XBP1 and NR0B2

Number of citations: 41 (PubMedID 20211142)
Data Source: BioGRID (two hybrid)

		XBP1	NR0B2
Name		X-box binding protein 1	nuclear receptor subfamily 0 group B member 2
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Protein-containing Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Protease Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Nuclear Estrogen Receptor Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding Ubiquitin-like Protein Ligase Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity Protein Binding Nuclear Receptor Binding Protein Domain Specific Binding Protein Homodimerization Activity Nuclear Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Protein-containing Complex Binding Nuclear Retinoid X Receptor Binding Nuclear Thyroid Hormone Receptor Binding Transcription Regulator Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of Cell Growth Liver Development Positive Regulation Of Protein Phosphorylation Endothelial Cell Proliferation Glandular Epithelial Cell Maturation Positive Regulation Of Immunoglobulin Production Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Lipid Metabolic Process Fatty Acid Biosynthetic Process Autophagy Apoptotic Process Immune Response Response To Unfolded Protein Muscle Organ Development Positive Regulation Of Cell Population Proliferation Regulation Of Autophagy Positive Regulation Of Autophagy Negative Regulation Of Myotube Differentiation Protein Transport Cell Differentiation Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Exocrine Pancreas Development Regulation Of Protein Stability Protein Destabilization Cellular Response To Nutrient Positive Regulation Of TOR Signaling Positive Regulation Of Interleukin-6 Production Cellular Response To Insulin Stimulus Cellular Response To Oxidative Stress Response To Endoplasmic Reticulum Stress Intracellular Triglyceride Homeostasis Positive Regulation Of Vascular Wound Healing Cellular Response To Vascular Endothelial Growth Factor Stimulus IRE1-mediated Unfolded Protein Response ATF6-mediated Unfolded Protein Response ERAD Pathway Cellular Response To Glucose Starvation Positive Regulation Of Protein Import Into Nucleus Cholesterol Homeostasis Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Fatty Acid Homeostasis Sterol Homeostasis Negative Regulation Of SMAD Protein Signal Transduction Adipose Tissue Development Epithelial Cell Maturation Involved In Salivary Gland Development Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Phospholipid Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Fructose Stimulus Cellular Response To Glucose Stimulus Cellular Response To Interleukin-4 Cellular Response To Peptide Hormone Stimulus Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Positive Regulation Of Plasma Cell Differentiation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Acetylation Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lactation Positive Regulation Of ERAD Pathway Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Response To Insulin-like Growth Factor Stimulus Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Endothelial Cell Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Circadian Rhythm Cholesterol Metabolic Process Response To Glucose Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Animal Organ Regeneration Positive Regulation Of Insulin Secretion Circadian Regulation Of Gene Expression Negative Regulation Of DNA-binding Transcription Factor Activity Response To Ethanol Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Rhythmic Process
Pathways		None	Nuclear Receptor transcription pathway
GWAS		Esophageal cancer (squamous cell) ( 22960999 ) Esophageal squamous cell carcinoma ( 25129146 ) Heel bone mineral density ( 28869591 ) Mean arterial pressure ( 29403010 ) Pancreatic cancer ( 25086665 ) Serum alkaline phosphatase levels ( 33547301 )	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143 ) HDL cholesterol ( 24097068 ) LDL cholesterol ( 24097068 ) Triglycerides ( 24097068 )
Interacting Genes		22 interacting genes: ATF6 ATF6B CREBZF ESR1 FOS FUBP3 GLI1 H1-0 H1-10 HDGF MDM2 MTNR1B NR0B2 PCBD2 RBL2 SRSF1 SSX4 TRIP4 UBE2I UBE2V1 ZNF440 ZNF580	51 interacting genes: AR CHRD CIDEC DDX20 EID1 ESR1 ESR2 ESRRA ESRRG FN1 GPS2 GPSM3 HDAC3 HDAC6 HNF4A HNF4G HNRNPA1 ID2 IL3RA NCOA3 NEUROD1 NR1H2 NR1H3 NR1I2 NR1I3 NR3C1 NR5A2 PAX9 PEF1 PLSCR1 POLR2A PPARD PPARG RARA RARG RBP5 RNF31 RXRA RXRB RXRG SMAD4 SMARCA2 SMARCB1 SMARCE1 SNW1 THRA TP53 VDR XBP1 ZAP70 ZMYND10
Entrez ID		7494	8431
HPRD ID		01908	05219
Ensembl ID		ENSG00000100219	ENSG00000131910
Uniprot IDs		B1AHH1 P17861	Q15466
PDB IDs		6R5Q 6R6G 6R6P 6R7Q	1YUC 2Q3Y 2Z4J 4DOR 4ONI 5UFS 6W9M 7YXC 7YXD 7YXN 7YXO 7YXP 7YXR
GO Terms Enriched among Interactors		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process ATF6-mediated Unfolded Protein Response Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleus DNA Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Chromatin Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Transcription By RNA Polymerase II ER-nucleus Signaling Pathway DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Coregulator Binding RNA Polymerase II Transcription Regulator Complex Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Animal Organ Regeneration Negative Regulation Of Nucleobase-containing Compound Metabolic Process Peroxisome Proliferator Activated Receptor Binding Transcription Repressor Complex Endoplasmic Reticulum Unfolded Protein Response RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cellular Response To Estrogen Stimulus SUMO Transferase Activity Transcription Cis-regulatory Region Binding Cellular Response To Reactive Oxygen Species Estrogen Receptor Signaling Pathway Response To Immobilization Stress Chromatin Organization Negative Regulation Of Macromolecule Metabolic Process Liver Regeneration Regeneration Sequence-specific Double-stranded DNA Binding Regulation Of Endoplasmic Reticulum Unfolded Protein Response Nuclear Estrogen Receptor Binding	Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Hormone-mediated Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Retinoic Acid Receptor Signaling Pathway Chromatin Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA Binding Nuclear Steroid Receptor Activity RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Nucleoplasm DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Transcription By RNA Polymerase II Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Cellular Developmental Process Cell Differentiation MRNA Transcription DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process