KCNAB1 and SRPK1

Number of citations: 0 (PubMedID 23602568)
Data Source: BioGRID (enzymatic study)

		KCNAB1	SRPK1
Name		potassium voltage-gated channel subfamily A regulatory beta subunit 1	SRSF protein kinase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Cytoplasmic Side Of Plasma Membrane Membrane Potassium Channel Complex Juxtaparanode Region Of Axon	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Nuclear Matrix Nuclear Speck
	Molecular Function	Carbonyl Reductase (NADPH) Activity Voltage-gated Potassium Channel Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Potassium Channel Regulator Activity Oxidoreductase Activity Protein Domain Specific Binding Transmembrane Transporter Binding NADPH Binding Molecular Function Inhibitor Activity	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Learning Or Memory Transmembrane Transport Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Voltage-gated Potassium Channel Activity	Spliceosomal Complex Assembly MRNA Processing Protein Phosphorylation Chromosome Segregation RNA Splicing Cell Differentiation Sperm DNA Condensation Intracellular Signal Transduction Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing
Pathways		Voltage gated Potassium channels	Maturation of nucleoprotein Replacement of protamines by nucleosomes in the male pronucleus
Drugs		Enflurane Promethazine Miconazole	None
GWAS		Age-related nuclear cataracts ( 24951543 ) Aging traits ( 17903295 ) Bevacizumab-induced hypertension ( 34616010 ) Coronary artery disease ( 26708285 ) Focal epilepsy (with hippocampal sclerosis) ( 30531953 ) Offspring birth weight ( 31043758 )	Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 )
Interacting Genes		9 interacting genes: APP DLG1 FBXO7 KCNA2 NEDD4 NEDD4L SLC39A1 SLC39A2 SRPK1	167 interacting genes: ADPRH AHCYL1 ALKBH3 AMMECR1L APEX1 APP ARGLU1 ARHGAP12 ARHGAP26 ARK2N ASAH1 ASXL1 AURKA AURKC C11orf52 C11orf87 C16orf78 C9orf72 CACNB1 CAMK2D CBX5 CDC42EP3 CDK7 CDKL3 CHEK2 CHERP CHUK CIAO1 CIMAP1D CLIC5 CLK1 CLK4 CRHR1 CSAG1 DAW1 DDX47 DHX8 DHX9 DNAJC8 DUSP6 ECM1 EIF3M EPB41L4A EPHA3 ERBB2 ESRRG FAM124A FAM76B FERMT1 FGF12 FHL1 FKBP3 FLOT1 FLT1 GABARAP GABARAPL1 HBS1L HIRIP3 HMGN3 HNRNPA1 IFIT5 IKBKG JHY KCNAB1 KCNN2 KPNA2 KPTN KRR1 LAMC1 LARP1 LBR LCE3D LIMK1 LINC00312 LUC7L3 MACROH2A1 MAGEB1 MAOB MAP1LC3A MAPK12 MAPK14 MAPKAPK5 MAPT MBNL3 MBP MRPL43 MRPS11 NCK2 NELFE NKAP NOL4L NOP16 NOVA1 NSMCE4A NSRP1 NUDT21 NXT2 OCEL1 OR6B3 PAK4 PDGFRA PDPK1 PELI1 PELI2 PEX19 PFN1 PHF7 POLR2E PPIA PPIL1 PRM1 PRPF38A PTK2 RBM23 RBMS2 RIMS4 RPS6KB2 RSRC1 RSRC2 RSRP1 SAFB SANBR SCAF11 SEC23B SERPINB10 SETD3 SFMBT1 SLAIN2 SLC4A1AP SNRNP70 SPANXN4 SPATS2 SREK1 SRRM1 SRSF1 SRSF10 SRSF12 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 STAU1 STK26 SUDS3 TAF1B TFEB TNFRSF10C TOP2A TRA2B TRIM65 U2AF1 U2AF2 UBD UBE2E2 USP7 VANGL1 VDR WDR55 YPEL2 YTHDC1 YWHAG ZMYND11 ZNF444 ZNF514 ZRANB2
Entrez ID		7881	6732
HPRD ID		03089	15992
Ensembl ID		ENSG00000169282	ENSG00000096063
Uniprot IDs		B7Z435 B7Z8E5 F8W6W4 Q14722 Q5MJQ3	Q96SB4
PDB IDs		Not available	1WAK 1WBP 3BEG 4WUA 5MXX 5MY8 5NNG 5XV7 6FAD 7DD1 7PQS 7ZKS
GO Terms Enriched among Interactors		Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Membrane Potential Regulation Of Monoatomic Cation Transmembrane Transport Synapse Organization Regulation Of Sodium Ion Transport Regulation Of Potassium Ion Transmembrane Transport Metal Ion Transport Sodium Channel Inhibitor Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Transport Potassium Channel Inhibitor Activity Developmental Process Monoatomic Cation Transport Regulation Of Metal Ion Transport Negative Regulation Of Sodium Ion Transport Regulation Of Monoatomic Ion Transport Transmembrane Transporter Binding Monoatomic Ion Transport Receptor Catabolic Process Metal Ion Transmembrane Transporter Activity Cell Junction Organization Negative Regulation Of Potassium Ion Transmembrane Transport Zinc Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transport Zinc Ion Transport Ionotropic Glutamate Receptor Binding Negative Regulation Of Potassium Ion Transport Positive Regulation Of Catabolic Process Leukocyte Activation Positive Regulation Of Protein Catabolic Process Plasma Membrane Neuromuscular Junction Development Regulation Of Sodium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Regulation Of Plasma Membrane Bounded Cell Projection Organization Cell Activation Regulation Of Cell Projection Organization Ubiquitin-protein Transferase Activity Receptor Metabolic Process Inorganic Ion Transmembrane Transport Protein Polyubiquitination Protein Monoubiquitination Monoatomic Ion Transmembrane Transport Amyloid-beta Complex Growth Cone Lamellipodium Synaptic Membrane Regulation Of Synapse Organization Regulation Of Response To Calcium Ion	RNA Splicing Regulation Of MRNA Processing MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome RNA Binding Regulation Of RNA Splicing MRNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process RNA Processing RNA Splicing, Via Transesterification Reactions Nucleoplasm Nucleus MRNA Binding Nuclear Speck Nucleic Acid Metabolic Process RNA Metabolic Process MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Nucleic Acid Binding Protein Kinase Activity Negative Regulation Of MRNA Metabolic Process MRNA Splice Site Recognition Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome RS Domain Binding Kinase Activity Negative Regulation Of RNA Splicing Spliceosomal Complex Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Gene Expression Protein-RNA Complex Assembly Pre-mRNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Alternative MRNA Splicing, Via Spliceosome Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific MRNA Binding Main Axon Response To Starvation Regulation Of Toll Signaling Pathway Catalytic Step 2 Spliceosome Protein Autophosphorylation IkappaB Kinase Complex Positive Regulation Of Viral Process Protein Phosphorylation Positive Regulation Of RNA Splicing