PCGF2 and ABHD6

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		PCGF2	ABHD6
Name		polycomb group ring finger 2	abhydrolase domain containing 6, acylglycerol lipase
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex	Mitochondrion Lysosome Lysosomal Membrane Endosome Plasma Membrane Membrane Late Endosome Membrane Mitochondrial Membrane AMPA Glutamate Receptor Complex Postsynaptic Membrane Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Metal Ion Binding Promoter-specific Chromatin Binding	Catalytic Activity Phospholipase Activity Protein Binding Hydrolase Activity Monoacylglycerol Lipase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Chromatin Organization Chromatin Remodeling Anterior/posterior Pattern Specification Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development Cellular Response To Hydrogen Peroxide Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway	Lipid Metabolic Process Phospholipid Catabolic Process Arachidonate Metabolic Process Negative Regulation Of Cell Migration Acylglycerol Catabolic Process Positive Regulation Of Lipid Biosynthetic Process Monoacylglycerol Catabolic Process Long-term Synaptic Depression Regulation Of Retrograde Trans-synaptic Signaling By Endocanabinoid Negative Regulation Of Cold-induced Thermogenesis Regulation Of Endocannabinoid Signaling Pathway Lysobisphosphatidic Acid Metabolic Process
Pathways		SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Transcriptional Regulation by E2F6	Arachidonate production from DAG
GWAS		No GWAS studies recorded	Hemoglobin levels ( 32327693 ) Platelet count ( 27863252 ) Refractive error ( 32231278 ) Rheumatoid arthritis ( 24390342 30423114 ) Systemic lupus erythematosus ( 26502338 27399966 )
Interacting Genes		26 interacting genes: ABHD6 AKT1 CBX6 CCND2 CD247 CDK2 CTNNAL1 GJB5 HOXC9 HSF2 LMNA OGT PELI2 RBCK1 RNF2 SPDEF STX2 SUMO3 TRAF2 UBE2D3 UBE2E2 UBE2Q2 UBE2T UBE2U USP11 USP7	6 interacting genes: CKMT2 FIS1 PCGF2 RTP2 SCAMP4 TVP23B
Entrez ID		7703	57406
HPRD ID		10621	12407
Ensembl ID		ENSG00000277258	ENSG00000163686
Uniprot IDs		P35227	Q9BV23
PDB IDs		Not available	7OTS
GO Terms Enriched among Interactors		Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Protein Modification Process Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Transferase Activity TORC1 Signaling Protein Metabolic Process Protein K6-linked Ubiquitination TOR Signaling Protein K48-linked Ubiquitination Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stress Protein Monoubiquitination Macromolecule Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Protein K29-linked Ubiquitination Regulation Of Cell Cycle G1/S Phase Transition Regulation Of DNA-binding Transcription Factor Activity Protein Autoubiquitination Ubiquitin Protein Ligase Activity Protein K63-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Nitric Oxide Cellular Response To Reactive Nitrogen Species Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Metabolic Process Regulation Of Protein Localization PRC1 Complex Positive Regulation Of Protein Localization To Cell Surface Ubiquitin-like Protein Transferase Activity Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of TORC1 Signaling Regulation Of Glucose Metabolic Process Response To Nitric Oxide Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cell Cycle Phase Transition PcG Protein Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process	None