YWHAG and FGD6

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology, proximity labelling technology), HPRD (in vivo)

		YWHAG	FGD6
Name		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma	FYVE, RhoGEF and PH domain containing 6
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Focal Adhesion Membrane Vesicle Synapse Extracellular Exosome Presynapse	Ruffle Cytoplasm Golgi Apparatus Cytoskeleton Lamellipodium
	Molecular Function	RNA Binding Protein Kinase C Binding Insulin-like Growth Factor Receptor Binding Protein Binding Protein Kinase C Inhibitor Activity Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Identical Protein Binding Phosphorylation-dependent Protein Binding Protein Sequestering Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding
	Biological Process	Cytoplasmic Translation Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of Protein Kinase Activity Protein Targeting Signal Transduction Intracellular Protein Localization Regulation Of Signal Transduction Positive Regulation Of Cell-cell Adhesion SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Cellular Response To Insulin Stimulus Regulation Of Protein Localization Cellular Response To Amino Acid Starvation TORC1 Signaling Cellular Response To Glucose Starvation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Neuron Differentiation Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Regulation Of Synaptic Plasticity Protein Stabilization Negative Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Protein Localization To Lysosome Protein K6-linked Ubiquitination Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling	Cytoskeleton Organization Regulation Of Cell Shape Actin Cytoskeleton Organization Regulation Of GTPase Activity Filopodium Assembly
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex AURKA Activation by TPX2 Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity SPOP-mediated proteasomal degradation of PD-L1(CD274)	None
GWAS		Multiple sclerosis ( 21654844 ) Schizophrenia ( 30285260 )	Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) ( 23648065 ) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081 ) Brain morphology (MOSTest) ( 32665545 ) Chronic obstructive pulmonary disease ( 30804561 ) Coronary artery disease ( 29212778 33020668 ) Exudative age-related macular degeneration ( 25629512 ) Hip circumference ( 28552196 ) Intracranial aneurysm ( 33199917 ) Lung function (FEV1/FVC) ( 28166213 30804560 ) Platelet count ( 32888494 ) Platelet distribution width ( 32888494 ) Pulse pressure ( 30224653 ) White matter hyperintensity volume ( 33293549 ) White matter hyperintensity volume (adjusted for hypertension) ( 33293549 )
Interacting Genes		286 interacting genes: ABL1 ABLIM1 ACIN1 AFDN AKAP13 AKT1S1 ALB ANKHD1-EIF4EBP3 ANKS1A APP ARAF ARHGEF2 ARHGEF6 ARHGEF7 ATP5F1A ATP5F1B ATP6V0B BAD BAIAP2 BAIAP2L1 BCLAF1 BCR BRAF C1QBP CAD CAMKK1 CASP3 CBL CCNY CCS CCT2 CDC5L CDK11B CDK16 CDK17 CDKN1B CEP170 CEP250 CEP95 CFAP20 CFL1 CGN CGNL1 CHAF1A CHEK1 CKAP2 CLASP1 CLINT1 CLK1 CLK2 CLK3 CLTC COPS5 CPAP CPSF3 CRTC1 CRTC2 CRTC3 CSE1L CTNND1 CTPS1 CYFIP2 DCAF7 DCP1A DDX17 DDX27 DDX39B DENND4A DFFA DHX15 DISC1 DOCK7 DYNC1H1 DYRK1A EDC3 EEF1A1 EEF1G EML3 EPB41L3 EPN2 ERC1 EWSR1 EXO1 FAM13B FARP2 FGD6 FLNA FOXO1 FOXO3 GBF1 GIT1 GIT2 GSK3A GTPBP4 H3C1 HDAC4 HDAC7 HECTD1 HGF HNRNPAB HNRNPH1 HNRNPM HOXC10 HSPA1A HSPA8 HSPA9 HSPB6 HSPD1 IGF1R IL7R ING1 INPP5E IRS1 IRS2 IRS4 JAKMIP1 KANK1 KAT5 KCNK15 KCNK3 KCNK9 KIAA0408 KIAA0930 KIF1B KIF1C KIF23 KIF5B KIF5C KLC2 KLC3 KRT18 LARP1 LATS2 LBR LIMA1 LMO7 LRCH3 LSR LTB4R LUC7L2 LUC7L3 MAGOHB MAP3K2 MAP3K20 MAP3K3 MAPKAP1 MARK3 MCM5 MDM4 MFAP1 MICALL1 MIEF1 MPHOSPH9 MPRIP MSL2 MYCBP2 MYH10 N4BP3 NCAM2 NCKAP1 NCKIPSD NDE1 NDEL1 NEDD4L NEFL NHSL2 NOLC1 NUFIP2 NUMBL OSBPL3 P4HB PABPC1 PAK1 PAK4 PARD3 PARD3B PFKFB2 PGAM5 PHLDB2 PI4KB PIK3C3 PIK3R1 PKP2 PLA2G12A PLEKHA5 PNN POT1 PPFIA1 PPFIBP1 PPIG PPP1R12A PPP6R3 PRKCA PRKCB PRKCD PRKCG PRKCQ PRKDC PRLR PRMT1 PRMT5 PRP4K PRPF38B PRPF40A PTPN14 PUF60 RAB11FIP2 RAB11FIP5 RABEP1 RACGAP1 RAF1 RAI14 RALGPS2 RAPGEF6 RASAL2 RASSF8 RGS12 RIPK2 RIPOR2 RMDN3 RNPS1 RPS2 RRM1 SAMD4A SAMD4B SF3B3 SFN SH3BP4 SH3BP5L SHKBP1 SHPRH SHROOM2 SIMC1 SLC25A3 SMARCD1 SNRNP200 SON SPOP SPTBN1 SRC SRGAP2 SRPK1 SRRM1 SRRM2 SRSF10 SRSF3 STK11 SVIL SYNPO SYNPO2 TAB1 TAF15 TBC1D1 TBC1D4 TERF1 TFE3 THRAP3 TIAM1 TINF2 TJP2 TMEM102 TNFAIP3 TP53 TP53BP2 TRA2A TRA2B TSC1 TSC2 TUBA4A TUBB TUBB4A UBC UBE3A UCP2 UCP3 USP37 USP8 WEE1 WNK1 YAP1 YWHAB YWHAE YWHAH YWHAQ ZBTB21 ZFP36	2 interacting genes: ACVR1 YWHAG
Entrez ID		7532	55785
HPRD ID		05639	16892
Ensembl ID		ENSG00000170027	ENSG00000180263
Uniprot IDs		P61981	Q6ZV73
PDB IDs		2B05 3UZD 4E2E 4J6S 4O46 5D3E 6A5S 6BYJ 6BYL 6BZD 6FEL 6GKF 6GKG 6S9K 6SAD 6Y4K 6Y6B 6ZBT 6ZC9 7A6R 7A6Y	Not available
GO Terms Enriched among Interactors		Cytosol Cytoplasm Protein Binding Regulation Of Supramolecular Fiber Organization RNA Splicing Cadherin Binding Cytoskeleton Regulation Of Protein Localization Regulation Of Cellular Component Organization Regulation Of Organelle Organization Protein Serine Kinase Activity ATP Binding Regulation Of Cytoskeleton Organization Protein Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of RNA Splicing Nucleus RNA Binding MRNA Metabolic Process Nucleotide Binding Cellular Component Assembly Focal Adhesion Intracellular Signal Transduction Kinase Activity Organelle Organization Cytoskeleton Organization MRNA Splicing, Via Spliceosome Microtubule RNA Splicing, Via Transesterification Reactions Nucleoplasm Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing MRNA Processing Regulation Of Cell Cycle Positive Regulation Of Cellular Component Organization Regulation Of Protein Metabolic Process Small GTPase Binding Nuclear Speck Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Protein-containing Complex Regulation Of Programmed Cell Death Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Actin Filament Organization Macromolecule Metabolic Process Protein Phosphorylation Anchoring Junction Negative Regulation Of Supramolecular Fiber Organization Protein Domain Specific Binding Phosphorylation	Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Endocardial Cushion Cell Fate Commitment Endocardial Cushion Formation Atrial Septum Primum Morphogenesis Cell Adhesion Involved In Heart Morphogenesis Positive Regulation Of Determination Of Dorsal Identity Endocardial Cushion Fusion Activin Binding BMP Receptor Activity Cardiac Muscle Cell Fate Commitment Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Activity, Type I Epithelial Cell Fate Commitment Mitral Valve Morphogenesis BMP Receptor Complex Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Protein Kinase C Inhibitor Activity Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Phosphorylation-dependent Protein Binding Muscle Cell Fate Commitment Negative Regulation Of Immune Response To Tumor Cell Negative Regulation Of Activin Receptor Signaling Pathway Atrial Septum Morphogenesis Regulation Of T Cell Mediated Immune Response To Tumor Cell Insulin-like Growth Factor Receptor Binding Gastrulation With Mouth Forming Second Pharyngeal System Development Positive Regulation Of Immune Response To Tumor Cell Transforming Growth Factor Beta Binding Atrioventricular Valve Morphogenesis Circulatory System Development Regulation Of Activin Receptor Signaling Pathway Protein K6-linked Ubiquitination Smooth Muscle Cell Differentiation Outflow Tract Septum Morphogenesis Endothelial Cell Differentiation Activin Receptor Signaling Pathway Cellular Response To BMP Stimulus Regulation Of Response To Tumor Cell Branching Involved In Blood Vessel Morphogenesis Positive Regulation Of Intracellular Signal Transduction Peptide Hormone Binding Negative Regulation Of T Cell Mediated Immunity Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Protein Tyrosine Kinase Binding Positive Regulation Of Bone Mineralization Protein Sequestering Activity