NR2C2 and JAZF1

Number of citations: 39 (PubMedID 15302918)
Data Source: HPRD (two hybrid, in vitro, in vivo)

		NR2C2	JAZF1
Name		nuclear receptor subfamily 2 group C member 2	JAZF zinc finger 1
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Fibrillar Center Nucleus Nucleoplasm Cytosol Transcription Repressor Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Spermatogenesis Nervous System Development Cell Differentiation Intracellular Receptor Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Embryonic Development Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade	Negative Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process
Pathways		Nuclear Receptor transcription pathway	None
Diseases		None	Type II diabetes mellitus
GWAS		Alcohol and nicotine co-dependence ( 22488850 ) Femur bone mineral density x serum urate levels interaction ( 34046847 )	A body shape index ( 34021172 ) Alanine aminotransferase levels ( 33339817 33547301 ) Alanine transaminase levels ( 29403010 ) Alcoholic chronic pancreatitis ( 28754779 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Allergic rhinitis ( 30013184 ) Appendicular lean mass ( 33097823 ) Asthma ( 31959851 31619474 30929738 32296059 34103634 31361310 ) Asthma (adult onset) ( 30929738 ) Asthma (childhood onset) ( 30929738 31036433 ) Asthma onset (childhood vs adult) ( 30929738 ) Blond vs. brown/black hair color ( 30531825 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Body mass index and type 2 diabetes (pairwise) ( 33619380 ) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 23128233 ) Eosinophilic esophagitis ( 29904099 ) Fasting glucose ( 34059833 ) FEV1 ( 30804560 ) Free thyroxine concentration ( 24722205 ) Gout ( 22179738 ) Heel bone mineral density ( 28869591 30598549 ) Height ( 28552196 18952825 19343178 20881960 23563607 25282103 ) Hip circumference adjusted for BMI ( 34021172 25673412 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Lung function (FVC) ( 30804560 ) Lymphocyte count ( 32888494 27863252 ) Lymphocyte percentage of white cells ( 32888494 27863252 ) Medication use (drugs used in diabetes) ( 31015401 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) Moyamoya disease ( 29273593 ) Multiple sclerosis ( 31604244 24076602 ) Neutrophil percentage of white cells ( 32888494 ) Peak expiratory flow ( 30804560 ) Prostate cancer ( 34012061 31562322 18264096 ) Prostate-specific antigen levels ( 28139693 ) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417 ) Rheumatoid arthritis ( 30423114 24390342 ) Systemic lupus erythematosus ( 26606652 28714469 19838195 26502338 ) Systemic lupus erythematosus and Systemic sclerosis ( 23740937 ) Systolic blood pressure ( 30224653 30578418 ) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010 ) Total body bone mineral density ( 29304378 ) Triglyceride levels ( 32203549 ) Type 1 diabetes ( 34127860 ) Type 2 diabetes ( 32499647 30054458 18372903 30297969 29358691 28869590 20581827 22885922 24509480 26961502 31118516 27189021 ) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 25673412 34021172 28448500 28552196 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Youthful appearance (self-reported) ( 32339537 )
Interacting Genes		23 interacting genes: AR CD2AP CDC37 CHUK ESR1 FKBP5 HDAC4 HNF4A HSP90AA1 HSP90AB1 IKBKB ITSN2 JAZF1 KDM1A NR2C1 NR2C2AP PEBP1 RAC1 RXRB TAB1 TAB2 TRAF2 TRIM55	4 interacting genes: FAM9B NR2C2 PPARG RXRA
Entrez ID		7182	221895
HPRD ID		03253	09373
Ensembl ID		ENSG00000177463	ENSG00000153814
Uniprot IDs		F2YGU2 P49116	Q86VZ6
PDB IDs		3P0U 7XV6 7XV8 7XV9 7XVA	Not available
GO Terms Enriched among Interactors		Regulation Of Signal Transduction Non-canonical NF-kappaB Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Intracellular Signal Transduction Nuclear Receptor Activity Regulation Of Signaling Canonical NF-kappaB Signal Transduction Intracellular Receptor Signaling Pathway Nuclear Steroid Receptor Activity Intracellular Signaling Cassette Nitric-oxide Synthase Regulator Activity CD40 Receptor Complex Positive Regulation Of Intracellular Signal Transduction Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Protein Modification Process HSP90-CDC37 Chaperone Complex Regulation Of Nitric Oxide Metabolic Process Protein Kinase Binding Scaffold Protein Binding Positive Regulation Of Signal Transduction Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway IkappaB Kinase Activity Rho GDP-dissociation Inhibitor Binding Protein-containing Complex Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nuclear Receptor-mediated Signaling Pathway Protein Folding Chaperone Complex Cytosol Enzyme Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Nitric Oxide Biosynthetic Process Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Metabolic Process Cytoplasm Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Innate Immune Response Telomerase Holoenzyme Complex Assembly Regulation Of Immune Response Histone Deacetylase Binding Nucleoplasm Response To External Biotic Stimulus IkappaB Kinase Complex Hormone-mediated Signaling Pathway Dendritic Growth Cone TPR Domain Binding	Nuclear Receptor Activity DNA Binding Domain Binding Positive Regulation Of Lipoprotein Transport LBD Domain Binding Peroxisome Proliferator Activated Receptor Signaling Pathway Monocyte Differentiation Intracellular Receptor Signaling Pathway Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Cholesterol Efflux Cellular Response To Low-density Lipoprotein Particle Stimulus Peptide Binding Positive Regulation Of Cholesterol Transport Cellular Response To Lipoprotein Particle Stimulus Transcription Coregulator Binding Regulation Of Cholesterol Efflux MRNA Transcription By RNA Polymerase II Sequence-specific DNA Binding MRNA Transcription Regulation Of Cholesterol Transport Positive Regulation Of Lipid Transport Nuclear Receptor-mediated Signaling Pathway DNA-binding Transcription Factor Activity Double-stranded DNA Binding RNA Polymerase II Transcription Regulator Complex Regulation Of Lipid Transport Positive Regulation Of Lipid Metabolic Process Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Myeloid Leukocyte Differentiation Cell Maturation Hormone-mediated Signaling Pathway Positive Regulation Of Adiponectin Secretion Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Vitamin D Response Element Binding Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Receptor Complex Cellular Developmental Process Developmental Maturation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Prostaglandin Receptor Activity Negative Regulation Of Mitochondrial Fission Positive Regulation Of Protein Transport Myeloid Cell Differentiation Arachidonate Binding Transcription Cis-regulatory Region Binding Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process