulation Of Cell Shape Actin Cytoskeleton Organization Regulation Of GTPase Activity Filopodium Assembly Regulation Of Small GTPase Mediated Signal Transduction
Pathways		None	NRAGE signals death through JNK G alpha (12/13) signalling events CDC42 GTPase cycle
Diseases		None	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		No GWAS studies recorded	Figural/spatial cognitive ability ( 31620175 ) Health literacy ( 31250787 ) Mean platelet volume ( 27863252 32888494 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552 )
Novel Interactors		2 novel interactors: CIZ1 GOLGA2	None recorded
Interacting Genes		7 interacting genes: ATP6V1E2 CEP290 FGD4 IKBIP INPP1 KRT20 THAP11	3 interacting genes: ACTA1 BBLN CDC42
Entrez ID		79095	121512
HPRD ID		12946	16891
Ensembl ID		ENSG00000171159	ENSG00000139132
Uniprot IDs		Q9BUW7	B7Z493 B7Z8F9 E9PJX4 E9PQT1 F8VWL3 F8W1R0 Q49A55 Q96M96
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		None	Supramolecular Fiber Organization Filopodium Cytoskeleton Actin Filament Organization Apolipoprotein A-I Receptor Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Neuropilin Signaling Pathway GBD Domain Binding Storage Vacuole Myeloid Cell Differentiation Myeloid Leukocyte Differentiation Subapical Part Of Cell Multinuclear Osteoclast Differentiation Striated Muscle Thin Filament Skeletal Muscle Thin Filament Assembly Mesenchyme Migration Leading Edge Membrane Leukocyte Differentiation Thioesterase Binding Positive Regulation Of Pinocytosis Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Golgi Transport Complex Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Intermediate Filament Bundle Assembly Endothelin Receptor Signaling Pathway Positive Regulation Of Pseudopodium Assembly Golgi Localization Cardiac Conduction System Development Establishment Of Epithelial Cell Apical/basal Polarity Cell Migration Involved In Heart Development Dendritic Spine Morphogenesis Regulation Of Attachment Of Spindle Microtubules To Kinetochore Establishment Of Apical/basal Cell Polarity Dendritic Cell Migration Establishment Of Monopolar Cell Polarity GTP-dependent Protein Binding Heart Contraction Embryonic Heart Tube Development Filopodium Assembly Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Kinetochore Microtubule Myosin Binding Bone Resorption Cellular Developmental Process Positive Regulation Of Lamellipodium Assembly