WAS and ARPC1B

Number of citations: 0 (PubMedID 11943145)
Data Source: HPRD (in vitro)

		WAS	ARPC1B
Name		WASP actin nucleation promoting factor	actin related protein 2/3 complex subunit 1B
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Vesicle Membrane Actin Cytoskeleton Membrane Site Of Double-strand Break Phagocytic Vesicle Extracellular Exosome	Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Tubulobulbar Complex Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding SH3 Domain Binding Protein Kinase Binding GTPase Regulator Activity Small GTPase Binding Identical Protein Binding Phospholipase Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Protein-containing Complex Binding Actin Filament Binding
	Biological Process	Regulation Of T Cell Antigen Processing And Presentation Defense Response Immune Response Actin Filament Organization Rho Protein Signal Transduction Blood Coagulation Regulation Of Actin Polymerization Or Depolymerization Actin Polymerization Or Depolymerization Epidermis Development Regulation Of Lamellipodium Assembly Endosomal Transport Actin Filament Polymerization Actin Filament-based Movement Cdc42 Protein Signal Transduction T Cell Activation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Protein-containing Complex Assembly Cellular Response To Type II Interferon Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell Motility Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Response To Estradiol Arp2/3 Complex-mediated Actin Nucleation Response To Estrogen
Pathways		Generation of second messenger molecules Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs CDC42 GTPase cycle RAC1 GTPase cycle RHOJ GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		(S)-wiskostatin	N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases		Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM) Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)	None
GWAS		Platelet distribution width ( 32888494 )	Alcohol consumption ( 31358974 ) Facial emotion recognition (sad faces) ( 28608620 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Serum metabolite levels ( 23093944 )
Interacting Genes		61 interacting genes: ABI3 ACTC1 ACTR2 APBB1 APPBP2 ARHGAP1 ARHGEF7 ARPC1B ARPC2 ARPC3 BAIAP2L1 BTK C5AR1 CDC42 CIB1 CREBBP CRKL CSNK2A1 CSNK2A2 DLG1 DVL2 ENAH EVL FCHSD2 FGR FYB1 FYN GRB2 HCK HCLS1 ITK ITSN2 LCK LCP2 NCK1 NCK2 NCKIPSD PIK3R1 PLCG1 PRPF40A PSTPIP1 PTPN12 RAC1 RANBP2 RGS14 RHOJ RPA1 RPA2 RPA3 SNX9 SORBS2 SRC TCERG1 TEC TNK2 TRIP10 UBASH3A VASP WBP4 WIPF1 WIPF2	11 interacting genes: ACTB ACTR2 APP ARPC2 ARPC4 ARPC5 AURKA CEBPA PAK1 SRPK2 WAS
Entrez ID		7454	10095
HPRD ID		02314	10366
Ensembl ID		ENSG00000015285	ENSG00000130429
Uniprot IDs		A0A8V8TM35 P42768	A4D275 O15143
PDB IDs		1CEE 1EJ5 1T84 2A3Z 2K42 2OT0	6UHC 6YW6 8P94
GO Terms Enriched among Interactors		Positive Regulation Of Actin Filament Polymerization Actin Filament Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Protein Polymerization Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament Organization Regulation Of Supramolecular Fiber Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Lamellipodium Supramolecular Fiber Organization Immune Response-activating Signaling Pathway Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Supramolecular Fiber Organization Immune Response-regulating Signaling Pathway Activation Of Immune Response Positive Regulation Of Cytoskeleton Organization Regulation Of Cellular Component Size Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Cytosol Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway Cytoplasm Regulation Of Lamellipodium Organization Positive Regulation Of Cellular Component Organization Focal Adhesion Positive Regulation Of Immune System Process Regulation Of Cellular Component Organization Positive Regulation Of Lamellipodium Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Immune Response Cell Projection SH3 Domain Binding Regulation Of Immune System Process Phosphotyrosine Residue Binding Regulation Of Organelle Organization Regulation Of Immune Response Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction Signal Transduction Protein Tyrosine Kinase Activity Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization	Arp2/3 Protein Complex Arp2/3 Complex-mediated Actin Nucleation Actin Nucleation Structural Constituent Of Cytoskeleton Site Of Double-strand Break Actin Cytoskeleton Actin Filament Supramolecular Fiber Organization Actin Filament Organization Actin Filament Polymerization Cytoskeleton Regulation Of Lamellipodium Assembly Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Actin Binding Regulation Of Supramolecular Fiber Organization Regulation Of Lamellipodium Organization Actin Filament-based Process Focal Adhesion Lamellipodium Actin Polymerization Or Depolymerization Cell Projection Actin Filament Binding Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Presynapse Positive Regulation Of DNA Recombination Protein Polymerization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Response To Cytokine Regulation Of Actin Filament Organization Response To Peptide Positive Regulation Of Double-strand Break Repair Nucleus Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Chromatin Remodeling Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Projection Organization Cellular Component Assembly Regulation Of Actin Cytoskeleton Organization Actin Cytoskeleton Organization Cytosol Regulation Of Cellular Component Organization Regulation Of Organelle Organization Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of DNA Recombination Positive Regulation Of DNA Repair