ZP3 and ENGASE

Number of citations: 0 (PubMedID 8269854)
Data Source: HPRD (in vitro)

		ZP3	ENGASE
Name		zona pellucida glycoprotein 3	endo-beta-N-acetylglucosaminidase
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Matrix Egg Coat	Cytoplasm Cytosol
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Carbohydrate Binding Acrosin Binding Structural Constituent Of Egg Coat Identical Protein Binding Receptor Ligand Activity	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Mannosyl-glycoprotein Endo-beta-N-acetylglucosaminidase Activity
	Biological Process	Positive Regulation Of Type IV Hypersensitivity Blastocyst Formation Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Leukocyte Migration Positive Regulation Of Humoral Immune Response Signal Transduction Single Fertilization Binding Of Sperm To Zona Pellucida Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-4 Production Egg Coat Formation Positive Regulation Of T Cell Proliferation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Oocyte Development Positive Regulation Of Inflammatory Response Positive Regulation Of Acrosome Reaction Negative Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Antral Ovarian Follicle Growth	Protein Folding N-glycan Processing
Pathways		Interaction With Cumulus Cells And The Zona Pellucida	N-glycan trimming in the ER and Calnexin/Calreticulin cycle
GWAS		Parkinson disease and lewy body pathology ( 25663231 )	No GWAS studies recorded
Interacting Genes		11 interacting genes: ACR CLDN11 ENGASE FURIN MALL MICALL1 MRPS16 OR2L13 PCDH17 SPACA3 UBAP2L	1 interacting genes: ZP3
Entrez ID		7784	64772
HPRD ID		01690	10978
Ensembl ID		ENSG00000188372	ENSG00000167280
Uniprot IDs		P21754	Q8NFI3
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Acrosomal Matrix Sperm-egg Recognition Cell-cell Recognition Cell Recognition Binding Of Sperm To Zona Pellucida Acrosome Matrix Dispersal Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Mannosyl-glycoprotein Endo-beta-N-acetylglucosaminidase Activity Cytoplasmic Side Of Endosome Membrane Amidase Activity Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Slow Endocytic Recycling Axon Ensheathment Negative Regulation Of Receptor Catabolic Process Presynaptic Active Zone Assembly Protease Binding Acrosomal Vesicle Viral Translation Viral Life Cycle Serine-type Peptidase Activity Plasma Membrane Organization Cytokine Precursor Processing Nerve Growth Factor Binding Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta1 Production Regulation Of Synaptic Vesicle Clustering Serine-type Endopeptidase Activity Fucose Binding Positive Regulation Of Stress Granule Assembly Lysozyme Activity	Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Type IV Hypersensitivity Egg Coat Formation Acrosin Binding Positive Regulation Of Antral Ovarian Follicle Growth Negative Regulation Of Binding Of Sperm To Zona Pellucida Structural Constituent Of Egg Coat Egg Coat Regulation Of Type IV Hypersensitivity Regulation Of Acrosomal Vesicle Exocytosis Regulation Of Binding Of Sperm To Zona Pellucida Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Ovarian Follicle Development Positive Regulation Of Hypersensitivity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Acrosome Reaction Positive Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Acrosome Reaction Oocyte Development Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Blastocyst Formation Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Interleukin-4 Production Binding Of Sperm To Zona Pellucida Regulation Of Interleukin-4 Production Immunoglobulin Mediated Immune Response Regulation Of Calcium Ion-dependent Exocytosis Sperm-egg Recognition Positive Regulation Of Regulated Secretory Pathway B Cell Mediated Immunity Regulation Of Humoral Immune Response Regulation Of Acute Inflammatory Response Cell-cell Recognition Negative Regulation Of Reproductive Process Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Type II Interferon Production Positive Regulation Of Reproductive Process Positive Regulation Of Exocytosis Single Fertilization Regulation Of T Cell Mediated Immunity Positive Regulation Of T Cell Proliferation Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cell Recognition Receptor Ligand Activity Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Type II Interferon Production Positive Regulation Of Lymphocyte Mediated Immunity