DDX54 and SEMA4A

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		DDX54	SEMA4A
Name		DEAD-box helicase 54	semaphorin 4A
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Golgi Apparatus Membrane	Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Nucleic Acid Binding Transcription Corepressor Activity RNA Binding RNA Helicase Activity Helicase Activity Signaling Receptor Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Nuclear Estrogen Receptor Binding	Protein Binding Semaphorin Receptor Binding Neuropilin Binding Chemorepellent Activity
	Biological Process	RRNA Processing RNA Processing RNA Metabolic Process Estrogen Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription	Angiogenesis Neural Crest Cell Migration Adaptive Immune Response T Cell Differentiation Involved In Immune Response Immune System Process Nervous System Development Axonogenesis Axon Guidance Regulation Of Cell Shape Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Cell Differentiation Positive Regulation Of Cell Migration T-helper 1 Cell Differentiation Negative Chemotaxis Semaphorin-plexin Signaling Pathway Positive Regulation Of Excitatory Synapse Assembly Positive Regulation Of Inhibitory Synapse Assembly
Pathways		None	Other semaphorin interactions
Diseases		None	Retinitis pigmentosa (RP) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Body mass index ( 26426971 ) Response to fenofibrate (adiponectin levels) ( 23149075 )	Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Platelet count ( 32888494 ) Systolic blood pressure ( 30224653 )
Interacting Genes		21 interacting genes: APP CASK CSNK2A1 DVL3 DYNLT1 ESR1 ESR2 NEDD4 NEDD4L NR3C1 PGR PJA1 POLR2G PTPRD RNF10 SEMA4A SMURF1 TMED9 USP7 YWHAE ZNF394	3 interacting genes: DDX54 HAVCR1 PLXND1
Entrez ID		79039	64218
HPRD ID		13129	09528
Ensembl ID		ENSG00000123064	ENSG00000196189
Uniprot IDs		Q8TDD1	B4DKS5 Q9H3S1
PDB IDs		8FKT 8FKU 8FKV 8FKW 8FKX 8FKY	Not available
GO Terms Enriched among Interactors		Estrogen Response Element Binding Steroid Binding Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Nuclear Receptor Activity Hormone-mediated Signaling Pathway Receptor Catabolic Process Nuclear Steroid Receptor Activity Positive Regulation Of Catabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Metabolic Process Protein Ubiquitination Enzyme Binding Nuclear Estrogen Receptor Activity Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Cell Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Toll-like Receptor Signaling Pathway Nuclear Receptor-mediated Corticosteroid Signaling Pathway Intracellular Signal Transduction Macromolecule Catabolic Process Phosphoserine Residue Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Synapse Organization Receptor Metabolic Process Regulation Of RNA Metabolic Process Protein Targeting To Vacuole Sodium Channel Inhibitor Activity Post-translational Protein Modification Protein Monoubiquitination Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Component Organization Regulation Of Anatomical Structure Morphogenesis Regulation Of Metal Ion Transport Regulation Of Primary Metabolic Process Ubiquitin Protein Ligase Activity Establishment Of Protein Localization To Vacuole Regulation Of Dendrite Morphogenesis Signal Transduction Potassium Channel Inhibitor Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Catabolic Process Protein Catabolic Process Regulation Of Potassium Ion Transmembrane Transport Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process	None