ZNF138 and DHPS

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid, two hybrid)

		ZNF138	DHPS
Name		zinc finger protein 138	deoxyhypusine synthase
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Transferase Activity Deoxyhypusine Synthase Activity Identical Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Translation Spermidine Metabolic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of T Cell Proliferation Glucose Homeostasis Spermidine Catabolic Process Protein Maturation
Pathways		Generic Transcription Pathway	Hypusine synthesis from eIF5A-lysine
Drugs		None	1-Guanidinium-7-Aminoheptane
GWAS		No GWAS studies recorded	Platelet distribution width ( 32888494 )
Interacting Genes		16 interacting genes: BCCIP DHPS ELOA2 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP12-3 LHX6 LMNA MAPK9 MDFI TRIM41 ZBTB8A	16 interacting genes: BRCA1 EIF5A EIF5A2 LNX1 MEOX2 NIF3L1 NTAQ1 NUDT18 PAX6 PTPRH RAB27B RBP1 REL RPL9 VASH1 ZNF138
Entrez ID		7697	1725
HPRD ID		07244	02969
Ensembl ID		ENSG00000197008	ENSG00000095059
Uniprot IDs		A0A0A0MRG3 A0A0A0MT90 A2RRP7 C9JHF6 E7EWC5 J3QSS9 P52744	P49366
PDB IDs		Not available	1DHS 1RLZ 1ROZ 1RQD 6P4V 6PGR 6WKZ 6WL6 6XXH 6XXI 6XXJ 6XXK 6XXL 6XXM 7A6S 7A6T 8A0E 8A0F 8A0G 8PVU 8R3U
GO Terms Enriched among Interactors		Intermediate Filament Keratin Filament	Regulation Of Translational Termination Positive Regulation Of Translational Termination Positive Regulation Of Translational Elongation Regulation Of Translational Elongation Translation Elongation Factor Activity Regulation Of Protein-containing Complex Disassembly Cytoplasm Positive Regulation Of Protein-containing Complex Disassembly Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Protein-N-terminal Glutamine Amidohydrolase Activity 8-hydroxy-dADP Phosphatase Activity 8-oxo-GDP Phosphatase Activity DGDP Catabolic Process DADP Catabolic Process