PRDM2 and E2F1

Number of citations: 32 (PubMedID 9223517)
Data Source: BioGRID (pull down)

		PRDM2	E2F1
Name		PR/SET domain 2	E2F transcription factor 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus	Nuclear Chromosome Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Centrosome Protein-containing Complex Rb-E2F Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Sequence-specific DNA Binding Metal Ion Binding Histone H3K9 Trimethyltransferase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Sequence-specific DNA Binding Protein Dimerization Activity Molecular Adaptor Activity DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Determination Of Adult Lifespan Methylation Positive Regulation Of Transcription By RNA Polymerase II	DNA Damage Checkpoint Signaling Negative Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Gene Expression Forebrain Development Response To Lipopolysaccharide Positive Regulation Of Apoptotic Process Anoikis Negative Regulation Of DNA Binding Negative Regulation Of Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation MRNA Stabilization Regulation Of Cell Cycle Positive Regulation Of Glial Cell Proliferation Negative Regulation Of Fat Cell Proliferation Cellular Response To Fatty Acid Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Lens Fiber Cell Apoptotic Process Cellular Response To Nerve Growth Factor Stimulus Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		None	Activation of NOXA and translocation to mitochondria Inhibition of replication initiation of damaged DNA by RB1/E2F1 Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Activation of PUMA and translocation to mitochondria Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest G2 Phase Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by E2F6 Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
GWAS		Anti-drug antibodies in autoimmune disease (time to event) ( 33125391 ) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872 ) Chronotype ( 30696823 ) Copper levels ( 26025379 ) HDL cholesterol levels in HIV infection ( 33109212 ) Intracranial aneurysm ( 30823506 ) Left ventricular function change in anthracycline treatment ( 28542097 ) Logical memory (delayed recall) in Alzheimer's disease dementia ( 29274321 ) Parkinson's disease ( 26227905 ) Polycystic ovary syndrome (reproductive subtype) ( 32574161 ) Refractive error ( 32231278 ) Schizophrenia x sex interaction ( 34099189 )	Heel bone mineral density ( 30598549 ) Height ( 31562340 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		6 interacting genes: E2F1 ESR1 H3-4 H3C1 MDM2 RB1	83 interacting genes: ARID3A ATAD2 ATM ATR BIN1 BIRC2 BRCA1 BRD2 BRMS1 BTRC CCNA1 CCNA2 CCNF CDK1 CDK2 CDK3 CDK7 CDKN2A CEBPE CHEK2 CREBBP CTDP1 CUL1 CUL2 DDB2 DIABLO E2F6 EP300 ERCC3 FHL2 GSK3B GTF2H1 HCFC1 IGF1 KAT5 KDM1A MDM4 MGA MNAT1 MTA1 MYBL2 NCOA3 NCOA6 NCOR2 NDN NFKB1 NPDC1 NRIP1 NSMCE3 PARP1 PHB1 PKIB PRDM2 PURA RARA RB1 RBL1 RNF126 RNF144A SERTAD2 SETD7 SIRT1 SKP2 SP1 SP2 SP3 SP4 SPIB STAT1 STOML1 SZRD1P1 TBP TEAD3 TFDP1 TFDP2 TOPBP1 TP53 TP53BP1 TRRAP UBE3A UCHL5 VHL YWHAQ
Entrez ID		7799	1869
HPRD ID		03120	01806
Ensembl ID		ENSG00000116731	ENSG00000101412
Uniprot IDs		Q13029	Q01094 Q9BSD8
PDB IDs		2JV0 2QPW	1H24 1O9K 2AZE 5M9N 5M9O 6G0P 6ULS 9CB3
GO Terms Enriched among Interactors		Rb-E2F Complex Cellular Response To Estrogen Stimulus Anatomical Structure Morphogenesis Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein-DNA Complex Assembly Disordered Domain Specific Binding Positive Regulation Of Extracellular Matrix Organization Transcription Regulator Complex Regulation Of Glial Cell Proliferation Chromatin Remodeling Protein-containing Complex Assembly Epithelial Cell Apoptotic Process Regulation Of DNA Binding Response To Xenobiotic Stimulus Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Fibroblast Proliferation Cellular Response To Xenobiotic Stimulus Protein-containing Complex Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Differentiation Regulation Of Developmental Process Regulation Of Epithelial Cell Apoptotic Process Protein-containing Complex Organization Response To Estrogen Cellular Component Assembly Chromatin Organization Cellular Response To Hormone Stimulus Response To Formaldehyde Cellular Response To Vitamin B1 Heart Valve Morphogenesis Regulation Of Extracellular Matrix Organization Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Differentiation Negative Regulation Of Apoptotic Process Regulation Of Cell Population Proliferation Negative Regulation Of Programmed Cell Death Structural Constituent Of Chromatin Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Fibroblast Proliferation Enzyme Binding Tissue Morphogenesis Regulation Of Myofibroblast Contraction Intracellular Signal Transduction Positive Regulation Of Mitotic Cell Cycle Phase Transition DNA-templated Transcription Regulation Of Mitotic Cell Cycle Regulation Of Gliogenesis Signal Transduction By P53 Class Mediator	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Nucleus Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Negative Regulation Of RNA Metabolic Process Chromatin Organization DNA Damage Response Chromatin Remodeling Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Repair G1/S Transition Of Mitotic Cell Cycle DNA Metabolic Process Cell Cycle G1/S Phase Transition Chromatin Cellular Response To Stress Regulation Of DNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Negative Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Apoptotic Process Protein Localization To Site Of Double-strand Break Positive Regulation Of DNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Programmed Cell Death