ZBTB16 and AGTR2

Number of citations: 51 (PubMedID 14657020)
Data Source: HPRD (two hybrid, in vitro)

		ZBTB16	AGTR2
Name		zinc finger and BTB domain containing 16	angiotensin II receptor type 2
Structure
GO Annotations	Cellular Component	Male Germ Cell Nucleus Nucleus Cytosol Nuclear Body PML Body Nuclear Speck Transcription Repressor Complex Protein-containing Complex	Plasma Membrane Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding Type 2 Angiotensin Receptor Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	G Protein-coupled Receptor Activity Angiotensin Type II Receptor Activity Protein Binding Receptor Antagonist Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Mesonephros Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Central Nervous System Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Embryonic Pattern Specification Anterior/posterior Pattern Specification Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Hemopoiesis Myeloid Cell Differentiation Positive Regulation Of Chondrocyte Differentiation Protein Localization To Nucleus Embryonic Hindlimb Morphogenesis Forelimb Morphogenesis Hindlimb Morphogenesis Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Ossification Involved In Bone Maturation Regulation Of Cell Differentiation Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Ossification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Male Germ-line Stem Cell Asymmetric Division Positive Regulation Of NK T Cell Differentiation Cartilage Development Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cartilage Development Regulation Of Multicellular Organismal Development	Blood Vessel Remodeling Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Brain Renin-angiotensin System Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Brain Development Regulation Of Blood Pressure Negative Regulation Of Heart Rate Negative Regulation Of Cell Growth Regulation Of Metanephros Size Exploration Behavior Nitric Oxide-cGMP-mediated Signaling Angiotensin-activated Signaling Pathway Vasodilation Regulation Of Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of DNA-templated Transcription Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Neuron Apoptotic Process Positive Regulation Of Metanephric Glomerulus Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Blood Vessel Diameter Maintenance Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs		None	Tasosartan CYT006-AngQb Olodanrigan
Diseases		Skeletal defects, genital hypoplasia, and mental retardation Acute myeloid leukemia (AML)	Non-syndromic X-linked mental retardation
GWAS		Basophil count ( 32888494 ) Chronotype ( 30696823 ) Conduct disorder (maternal expressed emotions interaction) ( 18846501 ) Corneal astigmatism ( 29422769 ) Diisocyanate-induced asthma ( 25918132 ) Granulocyte count ( 27863252 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean platelet volume ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 32888494 27863252 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 32888494 27863252 ) Neutrophil percentage of white cells ( 32888494 ) Non-glioblastoma glioma ( 28346443 26424050 ) Paneth cell defects in Crohn's disease ( 28352666 ) Platelet count ( 32888494 27863252 ) Plateletcrit ( 32888494 27863252 ) Polycystic ovary syndrome ( 26284813 30566500 ) Polycystic ovary syndrome (adjusted for age and BMI) ( 34791234 ) Polycystic ovary syndrome (adjusted for age) ( 34791234 ) Red blood cell count ( 32888494 ) Smoking initiation ( 33082346 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Urinary albumin-to-creatinine ratio ( 32600054 ) White blood cell count ( 27863252 32888494 )	Cystic fibrosis severity ( 21602797 ) Gestational age at birth (maternal effect) ( 28877031 ) Lung disease severity in cystic fibrosis ( 26417704 ) Offspring birth weight ( 31043758 ) Preterm birth (maternal effect) ( 28877031 ) Type 2 diabetes ( 29358691 30130595 )
Interacting Genes		155 interacting genes: ACP5 ADAMTS4 AGTR2 AMOTL2 ANAPC5 ANXA7 ATP6AP2 ATP7B BCL6 BLZF1 BMI1 CARD9 CASP3 CCDC85B CCHCR1 CD81 CDK1 CDK4 CDKN1A CEBPA CEP70 CEP72 CFH CIDEA COG6 COQ6 CRBN CTDSP1 DLST DNAAF5 DNM2 DPM1 EEF1A1 EFHC2 EIF2S2 ENOX1 EP300 EPN1 ERVK-6 ESR1 FAM217B FAM90A1 FCHO1 FHL2 FHL5 FSHR GATA1 GATA2 GCSH GNAO1 GNE GOLGA2 GOLGA6L9 GPANK1 GRB7 GSTM4 HBEGF HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC9 HDX HOXA1 HOXC5 HSF2BP ICAM3 IL6 KIAA1549 KIFC3 KRT40 KRTAP4-12 LAMTOR5 LDOC1 LMTK3 LRIG1 LSM2 LYAR MAGEA11 MAP3K3 MCUB MEOX2 MID2 MTUS2 MX1 MYLIP NCOR1 NCOR2 NFKBID NME4 NR3C1 OSBPL3 PAFAH1B3 PARP1 PGAM5 PHF1 PIAS2 PIBF1 PLSCR1 PMAIP1 PML PNRC2 PRKAR1B PSMD11 PSMD2 QTRT1 RAB27A RAB3IP RARA RB1 REL RFLNB RINT1 RUNX1T1 RXRA SH2D4A SIN3A SIN3B SMAD3 SMN1 SP1 SPOP SPRY2 SUMO1 TAB2 TERF1 THNSL2 TK1 TLE5 TOLLIP TRAF1 TRAF2 TRAF4 TRIM21 TRIM23 TRIM27 TRIM54 TTC23 TXNIP UBE2I VDR VTA1 WASHC1 WDR33 YJU2B ZBTB32 ZBTB42 ZNF24 ZNF281 ZNF552 ZNF620 ZNF655	13 interacting genes: ACE ACE2 AGT AGTRAP ARRB2 ERBB3 ERBIN GNAI2 GNAI3 MTUS1 PIK3CB SNTA1 ZBTB16
Entrez ID		7704	186
HPRD ID		11762	02071
Ensembl ID		ENSG00000109906	ENSG00000180772
Uniprot IDs		A0A024R3C6 A0A0S2Z4J5 Q05516	P50052
PDB IDs		1BUO 1CS3 8YTH	5UNF 5UNG 5UNH 5XJM 6JOD 7C6A 7JNI
GO Terms Enriched among Interactors		Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Protein Lysine Deacetylase Activity Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone Deacetylase Activity Histone Deacetylase Complex Regulation Of Primary Metabolic Process Histone Deacetylase Binding Regulation Of Gene Expression RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Cytoplasm Nucleoplasm DNA-binding Transcription Factor Binding Zinc Ion Binding Negative Regulation Of Gene Expression Nucleus Protein Binding Identical Protein Binding Transcription Coregulator Binding Enzyme Binding Negative Regulation Of Gene Expression, Epigenetic Chromatin Binding Transcription Corepressor Binding Ubiquitin Protein Ligase Binding SUMO Transferase Activity Cytosol Regulation Of Multicellular Organismal Process Epigenetic Regulation Of Gene Expression Transcription Regulator Complex Negative Regulation Of Multicellular Organismal Process Transcription Corepressor Activity Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein Deacetylation Rhythmic Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway	Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Gap Junction Assembly Angiotensin-activated Signaling Pathway Type 2 Angiotensin Receptor Binding Peptidyl-dipeptidase Activity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of Renal Output By Angiotensin Regulation Of Systemic Arterial Blood Pressure Regulation Of MAPK Cascade Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Blood Pressure Regulation Of Blood Volume By Renin-angiotensin Positive Regulation Of Gap Junction Assembly G Protein-coupled Receptor Signaling Pathway Regulation Of Heart Contraction Regulation Of Vasoconstriction Positive Regulation Of Reactive Oxygen Species Metabolic Process Plasma Membrane G Protein-coupled Receptor Binding Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Signal Transduction Regulation Of Blood Circulation Angiotensin Maturation Regulation Of System Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Transport Guanyl Nucleotide Binding Renal System Process Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation G-protein Beta/gamma-subunit Complex Binding Regulation Of Reactive Oxygen Species Metabolic Process Metallocarboxypeptidase Activity Negative Regulation Of Intracellular Signal Transduction Regulation Of Biological Quality Regulation Of Cardiac Conduction Blood Vessel Diameter Maintenance Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Tube Size Regulation Of Superoxide Metabolic Process Negative Regulation Of Catalytic Activity Carboxypeptidase Activity Negative Regulation Of MAPK Cascade Kidney Development Regulation Of Intracellular Signal Transduction Sodium Channel Regulator Activity