UBE2D2 and TRIM32

Number of citations: 40 (PubMedID 25701873)
Data Source: BioGRID (pull down)

		UBE2D2	TRIM32
Name		ubiquitin conjugating enzyme E2 D2	tripartite motif containing 32
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Protein-containing Complex Extracellular Exosome	Nucleus Cytoplasm Mitochondrion Autophagosome Endoplasmic Reticulum Centrosome Cytosol Striated Muscle Myosin Thick Filament
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Myosin Binding Protein-macromolecule Adaptor Activity Tat Protein Binding Translation Initiation Factor Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification Process Protein Autoubiquitination Protein K48-linked Ubiquitination	Autophagosome Assembly Protein Polyubiquitination Tissue Homeostasis Ubiquitin-dependent Protein Catabolic Process Response To Oxidative Stress Actin Ubiquitination Response To UV Positive Regulation Of Catabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Autophagy Positive Regulation Of Macromolecule Biosynthetic Process Free Ubiquitin Chain Polymerization Protein Ubiquitination Cellular Homeostasis Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Negative Regulation Of Viral Transcription Cellular Response To Stress Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Amino Acid Starvation Response To Tumor Necrosis Factor Response To Starvation Positive Regulation Of Canonical NF-kappaB Signal Transduction Suppression Of Viral Release By Host Innate Immune Response Fat Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Positive Regulation Of DNA-templated Transcription Muscle Cell Cellular Homeostasis Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis Positive Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Protein Metabolic Process Cilium Assembly Axon Development Cytosolic Ciliogenesis Protein K63-linked Ubiquitination Negative Regulation Of Cilium Assembly Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Interleukin-17-mediated Signaling Pathway Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Protein Localization To Phagocytic Vesicle Positive Regulation Of Cell Motility Positive Regulation Of Autophagosome Assembly
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation PINK1-PRKN Mediated Mitophagy Regulation of TNFR1 signaling CLEC7A (Dectin-1) signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Regulation of innate immune responses to cytosolic DNA Antigen processing: Ubiquitination & Proteasome degradation
Drugs		(R,R)-2,3-Butanediol	None
Diseases		None	Bardet-Biedl syndrome (BBS)
GWAS		Alzheimer's disease (late onset) ( 30820047 ) Body mass index ( 26426971 ) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502 ) Leukocyte telomere length ( 32109421 )	Estimated glomerular filtration rate ( 31015462 ) Hip circumference adjusted for BMI ( 34021172 )
Interacting Genes		244 interacting genes: AMFR ANAPC11 ANAPC2 AREL1 ARIH2 ARRDC3 BARD1 BFAR BIRC2 BIRC3 BIRC7 BIRC8 BMI1 BRAP BRCA1 BTRC CADPS2 CBL CBLB CBLC CCNB1 CDKN1B CHFR CNOT4 COP1 CUEDC1 CUL3 DCAF1 DTX1 DTX2 DTX3 DTX3L DZIP3 EPS15 F12 FBXL3 FBXO2 FBXO4 FBXO7 FBXW2 HACE1 HECTD1 HECTD3 HECTD4 HECW1 HECW2 HERC1 HERC2 HERC4 HUWE1 ITCH KAT2B KCMF1 LNX1 LNX2 LRSAM1 LTN1 MAP3K1 MAPT MARCHF3 MARCHF5 MARCHF6 MARCHF7 MDM2 MDM4 MEX3A MEX3C MGRN1 MIB1 MIB2 MID1 MID2 MKRN2 MKRN3 MUL1 MYCBP2 MYLIP NAT10 NBR1 NEDD4 NEDD4L NFKB1 NFKBIA NPR1 NSMCE1 OBI1 OTUB1 PDZRN3 PELI1 PHF7 PHRF1 PJA1 PJA2 PMAIP1 POLL POLM PRKN QSOX1 RAD18 RAF1 RAG1 RBCK1 RBX1 RC3H1 RC3H2 RCHY1 RELA RFFL RFWD3 RIGI RING1 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF123 RNF126 RNF13 RNF130 RNF135 RNF138 RNF14 RNF144A RNF146 RNF149 RNF150 RNF151 RNF166 RNF167 RNF168 RNF170 RNF181 RNF185 RNF186 RNF19A RNF19B RNF2 RNF20 RNF213 RNF216 RNF220 RNF224 RNF25 RNF26 RNF31 RNF34 RNF38 RNF4 RNF40 RNF43 RNF5 RNF7 RNF8 RSPRY1 RTF2 SIAH1 SIAH2 SMURF1 SMURF2 SNCA SOCS6 SPOP STAM2 STK11 STUB1 SYVN1 TOPORS TP53 TRAF2 TRAF6 TRAF7 TRAIP TRIM10 TRIM11 TRIM13 TRIM17 TRIM2 TRIM21 TRIM23 TRIM25 TRIM26 TRIM27 TRIM28 TRIM3 TRIM31 TRIM32 TRIM33 TRIM34 TRIM35 TRIM36 TRIM37 TRIM38 TRIM39 TRIM41 TRIM43 TRIM45 TRIM46 TRIM47 TRIM5 TRIM50 TRIM54 TRIM55 TRIM62 TRIM63 TRIM65 TRIM7 TRIM8 TRIP12 TTC3 UBA1 UBA3 UBA5 UBA6 UBASH3B UBD UBE3A UBE3C UBE4A UBE4B UBOX5 UBR1 UBR2 UBR3 UBR4 UBR5 UFM1 UHRF1 UHRF2 UVSSA VHL VPS11 VPS18 WSB1 WWP1 WWP2 XIAP ZNRF1 ZNRF2 ZNRF4	62 interacting genes: ABI2 ATXN1 BTG3 CFTR CLIP4 DERL1 ERGIC3 FADS6 GABARAP GABARAPL1 GABARAPL2 GEM GLIS2 GPR137B HSPA4 ICMT IQCB1 IRAK1 KCTD9 LCN2 MAP1LC3A MAP1LC3B MAP1LC3C MID2 MOB1A MYCN NDRG2 NTAQ1 PDE9A PELI2 PIAS3 PIAS4 PTCD2 PTPN11 RAB29 RABAC1 RNF208 RNF41 SCGB1A1 SDCBP SYT6 TCEANC TOP1 TRIM23 TRIM27 TRIM5 TRIM72 TTC23 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBE2V1 UBQLN1 UBQLN4 VPS11 XIAP
Entrez ID		7322	22954
HPRD ID		04268	03797
Ensembl ID		ENSG00000131508	ENSG00000119401
Uniprot IDs		P62837	Q13049
PDB IDs		1UR6 1W4U 2CLW 2ESK 2ESO 2ESP 2ESQ 3A33 3JVZ 3JW0 3L1Y 3TGD 3ZNI 4A49 4A4B 4A4C 4AUQ 4DDG 4DDI 4LDT 4V3K 4V3L 4WZ3 5D0K 5D0M 5D1K 5D1L 5D1M 5EDV 5MNJ 5ULF 5ULH 5ULK 5VZW 5ZBU 6HPR 6M2C 6SQO 6SQR 6SQS 6TTU 6W7Z 6W9D 7AI0 7AI1 7BOL 7R71 8B3I 8GBQ 8GCB 8GRM 8JWJ 8JWU 8V0D 8VK8 8VK9	2CT2 5FEY
GO Terms Enriched among Interactors		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Transferase Activity Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Zinc Ion Binding Macromolecule Catabolic Process Proteolysis Macromolecule Metabolic Process Metal Ion Binding Catabolic Process Protein Autoubiquitination Proteasomal Protein Catabolic Process Protein Catabolic Process Protein K48-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K63-linked Ubiquitination Ubiquitin Ligase Complex Cytoplasm Protein Monoubiquitination Response To Stress Regulation Of Signal Transduction Immune System Process Cellular Response To Stress Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Ubiquitin-ubiquitin Ligase Activity Positive Regulation Of Protein Ubiquitination Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of Catabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Post-translational Protein Modification Regulation Of Post-translational Protein Modification Negative Regulation Of Signaling Negative Regulation Of Cell Communication Ubiquitin Binding Positive Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Canonical NF-kappaB Signal Transduction Defense Response To Symbiont	Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Ubiquitination Cellular Response To Nitrogen Starvation Protein Polyubiquitination Protein Modification Process Phosphatidylethanolamine Binding Ubiquitin-protein Transferase Activity Autophagosome Ubiquitin Protein Ligase Activity Autophagy Protein Metabolic Process Autophagosome Maturation Positive Regulation Of Post-translational Protein Modification Mitophagy Positive Regulation Of Protein Polyubiquitination Protein K63-linked Ubiquitination Autophagy Of Mitochondrion Ubiquitin Protein Ligase Binding Autophagosome Membrane Cellular Response To Nutrient Levels Regulation Of Protein Polyubiquitination Autophagosome Assembly Protein-containing Complex Disassembly Response To Stress Cellular Response To Stress Autophagosome Organization Catabolic Process Positive Regulation Of Protein Ubiquitination Macroautophagy Vacuole Organization Regulation Of Post-translational Protein Modification Protein Binding Macromolecule Metabolic Process Cytoplasmic Vesicle Positive Regulation Of Protein Modification Process Modification-dependent Protein Catabolic Process Protein Monoubiquitination Proteolysis Involved In Protein Catabolic Process Protein K48-linked Ubiquitination Phospholipid Binding Transferase Activity Regulation Of Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Actin Nucleation Positive Regulation Of Protein Metabolic Process Response To Nutrient Levels Regulation Of Macromolecule Metabolic Process Organelle Membrane