TPT1 and MLC1

Number of citations: 0 (PubMedID 12149273)
Data Source: HPRD (two hybrid, in vitro, in vivo)

		TPT1	MLC1
Name		tumor protein, translationally-controlled 1	modulator of VRAC current 1
Structure			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Extracellular Space Nucleus Nucleoplasm Cytoplasm Multivesicular Body Cytosol Cytoplasmic Microtubule Extracellular Exosome	Cytoplasm Lysosome Endosome Early Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Caveola Cell-cell Junction Membrane Basolateral Plasma Membrane Apical Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Raft Perinuclear Region Of Cytoplasm Recycling Endosome Astrocyte End-foot
	Molecular Function	RNA Binding Calcium Ion Binding Protein Binding DNA-binding Transcription Factor Binding	Protein Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Calcium Ion Transport Intracellular Calcium Ion Homeostasis Response To Virus Stem Cell Population Maintenance Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Ectoderm Development	Protein Transport Vesicle-mediated Transport Positive Regulation Of Intracellular Transport Regulation Of Response To Osmotic Stress Cellular Response To Cholesterol Caveolin-mediated Endocytosis
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	None
Diseases		None	Megalencephalic leukoencephalopathy with subcortical cysts (MLC)
GWAS		Type 2 diabetes ( 25760438 )	Acne (severe) ( 24927181 ) Body mass index (adult) ( 28430825 ) Femur bone mineral density x serum urate levels interaction ( 34046847 )
Novel Interactors		None recorded	2 novel interactors: IRF8 NAT14
Interacting Genes		30 interacting genes: APP ATP1A1 ATP1A2 BCL2L1 CALM1 CEBPA DBN1 EEF1A1 EEF1B2 EEF1D FANCA HSPB1 IKBKG LIG4 MCL1 MCPH1 MDM2 MLC1 NKX3-1 NOTCH3 PER2 PLK1 RBBP6 SNX6 SPP1 STEAP3 TRIP13 TUBB2A USP40 VHL	7 interacting genes: DAPK2 KDM1A MYLK PRMT6 ROCK1 SNCA TPT1
Entrez ID		7178	23209
HPRD ID		15979	05800
Ensembl ID		ENSG00000133112	ENSG00000100427
Uniprot IDs		A0A0B4J2C3 P13693	B7Z2T9 Q15049
PDB IDs		1YZ1 2HR9 3EBM 4Z9V 5O9L 5O9M 6IZB 6IZE	Not available
GO Terms Enriched among Interactors		Eukaryotic Translation Elongation Factor 1 Complex Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Stress Response To Stress DNA Damage Response Response To Steroid Hormone Regulation Of Autophagy Intracellular Signal Transduction Regulation Of Blood Circulation Regulation Of System Process Regulation Of Apoptotic Signaling Pathway Translation Elongation Factor Activity Regulation Of Neurotransmitter Uptake Cell Communication By Electrical Coupling Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Negative Regulation Of Blood Circulation Response To Radiation Negative Regulation Of Apoptotic Process Nucleus Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Amyloid Fibril Formation Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Response To Metal Ion Identical Protein Binding Regulation Of Programmed Cell Death Protein Heterodimerization Activity Positive Regulation Of Proteolysis Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Response To Cytokine Negative Regulation Of RNA Biosynthetic Process Regulation Of Biological Quality Negative Regulation Of DNA-templated Transcription Response To Peptide Regulation Of Transport Steroid Hormone Binding P-type Potassium Transmembrane Transporter Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway BH3 Domain Binding Negative Regulation Of Apoptotic Signaling Pathway P-type Sodium:potassium-exchanging Transporter Activity Response To Glycoside Regulation Of Neuron Apoptotic Process Cytosol Sodium Ion Binding	Regulation Of Synaptic Vesicle Recycling Bleb Assembly Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Synaptic Vesicle Endocytosis Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Transcription By RNA Polymerase II Plasmacytoid Dendritic Cell Differentiation Smooth Muscle Contraction Phosphorylation Protein Phosphorylation Protein Serine/threonine Kinase Activity Myosin Light Chain Kinase Activity Transferase Activity Regulation Of Endocytosis Rho-dependent Protein Serine/threonine Kinase Activity Regulation Of Amide Metabolic Process Negative Regulation Of Apoptotic Process Tau Protein Binding Negative Regulation Of Catabolic Process Epithelial To Mesenchymal Transition Regulation Of Autophagy Negative Regulation Of Programmed Cell Death Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Norepinephrine Uptake Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Ectoderm Development Regulation Of Apoptotic Signaling Pathway Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Positive Regulation Of Eosinophil Chemotaxis Positive Regulation Of Eosinophil Migration Autophagosome Lumen Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Response To Type II Interferon Positive Regulation Of Calcium Ion Transport Regulation Of Locomotion Neuron Apoptotic Process Regulation Of Signal Transduction Mesenchymal Cell Differentiation Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy