ZNF174 and ZKSCAN8

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (two hybrid, affinity chromatography technology)

		ZNF174	ZKSCAN8
Name		zinc finger protein 174	zinc finger with KRAB and SCAN domains 8
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nuclear Body	Nucleus Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		None	Generic Transcription Pathway
GWAS		No GWAS studies recorded	Alanine aminotransferase levels ( 33547301 ) Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Brain morphology (MOSTest) ( 32665545 ) Fish- and plant-related diet ( 32066663 ) Mean corpuscular volume ( 27863252 ) Refractive error ( 32231278 ) Smoking status (ever vs never smokers) ( 30643258 ) Subcortical volume (MOSTest) ( 32665545 )
Interacting Genes		8 interacting genes: CDK6 MZF1 SCAND1 ZKSCAN8 ZNF20 ZNF24 ZSCAN18 ZSCAN22	10 interacting genes: APP FBXO7 MAGOH OGT PRNP TCEA2 ZNF165 ZNF174 ZNF24 ZNF587
Entrez ID		7727	7745
HPRD ID		04876	03760
Ensembl ID		ENSG00000103343	ENSG00000198315
Uniprot IDs		I3L2H2 Q15697	Q15776 Q59HG5
PDB IDs		1Y7Q	Not available
GO Terms Enriched among Interactors		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Zinc Ion Binding DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleus Cyclin D2-CDK6 Complex Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Metal Ion Binding Gliogenesis Negative Regulation Of Monocyte Differentiation Cell Dedifferentiation Type B Pancreatic Cell Development Lateral Ventricle Development Regulation Of Hematopoietic Stem Cell Differentiation	Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Copper Ion Homeostasis Copper Ion Homeostasis Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Cellular Response To Copper Ion Regulation Of Primary Metabolic Process Molecular Function Activator Activity Response To Copper Ion Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Regulation Of Amyloid Precursor Protein Catabolic Process Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Neuron Apoptotic Process DNA Binding Negative Regulation Of RNA Biosynthetic Process Regulation Of Response To Calcium Ion Positive Regulation Of Calcium-mediated Signaling Regulation Of Glycolytic Process Amylin Binding Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Cellular Response To Amyloid-beta Type 8 Metabotropic Glutamate Receptor Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Synapse Organization Regulation Of Carbohydrate Catabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Neuron Apoptotic Process Autophagy Of Mitochondrion Regulation Of ATP Metabolic Process Nucleus