CACNA1E and HSPA1A

Number of citations: 0 (PubMedID 16543726)
Data Source: HPRD (in vivo)

		CACNA1E	HSPA1A
Name		calcium voltage-gated channel subunit alpha1 E	heat shock protein family A (Hsp70) member 1A
Structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex Neuronal Cell Body Synapse	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Centrosome Centriole Cytosol Cytoskeleton Plasma Membrane Focal Adhesion COP9 Signalosome Inclusion Body Aggresome Nuclear Speck Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding High Voltage-gated Calcium Channel Activity Voltage-gated Monoatomic Cation Channel Activity Metal Ion Binding	Nucleotide Binding Virus Receptor Activity G Protein-coupled Receptor Binding Transcription Corepressor Activity RNA Binding Signaling Receptor Binding Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Denatured Protein Binding Ubiquitin Protein Ligase Binding Death Receptor Agonist Activity Histone Deacetylase Binding Protein Folding Chaperone Cadherin Binding Receptor Ligand Activity Unfolded Protein Binding Misfolded Protein Binding C3HC4-type RING Finger Domain Binding Disordered Domain Specific Binding Transcription Regulator Inhibitor Activity ATP-dependent Protein Disaggregase Activity ATP-dependent Protein Folding Chaperone
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Transmembrane Transport Calcium Ion Transmembrane Transport Calcium Ion Import Across Plasma Membrane	Negative Regulation Of Transcription By RNA Polymerase II MRNA Catabolic Process Protein Folding Response To Unfolded Protein Lysosomal Transport Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Cell Growth Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Regulation Of Protein Ubiquitination Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Interleukin-8 Production Positive Regulation Of RNA Splicing Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Unfolded Protein Protein Refolding Negative Regulation Of Apoptotic Process Positive Regulation Of Erythrocyte Differentiation ATP Metabolic Process Symbiont Entry Into Host Cell Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Chaperone-mediated Protein Complex Assembly Cellular Heat Acclimation Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Microtubule Nucleation Negative Regulation Of Inclusion Body Assembly Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitotic Spindle Assembly Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Presynaptic depolarization and calcium channel opening Regulation of insulin secretion	Viral RNP Complexes in the Host Cell Nucleus Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation AUF1 (hnRNP D0) binds and destabilizes mRNA Neutrophil degranulation PKR-mediated signaling Mitochondrial unfolded protein response (UPRmt) Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation Neutrophil degranulation PKR-mediated signaling Mitochondrial unfolded protein response (UPRmt)
Drugs		Ergocalciferol Enflurane Topiramate Spironolactone Lamotrigine Nicardipine Verapamil Efonidipine Butamben Bioallethrin	None
GWAS		Body mass index (change over time) ( 25378290 ) Coronary artery calcification ( 23870195 ) Feeling hurt ( 29500382 ) Glucagon levels in response to oral glucose tolerance test (decremental area under the curve for 0-30 minutes) ( 33407418 ) Height ( 31562340 ) Intelligence (MTAG) ( 29326435 ) Lumbar spine bone mineral density (integral) ( 27476799 ) Neuroticism ( 29255261 ) Presence of antiphospholipid antibodies ( 27098658 ) Systemic mastocytosis ( 32752121 )	Asthma ( 31619474 ) Asthma (childhood onset) ( 31619474 ) Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Inflammatory bowel disease ( 28067908 ) Schizophrenia ( 30285260 ) Systemic lupus erythematosus ( 32771030 ) Ulcerative colitis ( 28067908 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		2 interacting genes: EFHC1 HSPA1A	95 interacting genes: ACE2 AIFM1 APAF1 APEX1 APOB ATXN1 BAG1 BAG2 BAG3 BAG4 BCL2 BRSK1 CACNA1E CDK9 CFAP52 DAPP1 DNAAF4 DNAJA2 DNAJA3 DNAJB1 DNAJB11 DNAJB4 DNAJC3 EGFR EIF2AK2 EIF4ENIF1 ERBB2 ERBB3 FANCC FILNC1 FNDC3B FOS FTCD GPR37 GRIN1 GRIN2D HAP1 HCFC1 HEMGN HIVEP1 HMGA1 HSBP1 HSF1 HSPA8 HSPBP1 IKBKG INS KRT18 KRT7 MAP3K5 MAPRE1 METTL21A MOS MSR1 NQO1 NR3C1 OGT PEX5 PGR PLG POT1 PPP1R15A PRKCA PSMC5 PTGES3 PTMA PTPRF RAP1A RAPGEF2 RHOA SAE1 SLC13A1 SLC5A1 SNCB SNRK SOX9 ST13 STIP1 STUB1 SUMO2 TCERG1 TGM2 TOMM70 TP53 TRIAP1 TRIM24 TRIM38 TSSK6 TTC1 UBE2D3 XIAP YWHAB YWHAG YWHAQ YWHAZ
Entrez ID		777	3303
HPRD ID		03006	00774
Ensembl ID		ENSG00000198216	ENSG00000204389
Uniprot IDs		Q15878 Q59FG1	A8K5I0 B3KTT5 P0DMV8 P0DMV9
PDB IDs		3BXL 7XLQ 7YG5 8EPL 8EPM	1HJO 1S3X 1XQS 2E88 2E8A 2LMG 3A8Y 3ATU 3ATV 3AY9 3D2E 3D2F 3JXU 3LOF 3Q49 4IO8 4J8F 4PO2 4WV5 4WV7 5AQW 5AQX 5AQY 5AQZ 5AR0 5BN8 5BN9 5BPL 5BPM 5BPN 5GJJ 5MKR 5MKS 5XI9 5XIR 6FDT 6FHK 6G3R 6G3S 6JPV 6K39 6ZYI 7F4X 7F4Z 7F50 7FGM 7GY4 7GY5 7GY6 7GY7 7GY8 7GY9 7GYA 7GYB 7GYC 7GYD 7GYE 7GYF 7GYG 7GYH 7GYI 7GYJ 7GYK 7GYL 7GYM 7GYN 7GYO 7GYP 7GYQ 7GYR 7GYS 7GYT 7GYU 7GYV 7GYW 7GYX 7KW7 7Q4R
GO Terms Enriched among Interactors		Denatured Protein Binding C3HC4-type RING Finger Domain Binding Death Receptor Agonist Activity ATP-dependent Protein Disaggregase Activity Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Cellular Response To Unfolded Protein Negative Regulation Of Inclusion Body Assembly Positive Regulation Of Erythrocyte Differentiation Aggresome Centrosome Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Inclusion Body Assembly Disordered Domain Specific Binding Negative Regulation Of Mitochondrial Membrane Permeability Inclusion Body Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Mitotic Spindle Assembly Negative Regulation Of Membrane Permeability Protein Refolding ATP-dependent Protein Folding Chaperone COP9 Signalosome Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Topologically Incorrect Protein Misfolded Protein Binding Chaperone-mediated Protein Complex Assembly Regulation Of Microtubule Nucleation Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Microtubule Nucleation Positive Regulation Of Microtubule Polymerization Regulation Of Spindle Assembly Axonemal Microtubule Cerebral Cortex Cell Migration Axonemal A Tubule Inner Sheath Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitotic Spindle Organization Positive Regulation Of RNA Splicing Transcription Regulator Inhibitor Activity Alpha-tubulin Binding Telencephalon Cell Migration Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Forebrain Cell Migration Regulation Of Erythrocyte Differentiation Negative Regulation Of Response To Endoplasmic Reticulum Stress Cellular Response To Heat Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Regulation Of Membrane Permeability Cytoskeleton	Regulation Of Programmed Cell Death Protein-folding Chaperone Binding Protein Folding Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Cytosol Positive Regulation Of Macromolecule Metabolic Process Protein Folding Chaperone Complex Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Apoptotic Process Cytoplasm Intracellular Signal Transduction Heat Shock Protein Binding Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Protein-containing Complex Intracellular Signaling Cassette Ubiquitin Protein Ligase Binding Response To Stress Regulation Of Protein Metabolic Process Hsp70 Protein Binding Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Adenyl-nucleotide Exchange Factor Activity Apoptotic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Stability Response To Heat Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Programmed Cell Death Negative Regulation Of RNA Metabolic Process Cell Death Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cellular Response To Oxygen-containing Compound Regulation Of Signal Transduction Negative Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Response To Temperature Stimulus Neuron Apoptotic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction