FZD5 and UBTD1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		FZD5	UBTD1
Name		frizzled class receptor 5	ubiquitin domain containing 1
Structure			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Early Endosome Golgi Apparatus Plasma Membrane Bicellular Tight Junction Cell Surface Membrane Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane Cell Projection Perikaryon Synapse Perinuclear Region Of Cytoplasm	None
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding Lipid Binding Wnt-protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Wnt Receptor Activity Protein-containing Complex Binding	Protein Binding
	Biological Process	Embryonic Axis Specification Angiogenesis Eye Development Vasculature Development Glandular Epithelial Cell Maturation Positive Regulation Of T Cell Cytokine Production Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Synapse Assembly Negative Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification, Embryo Wnt Signaling Pathway Neuron Differentiation Embryonic Camera-type Eye Development Post-embryonic Camera-type Eye Development Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Embryonic Camera-type Eye Morphogenesis System Development Spemann Organizer Formation Canonical Wnt Signaling Pathway Apoptotic Process Involved In Morphogenesis Intestinal Epithelial Cell Maturation Branching Involved In Labyrinthine Layer Morphogenesis Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Labyrinthine Layer Blood Vessel Development Chorionic Trophoblast Cell Differentiation Cellular Response To Molecule Of Bacterial Origin Regulation Of Chorionic Trophoblast Cell Proliferation Regulation Of Mitophagy Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Bicellular Tight Junction Assembly	None
Pathways		Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway Asymmetric localization of PCP proteins Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Signaling by RNF43 mutants	None
GWAS		Hematocrit ( 32888494 ) Hemoglobin ( 32888494 )	Obesity-related traits ( 23251661 ) Post bronchodilator FEV1/FVC ratio ( 26634245 )
Interacting Genes		13 interacting genes: ABI3BP GOPC GSK3B LRP6 LZTFL1 RGS2 ROR2 RPS6KA6 SLC22A2 SLC35B1 UBTD1 WNT5A WNT7A	20 interacting genes: BCOR BRD10 CD1A FZD5 MID1 MID2 MRFAP1 MRFAP1L1 PFKM RANBP2 RNF10 RNF5 TEAD1 TP53BP2 TRAF6 TRIM39 TRIM50 UBE2D1 UBE2D4 WWP2
Entrez ID		7855	80019
HPRD ID		03427	08568
Ensembl ID		ENSG00000163251	ENSG00000165886
Uniprot IDs		Q13467	Q9HAC8
PDB IDs		5URY 5URZ 6O39 6WW2	Not available
GO Terms Enriched among Interactors		Canonical Wnt Signaling Pathway Postsynapse Assembly Wnt Signaling Pathway Frizzled Binding Positive Regulation Of Protein Localization To Synapse Toxin Transmembrane Transporter Activity Regulation Of Neuron Projection Development Wnt Signalosome Regulation Of Protein Localization To Cilium Epithelial To Mesenchymal Transition Midbrain Dopaminergic Neuron Differentiation Excitatory Synapse Assembly Secondary Palate Development Presynapse Assembly Establishment Of Cell Polarity Negative Regulation Of Developmental Process Mesenchymal Cell Differentiation Presynapse Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of MAPK Cascade Regulation Of Cell Projection Organization Uterus Development Positive Regulation Of Cell Projection Organization Central Nervous System Neuron Differentiation Regulation Of Axonogenesis Regulation Of JNK Cascade Regulation Of Protein Localization To Synapse Wnt-protein Binding Positive Regulation Of Neuron Projection Development Establishment Or Maintenance Of Cell Polarity Embryonic Axis Specification Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Lipid Midbrain Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Dopaminergic Neuron Differentiation Cellular Response To Lipid Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Epithelial Cell Proliferation Neuron Projection Organization Regulation Of Protein Localization Postsynapse Organization Presynapse Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Protein Localization Regulation Of Microtubule Anchoring At Centrosome Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Receptor Tyrosine Kinase-like Orphan Receptor Binding Chemoattraction Of Serotonergic Neuron Axon	Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Transferase Activity Post-translational Protein Modification Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Modification Process Positive Regulation Of T Cell Mediated Immunity Identical Protein Binding Protein Autoubiquitination Protein Localization To Microtubule Regulation Of T Cell Mediated Immunity Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Positive Regulation Of T Cell Cytokine Production Ubiquitin Conjugating Enzyme Activity Zinc Ion Binding Phosphoprotein Binding Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of T Cell Cytokine Production Phosphofructokinase Activity Glycolysis From Storage Polysaccharide Through Glucose-1-phosphate Negative Regulation Of Tooth Mineralization BCOR Complex Antigen Processing And Presentation Of Exogenous Antigen Regulation Of Lymphocyte Mediated Immunity Protein Localization To Cytoskeleton Toll-like Receptor Signaling Pathway Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Adaptive Immune Response Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Proteasomal Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Cytoplasmic Periphery Of The Nuclear Pore Complex