VCL and NRAP

Number of citations: 0 (PubMedID 10320340)
Data Source: BioGRID (pull down), HPRD (in vitro)

		VCL	NRAP
Name		vinculin	nebulin related anchoring protein
Structure			No pdb structure
GO Annotations	Cellular Component	Podosome Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Brush Border Cell-cell Junction Adherens Junction Zonula Adherens Fascia Adherens Focal Adhesion Actin Cytoskeleton Membrane Myofibril Cell-substrate Junction Protein-containing Complex Secretory Granule Lumen Specific Granule Lumen Sarcolemma Cell Projection Costamere Cell-cell Contact Zone Membrane Raft Perinuclear Region Of Cytoplasm Podosome Ring Extracellular Exosome Anchoring Junction Outer Dense Plaque Of Desmosome Inner Dense Plaque Of Desmosome Extracellular Vesicle Ficolin-1-rich Granule Lumen Terminal Web	Cytoplasm Fascia Adherens Muscle Tendon Junction Myofibril Z Disc
	Molecular Function	Dystroglycan Binding Actin Binding Structural Molecule Activity Protein Binding Beta-catenin Binding Ubiquitin Protein Ligase Binding Alpha-catenin Binding Cadherin Binding Molecular Adaptor Activity	Actin Binding Protein Binding Vinculin Binding Metal Ion Binding Actin Filament Binding Muscle Alpha-actinin Binding
	Biological Process	Morphogenesis Of An Epithelium Cell Adhesion Cell-matrix Adhesion Lamellipodium Assembly Regulation Of Cell Migration Negative Regulation Of Cell Migration Adherens Junction Assembly Protein Localization To Cell Surface Maintenance Of Blood-brain Barrier Apical Junction Assembly Axon Extension Regulation Of Focal Adhesion Assembly Platelet Aggregation Epithelial Cell-cell Adhesion Regulation Of Establishment Of Endothelial Barrier Regulation Of Protein Localization To Adherens Junction	Cardiac Muscle Thin Filament Assembly
Pathways		Platelet degranulation Smooth Muscle Contraction MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants Signaling by ALK fusions and activated point mutants Regulation of CDH1 Function High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	None
GWAS		Cardiac troponin-I levels ( 31014085 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Left ventricular internal dimension in diastole ( 29403010 ) Primary tooth development (number of teeth) ( 23704328 ) Primary tooth development (time to first tooth eruption) ( 23704328 ) Refractive error ( 32231278 )	Heel bone mineral density ( 30598549 ) Plasma factor VII activating protease levels ( 30070759 ) QT interval ( 29874175 )
Interacting Genes		38 interacting genes: ABI2 ACTA1 ACTN1 BCAR1 BIRC6 BRME1 CDH1 CLTC CORO2B CTNNA1 ENOX2 GSN ITGA5 LINC01554 LPXN NEBL NRAP PKD1 POMP PRKCA PRPF40A PSME1 PTK2 PXN RAVER1 SAPCD2 SELE SORBS1 SORBS2 SORBS3 SRC TEKT1 TGFB1I1 TLN1 TRIM15 TRIP6 TUBA1A VASP	8 interacting genes: ACTA1 ACTB ACTN3 KLHL41 PRKAA2 TLN1 TRIM63 VCL
Entrez ID		7414	4892
HPRD ID		01900	04189
Ensembl ID		ENSG00000035403	ENSG00000197893
Uniprot IDs		B3KXA2 P18206 V9HWK2	A0A0A0MRM2 Q86VF7
PDB IDs		1RKC 1RKE 1SYQ 1TR2 1YDI 2GWW 2HSQ 2IBF 3H2U 3H2V 3JBK 3MYI 3RF3 3S90 3TJ5 3TJ6 3VF0 4DJ9 4EHP 4LN2 4LNP 4PR9 5L0C 5L0D 5L0F 5L0G 5L0H 5L0I 5L0J 5O2Q 6FUY 6UPW 7KTT 7KTU 7KTV 7KTW	Not available
GO Terms Enriched among Interactors		Anchoring Junction Focal Adhesion Vinculin Binding Cell-substrate Junction Assembly Cell-substrate Junction Organization Cell Junction Assembly Cell Adhesion Cytoskeleton Actin Filament Organization Cell Junction Organization Lamellipodium Supramolecular Fiber Organization Stress Fiber Cellular Component Assembly Focal Adhesion Assembly Actin Cytoskeleton Cytoplasm Cell-substrate Adhesion Integrin-mediated Signaling Pathway Cytoskeleton Organization Actin Binding Cell Motility Actin Filament Binding Cell Migration Signal Complex Assembly Integrin Binding Flotillin Complex Regulation Of Cytoskeleton Organization Actin Filament-based Process Structural Constituent Of Cytoskeleton Regulation Of Cell Adhesion Cell-cell Junction Assembly Negative Regulation Of Anoikis Actin Cytoskeleton Organization Cardiac Muscle Thin Filament Assembly Cytoskeletal Protein Binding Regulation Of Actin Filament Organization Regulation Of Anoikis Regulation Of Cellular Component Organization Positive Regulation Of Supramolecular Fiber Organization Actin Filament Plasma Membrane Cell-cell Junction Organization Cellular Response To Indole-3-methanol Cytosol Positive Regulation Of Cytoskeleton Organization Cell Projection Adherens Junction Protein-containing Complex Assembly Vascular Endothelial Growth Factor Receptor Signaling Pathway	Muscle System Process Actin Cytoskeleton Brush Border Cell Junction Assembly Platelet Aggregation Homotypic Cell-cell Adhesion Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Regulation Of Glycolytic Process Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Actin Filament Muscle Atrophy Regulation Of Purine Nucleotide Metabolic Process Structural Constituent Of Cytoskeleton Actin Cytoskeleton Organization Actin Filament-based Process Cell-cell Junction Assembly Adherens Junction Assembly Focal Adhesion Regulation Of Generation Of Precursor Metabolites And Energy Pseudopodium Cell Junction Organization Negative Regulation Of Glycolytic Process Negative Regulation Of ATP Metabolic Process M Band Cell-cell Junction Organization Adherens Junction Muscle Contraction Maintenance Of Blood-brain Barrier Cell-substrate Junction Assembly Cell-substrate Junction Organization Cytoskeleton Adherens Junction Organization Sarcomere Regulation Of Small Molecule Metabolic Process Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Regulation Of Focal Adhesion Assembly Inner Dense Plaque Of Desmosome Podosome Ring Outer Dense Plaque Of Desmosome Regulation Of Myoblast Differentiation Actin Binding Regulation Of Cell-substrate Junction Organization Cytoskeleton Organization Cytoplasm Muscle Cell Development