UBE2H and POLM

Number of citations: 0 (PubMedID 17588522)
Data Source: BioGRID (enzymatic study)

		UBE2H	POLM
Name		ubiquitin conjugating enzyme E2 H	DNA polymerase mu
Structure
GO Annotations	Cellular Component	Nucleus Cytosol	Nucleus Nucleoplasm
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Transferase Activity Nucleotidyltransferase Activity DNA Polymerase Activity Metal Ion Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	DNA Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Somatic Hypermutation Of Immunoglobulin Genes B Cell Differentiation DNA Biosynthetic Process
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Nonhomologous End-Joining (NHEJ)
GWAS		Estimated glomerular filtration rate ( 31152163 31451708 ) Lymphocyte count ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte count ( 32888494 ) Response to antidepressants and depression ( 27622933 ) White blood cell count ( 32888494 )	No GWAS studies recorded
Interacting Genes		71 interacting genes: BRAP CBLC CD99 CDK2 DTX3 DTX3L DZIP3 EPS15 GID4 GOLGA2 H2AC18 H2AC20 HBP1 HDAC6 JADE1 LNX2 LRSAM1 MAEA MARCHF1 MARCHF10 MARCHF2 MARCHF4 MARCHF8 MDM2 MKRN3 NEURL1 NEURL2 NHLRC1 POLL POLM PRKN PSME3 RAG1 RBX1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 STUB1 TLE5 TRAIP TRIM13 TRIM17 TRIM2 TRIM23 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 TRIM69 TRIM72 UBASH3B UBOX5 UBR2 UBR3	14 interacting genes: CEP55 CTAG1A CTAG1B IKZF3 OGT PCNA PNMA1 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H USHBP1
Entrez ID		7328	27434
HPRD ID		03052	16208
Ensembl ID		ENSG00000186591	ENSG00000122678
Uniprot IDs		A0A3B3IU20 A4D1L5 P62256	Q9NP87
PDB IDs		2Z5D 8PJN	2DUN 2HTF 4LZD 4LZG 4M04 4M0A 4YCX 4YD1 4YD2 5TWP 5TWQ 5TWR 5TWS 5TXX 5TXZ 5TYB 5TYC 5TYD 5TYE 5TYF 5TYG 5TYU 5TYV 5TYW 5TYX 5TYY 5TYZ 5VZ7 5VZ8 5VZ9 5VZA 5VZB 5VZC 5VZD 5VZE 5VZF 5VZG 5VZH 5VZI 5W4F 5ZLC 6AEC 6AEH 6AK5 6AK6 6AK8 6AK9 6AKH 6IPD 6IPE 6IPF 6IPG 6IPH 6IPI 6IPJ 6IPK 6IPL 6IPM 6IPN 6P1M 6P1N 6P1O 6P1P 6P1Q 6P1R 6P1S 6P1T 6P1U 6P1V 6P1W 6VEZ 6VF0 6VF1 6VF2 6VF3 6VF4 6VF5 6VF6 6VF7 6VF8 6VF9 6VFA 6VFB 6VFC 6WIC 6WID 6WIE 7CO6 7CO8 7CO9 7COA 7COB 7COC 7COD 7KSS 7KST 7KSU 7KSV 7KSW 7KSX 7KSY 7KSZ 7KT0 7KT1 7KT2 7KT3 7KT4 7KT5 7KT6 7KT7 7KT8 7KT9 7KTA 7KTB 7KTC 7KTD 7KTE 7KTF 7KTG 7KTH 7KTI 7KTJ 7KTK 7KTL 7KTM 7KTN
GO Terms Enriched among Interactors		Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Transferase Activity Protein Modification Process Zinc Ion Binding Protein Metabolic Process Protein Polyubiquitination Metal Ion Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Autoubiquitination Macromolecule Metabolic Process Macromolecule Catabolic Process Proteolysis Protein Catabolic Process Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Protein Monoubiquitination Ubiquitin Protein Ligase Binding Protein K63-linked Ubiquitination Autophagy Positive Regulation Of Catabolic Process Cytoplasm Endoplasmic Reticulum Mannose Trimming Protein K48-linked Ubiquitination Regulation Of Protein Catabolic Process Protein Alpha-1,2-demannosylation Suppression Of Viral Release By Host Immune System Process Protein Deglycosylation Aggresome Assembly Innate Immune Response Positive Regulation Of Protein Catabolic Process ERAD Pathway Endoplasmic Reticulum Quality Control Compartment Cellular Response To Stress Protein K6-linked Ubiquitination Ubiquitin Binding Inclusion Body Assembly Response To Endoplasmic Reticulum Stress Positive Regulation Of Autophagy Aggresome Defense Response To Symbiont Defense Response To Other Organism	Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Polyubiquitination Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K11-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteolysis Post-translational Protein Modification Macromolecule Catabolic Process TRNA Threonylcarbamoyladenosine Metabolic Process Protein Modification Process Ubiquitin Protein Ligase Activity Transferase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Catabolic Process ATP Binding Regulation Of Protein Ubiquitination Proteasomal Protein Catabolic Process PCNA Complex Replisome Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Post-translational Protein Modification Protein Monoubiquitination Macromolecule Metabolic Process Protein Catabolic Process TORC1 Signaling Negative Regulation Of BMP Signaling Pathway PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Nucleotide Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Autoubiquitination TOR Signaling Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Regulation Of Cellular Response To Growth Factor Stimulus Protein O-acetylglucosaminyltransferase Activity Regulation Of TORC1 Signaling Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation ISG15 Transferase Activity Positive Regulation Of Exit From Mitosis Positive Regulation Of Protein Ubiquitination