WARS1 and MDH2

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		WARS1	MDH2
Name		tryptophanyl-tRNA synthetase 1	malate dehydrogenase 2
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Protein-containing Complex Extracellular Exosome	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Aminoacyl-tRNA Ligase Activity Tryptophan-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity Kinase Inhibitor Activity Protein Kinase Binding Protein Domain Specific Binding Protein Homodimerization Activity	RNA Binding Catalytic Activity Oxidoreductase Activity Malate Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor L-malate Dehydrogenase (NAD+) Activity Identical Protein Binding L-malate Dehydrogenase (NADP+) Activity
	Biological Process	Angiogenesis Translation TRNA Aminoacylation For Protein Translation Tryptophanyl-tRNA Aminoacylation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Protein-containing Complex Assembly Regulation Of Angiogenesis	Gluconeogenesis Tricarboxylic Acid Cycle Malate Metabolic Process Aerobic Respiration NAD+ Metabolic Process Carboxylic Acid Metabolic Process Malate-aspartate Shuttle
Pathways		Cytosolic tRNA aminoacylation	Citric acid cycle (TCA cycle) Mitochondrial protein degradation Malate-aspartate shuttle
Drugs		Tryptophan Tryptophanyl-5'amp Tryptophanamide	NADH Citric acid Xanthinol
GWAS		No GWAS studies recorded	Coffee consumption ( 31959922 )
Interacting Genes		15 interacting genes: APP CDK2AP2 CEBPA DCAF13 DNMT3B DSCAM EEF1A1 FILNC1 LCOR LIG4 LINC01554 MDH2 OGT TERF1 UBC	11 interacting genes: CRYAB CS FH GOT2 HSPB1 LINC00632 NDUFS1 PC PSMA1 SHANK3 WARS1
Entrez ID		7453	4191
HPRD ID		01845	01099
Ensembl ID		ENSG00000140105	ENSG00000146701
Uniprot IDs		A0A024R6K8 P23381	A0A024R4K3 B3KTM1 G3XAL0 P40926
PDB IDs		1O5T 1R6T 1R6U 1ULH 2AKE 2AZX 2DR2 2QUH 2QUI 2QUJ 2QUK 5UJI 5UJJ	2DFD 4WLE 4WLF 4WLN 4WLO 4WLU 4WLV
GO Terms Enriched among Interactors		Positive Regulation Of Proteolysis Amyloid-beta Complex Growth Cone Lamellipodium Central Nervous System Development Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Neuron Recognition Nucleus Cellular Response To Metal Ion Response To Lithium Ion Cellular Response To Lithium Ion RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates Establishment Of Integrated Proviral Latency L-malate Dehydrogenase (NADP+) Activity Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Nuclear Estrogen Receptor Binding Regulation Of Glycolytic Process Negative Regulation Of Transcription By RNA Polymerase II Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of ATP Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Carbohydrate Catabolic Process Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Chromatin DNA Binding CHOP-C/EBP Complex Stem Cell Proliferation Response To Vitamin B2 C/EBP Complex DNA-methyltransferase Activity DNA (cytosine-5-)-methyltransferase Activity Post-embryonic Retina Morphogenesis In Camera-type Eye	Mitochondrial Matrix Contractile Muscle Fiber Extracellular Exosome Protein Refolding Tricarboxylic Acid Cycle Mitochondrion NAD+ Metabolic Process Citrate Synthase Activity Fumarate Metabolic Process Fumarate Hydratase Activity Amino Acid Metabolic Process Negative Regulation Of Protein Kinase C Signaling Pyruvate Carboxylase Activity Small Molecule Metabolic Process Acyltransferase Activity, Acyl Groups Converted Into Alkyl On Transfer Catalytic Activity L-glutamate Catabolic Process To Aspartate L-aspartate:2-oxoglutarate Aminotransferase Activity Aspartate Biosynthetic Process Purine Nucleotide Metabolic Process Proteasome Complex Viral RNA Genome Packaging Tryptophan-tRNA Ligase Activity Tryptophanyl-tRNA Aminoacylation Guanylate Kinase-associated Protein Clustering Response To Heat Dicarboxylic Acid Metabolic Process L-aspartate Catabolic Process Nucleotide Metabolic Process Protein Kinase C Inhibitor Activity Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Unfolded Protein Binding Z Disc Citrate Metabolic Process Regulation Of Arginine Metabolic Process Nicotinamide Nucleotide Metabolic Process Trans-4-hydroxy-L-proline Catabolic Process Kynurenine-oxoglutarate Transaminase Activity Purine-containing Compound Metabolic Process Regulation Of Protein Kinase C Signaling Ligase Activity Biotin Binding Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity NMDA Glutamate Receptor Clustering